Purcell, Anthony - Monash University - Department of Biochemistry and Molecular Biology

研究领域

Next Generation Proteomics: We are developing novel targeted approaches for the analysis of complex samples which include precursor scanning approaches, multiple reaction monitoring, data independent acquisition techniques such as SWATH MS. Studies of the immunopeptidome in health and disease: The major focus of my lab is studying the peptides liberated from pathogens, self proteins, tumor proteins that are presented on the cell surface for scrutiny by T lymphocytes. The following areas are under active investigation

近期论文

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W Chen, NJ Ede, J McCluskey, DC Jackson, AW Purcell (1996) CTL recognition of an altered peptide associated with asparagine bond rearrangement. J Immunol, 157:1000-5 AW Purcell, W Chen, N Ede, J Gorman, J Fecondo, D Jackson, Y Zhao, J McCluskey (1998) Avoidance of self-reactivity results in skewed CTL responses to rare components of synthetic immunogens. J Immunol, 160:1085-90 MJ Barnden*, AW Purcell* (joint first authors), JJ Gorman, J McCluskey (2000) Tapasin-mediated retention and optimization of peptide ligands during Class I assembly. J Immunol, 165: 322-330 AP Williams, CA Peh, AW Purcell, J McCluskey, T Elliott (2002) Optimisation of the MHC Class I peptide cargo is catalysed by Tapasin. Immunity, 16: 509-520 WA Macdonald*, AW Purcell*, N Mifsud, L Ely, D Williams, L Chang, J Gorman, C Clements, L Kjer-Nielsen, D Koelle, AG Brooks, GO Lovrecz, L Lu, J Rossjohn, J McCluskey (2003) A naturally selected dimorphism within the HLA-B44 supertype alters Class I structure, peptide repertoire and T cell recognition. J Exp Med, 198: 679-691 (*joint first authors) D Zernich*, AW Purcell*, WA Macdonald, L Kjer-Nielsen, LK Ely, N Laham, TL Crockford, NA Mifsud, M Bharadwaj, L Chang, BD Tait, R Holdsworth, AG Brooks, SP Bottomley, T Beddoe, CA Peh, J Rossjohn, J McCluskey (2004) Natural HLA Class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion. J Exp Med, 200:13-24 (*equal contributors) AW Purcell, JJ Gorman (2004) Immunoproteomics: Mass spectrometry based methods to study the specificity of immune responses. Mol Cell Proteomics, 3:193-208 NA Borg, LK Ely, T Beddoe, WA Macdonald, HH Reid, CS Clements, AW Purcell, L Kjer-Nielsen, JJ Miles, SR Burrows, J McCluskey, J Rossjohn (2005) The CDR3 hypervariable regions of an immunodominant alpha-beta T Cell Receptor dictate the energetic landscape of cognate MHCp recognition. Nature Immunol, 6:171-180 SJ Turner, K Kedzierska, H Komodromou, NL La Gruta, MA Dunstone, AI Webb, R Webby, H Walden, W Xie, J McCluskey, AW Purcell, J Rossjohn, PC Doherty (2005) Lack of prominent peptide/MHC features limits T cell repertoire diversity for virus-specific CD8+ T cells. Nature Immunol, 6: 382-389 FE Tynan, AM Buckle, SR Burrows, CS Clements, NA Borg, JJ Miles, T Beddoe, JC Whisstock, MC Wilce, SL Silins, JM Burrows, L Kjer-Nielsen, L Kostenko, AW Purcell, J McCluskey, J Rossjohn (2005) TCR recognition of a super-bulged MHC-I viral epitope maintains MHC-restriction. Nature Immunol, 6: 1114-22