Zaph, Colby - Monash University - Department of Biochemistry and Molecular Biology

研究领域

The overarching goal of research in the Zaph lab is to define the cellular and molecular mechanisms that control immunity and inflammation at mucosal sites such as the intestine and the lung. The various subsets of immune and non-immune cells at mucosal sites are present in a tightly controlled equilibrium that when perturbed by infection, chemicals or genetic predisposition, results in dysregulated inflammation and diseases including asthma and allergy, inflammatory bowel diseases (IBDs), food allergies and cancer. Understanding the molecular and cellular principles underlying mucosal inflammation represents a potential target for identifying novel therapeutics for the treatment of these diseases

近期论文

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Bergstrom K.S., Morampudi V., Chan J.M., Bhinder G., Lau J., Yang H., Ma C., Huang T., Ryz N., Sham H.P., Zarepour M., Zaph C., Artis D., Nair M. and Vallance B.A. 2015. Goblet Cell Derived RELM-β Recruits CD4+ T Cells during Infectious Colitis to Promote Protective Intestinal Epithelial Cell Proliferation. PLoS Pathog. 11(8):e1005108. Gold, M.J., Hughes, M.R., Antignano, F., Hirota, J.A., Zaph, C. and McNagny, K.M. 2015. Lineage-specific regulation of allergic airway inflammation by the lipid phosphatase SHIP-1. J. Allergy Clin. Immunol. 136(3):725-736. Antignano, F. and Zaph, C. 2015. Regulation of CD4 T-cell differentiation and inflammation by repressive histone methylation. Immunol. Cell Biol. 93(3):245-52. Zaph, C., Cooper, P.J. and Harris, N.L. 2014. Mucosal immune responses following intestinal nematode infection. Parasite Immunol. 36 (9): 439-452. Barsyte-Lovejoy, D.*, Li, F.*, Oudhoff, M.J.*, Tatlock, J.H.*, Dong, A., Zeng, H., Wu, H., Freeman, S.A., Schapira, M., Senisterra, G.A., Kuznetsova, E., Marcellus, R., Allali-Hassani, A., Kennedy, S., Lambert, J.-P., Couzens, A.L., Aman, A., Gingras, A.-C., Al-Awar, R., Fish, P.V., Gerstenberger, B.S., Roberts, L., Benn, C.L., Grimley, R.L., Braam, M.J.S., Rossi, F.M.V., Sudol, M., Brown, P.J., Bunnage, M.E., Owen, D.R., Zaph, C., Vedadi, M. and Arrowsmith, C.H. 2014. (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc. Natl. Acad. Sci U.S.A. 111 (35): 12853-12858. Antignano, F., Burrows, K., Hughes, M.L., Han, J.M., Kron, K.J., Penrod, N.M., Oudhoff, M.J., Wang, S.K.H., Min, P.H., Gold, M.J., Chenery, A., Braam, M.J.S., Fung, T.C., Rossi, F.M.V., McNagny, K.M., Arrowsmith, C.H., Lupien, M., Levings, M.K. and Zaph, C. 2014. Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation. J. Clin. Invest. 124 (5):1945-1955. Gold, M.J., Antignano, F., Halim, T.Y.F., Blanchet, M.-R., Zaph, C., Takei, F. and McNagny, K.M. 2014. Group 2 Innate Lymphoid Cells Facilitate Sensitization to Local but not Systemic Th2-Inducing Allergen Exposures. J. Allergy Clin. Immunol. 133 (4):1142-1148. Mullaly, S.C., Oudhoff, M.J., Min, P.H., Burrows, K., Antignano, F. Rattray, D.G., Chenery, A., McNagny, K.M., Ziltener, H.J. and Zaph, C. 2013. Requirement for Core 2 O-Glycans for Optimal Resistance to Helminth Infection. PLoS ONE 8 (3): e60124. Oudhoff, M.J., Freeman, S.A., Couzens, A.L., Antignano, F., Min, P.H., Northrop, J.P., Burrows, K., Chenery, A., Lehnertz, B., Barsyte-Lovejoy, D., Vedadi, M, Arrowsmith, C.H., Nishina, H., Gold, M.R., Rossi, F.M.V., Gingras, A.-C. and Zaph, C. 2013. Regulation of the Hippo pathway through Set7-dependent methylation of Yap. Dev. Cell. 26 (2): 188-194. Chenery, A., Burrows, K., Antignano, F. Underhill, T.M., Petkovich, M. and Zaph, C. 2013. The retinoic acid-metabolizing enzyme Cyp26b1 regulates CD4 T cell differentiation and function. PLoS ONE 8 (8): e72308.