Smith, Ian - Monash University - Department of Biochemistry and Molecular Biology

研究领域

Central and peripheral peptide regulators of cardiovascular function Endothelial cell peptidases involved in regulating cerebrovascular function. Peptidases involved in the biosynthesis and metabolism of neuropeptides. Design, synthesis and functional analysis of specific metalloendopeptidase inhibitors. Biomedical and Translational Proteomics

近期论文

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Chandana B H, Warner F J, Lubel J S, Dean R G, Zhiyuan J, Lew R A, Smith A I, Burrell L M, Angus P W. Upregulation of hepatic angiotensin-converting enzyme 2 (ACE2) and angiotensin-(1-7) levels in experimental biliary fibrosis. J Hepatol. 2007 Sep;47(3):387-95. Epub 2007 Apr 2. 1Rosado CJ, Buckle AM, Law RH, Butcher RE, Kan WT, Bird CH, Ung K, Browne KA, Baran K, Bashtannyk-Puhalovich TA, Faux NG, Wong W, Porter CJ, Pike RN, Ellisdon AM, Pearce MC, Bottomley SP, Emsley J, Smith AI, Rossjohn J, Hartland EL, Voskoboinik I, Trapani JA, Bird PI, Dunstone MA, Whisstock JC. A common fold mediates vertebrate defense and bacterial attack. Science. 2007 Sep 14;317(5844):1548-51. Epub 2007 Aug 23 1M.-I. Aguilar, A.W. Purcell, R. Devi, R. Lew, J. Rossjohn, A.I. Smith and P. Perlmutter (2007) " Beta-Amino acid-containing hybrid peptides - new opportunities in peptidomimetics", Org Biomol Chem. 2007 Sep 21;5(18):2884-90. Epub 2007 Aug 3 Kuruppu S, Reeve S, Smith A I. Characterisation of endothelin converting enzyme-1 shedding from endothelial cells. FEBS Letters, 2007 Volume 581, Issue 23, Pages 4501-4506 Jokubaitis V J Sinka S, Driessen R, Whitty G , Haylock D N, Bertoncello I, Smith A I, Péault B, Tavian M and Simmons P J. Angiotensin-converting enzyme (CD143) marks hematopoietic stem cells in human embryonic, fetal and adult hematopoietic tissues. Blood 2008 Apr 15;111(8):4055-6 R A. Lew, FJ. Warner, I Hanchapola, M A. Yarski, J. Manohar, L M. Burrell, A. I Smith. ACE2 catalytic activity in plasma is masked by an endogenous inhibitor. Experimental Physiology 2008 May;93(5):685-93 L Burchill, E Velkoska, R G Dean, R A Lew, A. I Smith, V Levidiotis, and L Burrell. Acute kidney injury in the rat causes cardiac remodelling and increases ACE2 expression. Experimental Physiology 93 5 2008) Lai Z-W, Hanchapola I & Smith A I, Quenched fluorescent peptide substrates: tools for the discovery of novel biomarkers. Chemistry Today 2008 vol 26 n 2 / March-April 2008 29-31 Lai, R A. Lew, M A. Yarski, F-T Mu, R K. Andrews and A. I Smith. The identification of a calmodulin-binding domain within the cytoplasmic tail of angiotensin-converting enzyme-2.Endocrinology 2009 May;150(5):2376-81 Velkoska E, Warner FJ, Cole TJ, Smith AI, Morris MJ. Metabolic effects of low dose angiotensin converting enzyme inhibitor in dietary obesity in the rat. Nutrition, Metabolism & Cardiovascular Diseases 2009 Apr 8. [Epub ahead of print] Clayton D, Hanchapola I, Perlmutter P, Smith AI, Aguilar MI. The active site specificity of angiotensin II converting enzyme 2 investigated through single and multiple residue changes and beta-amino acid substrate analogs. Adv Exp Med Biol. 2009;611:559-60 Smith AI, Warner FJ, Lew RA, Yarski M, McGrath B, Burrell LM. Quenched fluorescent peptide substrates as tools for the discovery of novel cardiovascular disease biomarkers. Adv Exp Med Biol. 2009;611:419-22