Sleeman, Mark - Monash University - Department of Biochemistry and Molecular Biology

研究领域

For the past two decades he has been interested in the interplay between insulin resistance and obesity, and more specifically the molecular mechanisms behind the regulation food intake and body weight. To that end he and his colleagues have generated a large number of genetically modified animals to study these phenotypes. Recently, his research has focused on modulators of lipid metabolism and the development of fully human monoclonal antibody therapeutics for the potential treatment of metabolic disease.

近期论文

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Lambert, P.D., Anderson, K.D., Sleeman M.W. J. Tan, A. Hijarunguru, A., Corcoran T.L., Murray, J.D., Thabet, K.E., Yancopoulos, G.D. & Wiegand, S.J. Ciliary Neurotrophic Factor Activates Leptin-like Pathways and Reduces Body Fat, without Cachexia or Rebound Weight Gain, even in Leptin-resistance Obesity. PNAS, USA 98(8) 4657, 2001. M.W. Sleeman, K. K. Garcia, R. Liu, J.D. Murray, L. Malinova, M. Moncrieffe, G.D. Yancopoulos & S.J. Wiegand. Ciliary Neurotrophic Factor Improves Type 2 Diabetes, Hepatic Steatosis, with Profound Effects on Metabolic Rate, in db/db mice. PNAS, USA 100(24) 14297, 2003. Wortley K.E, Anderson, K.D., Garcia K., Murray, JD., Malinova, L., Liu, R., Moncrieffe, M., Thabet, K., Cox, H.J., Yancopoulos, G.D., Wiegand S.J. & Sleeman, M.W. Genetic Deletion of Ghrelin Does Not Decrease Food Intake, but Influences Metabolic Fuel Preference. PNAS, USA 1001 (21) 8227, 2004. Blüher, S. Stergios M., Bullen S.J., Kokkotou, E., Maratos-Flier, E., Wiegand, S.J., Sleeman, M.W. & Mantzoros, C.S. CNTFAx15alters energy homeostasis and decreases body weight in diet-induced obese and UCP1-DTA mice. Diabetes, 53 (11), 2004. Lynn E. Macdonald, Katherine E. Wortley, Lori C. Gowen, Keith D. Anderson, Jane Murray, William T. Poueymirou, Mary V. Simmons, Dianna Barber, David M. Valenzuela, Aris N. Economides, Stanley J. Wiegand, George D. Yancopoulos, Mark W. Sleeman, Andrew J. Murphy. Resistance to Diet-Induced Obesity in Mice Globally Over-expressing OGH/GPB5. PNAS, USA 102 (7) 2496, 2005. M.W. Sleeman, K-M. Lia, K.Wortley, L. Gowen, M.Gonzales, J.Kintner, K. Garcia, J. Murray, T. N. Stitt, S. J.Wiegand, G. D. Yancopoulos, & D. Glass. SHIP2 Deletion Confers Resistance to Diet Induced Obesity. Nature Medicine 11, 199-205, 2005. Katherine E. Wortley, Keith D. Anderson, Jane D. Murray, Karen Garcia, Rong Liu, Lubomira Malinova, George D. Yancopoulos, Stanley J. Wiegand and Mark W. Sleeman. Transient pharmacodynamic effects of Recombinant Human Variant CNTF on orexigenic neuronal function and rebound hyperphagia following drug withdrawal. Obesity & Metabolism. 1 (1), 31-38, 2005. Natasha L. Harvey, R. Sathish Srinivasan, Miriam E. Dillard,, Nicole C. Johnson, Kelli Boyd, Mark W. Sleeman and Guillermo Oliver. Lymphatic Vascular defects Results in Adult-Onset Obesity. Nature Genetics October 37(10); 1072-81, 2005. Katherine E. Wortley, Juan-Pablo del Rincon, Jane D. Murray, Karen Garcia, Keiji Iida, Michael O. Thorner & Mark W. Sleeman. Absence of ghrelin protects against early-onset obesity. J. Clin. Invest. 11: 3573-3578, 2005. Katherine E Wortley, Keith D. Anderson, Jason Yasenchak, Andrew Murphy, David Valenzuela, George D. Yancopoulos, Sabrina Diano, Stanley J. Wiegand and Mark W. Sleeman. Agouti-Related Protein-Deficient Mice Display An Age-Related Lean Phenotype. Cell Metabolism. 2: 421-427, 2005.