Tiganis, Tony - Monash University - Department of Biochemistry and Molecular Biology

研究领域

His general research interest is in understanding cellular signaling networks in human disease, with a specific focus on the roles of protein tyrosine phosphatases in metabolism, adaptive immunity and cancer

近期论文

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van Vliet, C., Bukczynska, P.E., Puryer, M.A., Sadek, C.M., Shields, B., Tremblay, M.L., and Tiganis, T. (2005) Selective regulation of TNF-induced ERK signalling by Src family kinases and the T-cell protein tyrosine phosphatase. Nature Immunology 6, 253-260. (2005 IF = 28.1) Lu, X., Malumbres, R., Shields, B., Natkunam, Y., Sarosiek, K.A., Jiang, X., Tiganis, T.,* and Lossos, I.S.* (2008) PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling. Blood 112, 4098-108. (2007 IF 10.9) * co-corresponding authors Beddoe. T., Chen, Z., Clements C.S., Ely, L.K., Bushell, S.R., Vivian, J.P., Kjer-Nielsen, L., Pang, S.S., Dunstone, M.A., Liu, Y.C., Macdonald, W.A., Perugini, M.A., Wilce, M.C.J., Burrows, S.R., Purcell, A.W., Tiganis, T., Bottomley, S.P., McCluskey, J., & Rossjohn, J. (2009) Antigen ligation triggers a conformational change within the constant domain of the αβ T-cell receptor. Immunity 30, 1–12. (2008 IF 20.58) Pang, S.S., Berry, R., Chen, Z., Kjer-Nielsen, L., Perugini, M.A., King, G.F., Wang, C., Chew, S.H., La Gruta, N.L., Williams, N.K., Beddoe, T., Tiganis, T., Cowieson, N.P., Godfrey, D.I., Purcell, A.W., Wilce, M.C.J., McCluskey, J. & J. Rossjohn (2010) The structural basis for autonomous dimerization of the pre-T-cell antigen receptor. Nature 467, 844-8. (2008 IF = 34.48) Wiede, F., Shields, B.J., Chew, S.H., Kyparissoudis, K., van Vliet, C., Galic, S., Tremblay, M.L., Russell, S.M., Godfrey, D.I., & T., Tiganis. (2011) T cell protein tyrosine phosphatase attenuates T cell signaling for the maintenance of tolerance in mice. The Journal of Clinical Investigation 121, 4758-74. (2010 IF 14.2) This manuscript was featured in a review/commentary in the same issue of J Clin Invest. [Zikherman J. & A. Weiss (2011) Unraveling the functional implications of GWAS: how T cell protein tyrosine phosphatase drives autoimmune disease. J. Clin. Invest. 121, 4618-4621] Wiede F. La Gruta, N., Tiganis, T. (2014) Ptpn2 attenuates T cell lymphopenia-induced proliferation. Nature Communications 5, 3073. (2014 IF 11.47) Wiede, F., Ziegler, A., Zehn, D., Tiganis, T. (2014) PTPN2 restrains CD8+ T cell responses after antigen cross-presentation for the maintenance of peripheral tolerance. Journal of Autoimmunity 53, 105-14. (2014 IF 8.41) Beringer D.X.#, Kleijwegt#, F.S., Wiede#, F., van der Slik, A.R., Loh, K.L., Petersen, J., Dudek, N.L., Duinkerken, G., Laban, S., Joosten, A., Vivian, J.P., Chen, Z., Uldrich, A.P., Godfrey, D.I., McCluskey, J., Price, D.A., Radford, K.J., Purcell, A.W., Nikolic, T., Reid, H.H.*, Tiganis, T.*, Roep, B.O.*, & Rossjohn, J.* (2015) T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex. Nature Immunology In press. (2014 IF 20.00)