Wilce, Matthew - Monash University - Department of Biochemistry and Molecular Biology

研究领域

Our research is concerned with undstanding molecular mechanisms in a number of key areas including: Control of gene expression at the level of mRNA microbial systems, antibiotic resistance and the development of new antibiotics Cancer Progression Innate Immunity Fluorescent Proteins

近期论文

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Structural Basis of Selective Aromatic Pollutant Sensing by the Effector Binding Domain of MopR, an NtrC Family Transcriptional Regulator. Ray S, Gunzburg MJ, Wilce M, Panjikar S, Anand R. ACS Chem Biol. 2016 Aug 19;11(8):2357-65. doi: 10.1021/acschembio.6b00020. Epub 2016 Jun 30. Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7. Gunzburg MJ, Kulkarni K, Watson GM, Ambaye ND, Del Borgo MP, Brandt R, Pero SC, Perlmutter P, Wilce MC, Wilce JA. Sci Rep. 2016 Jun 3;6:27060. doi: 10.1038/srep27060. Through a Culturally Competent Lens: Why the Program Evaluation Standards Matter. Gill S, Kuwahara R, Wilce M. Health Promot Pract. 2016 Jan;17(1):5-8. doi: 10.1177/1524839915616364. Cyclic Peptides Incorporating Phosphotyrosine Mimetics as Potent and Specific Inhibitors of the Grb7 Breast Cancer Target. Watson GM, Gunzburg MJ, Ambaye ND, Lucas WA, Traore DA, Kulkarni K, Cergol KM, Payne RJ, Panjikar S, Pero SC, Perlmutter P, Wilce MC, Wilce JA. J Med Chem. 2015 Oct 8;58(19):7707-18. doi: 10.1021/acs.jmedchem.5b00609. Epub 2015 Sep 23. Conserved features in TamA enable interaction with TamB to drive the activity of the translocation and assembly module. Selkrig J, Belousoff MJ, Headey SJ, Heinz E, Shiota T, Shen HH, Beckham SA, Bamert RS, Phan MD, Schembri MA, Wilce MC, Scanlon MJ, Strugnell RA, Lithgow T. Sci Rep. 2015 Aug 5;5:12905. doi: 10.1038/srep12905.