Jans, David - Monash University - Department of Biochemistry and Molecular Biology

研究领域

His research endeavour encompasses analysis of (a) mammalian signal transduction from membrane to nucleus, (b) signalling at the cell membrane using biophysical imaging techniques, (c) the regulation by phosphorylation of transport into and out of the nucleus, using quantitative microscopic analysis, (d) nucleocytoplasmic transport kinetics in dynamic living cell systems using single cell confocal microscopic measurements, and the importance thereof in the function of proteins regulating cancer and development (d) the molecular basis of sex determination through impaired nuclear import, (e) microtubule-dependent "fast track" nuclear transport of cancer regulatory and viral proteins, and (f) nuclear import of specific viral proteins and its critical importance to infection by the lethal human viral pathogens Dengue, HIV, Rabies, and Respiratory Syncytial Virus.

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Jans, D.A., Peters, R., Zsigo, J. & Fahrenholz, F. (1989) "The adenylate cyclase-coupled vasopressin V2-receptor is highly laterally mobile in membranes of LLC-PK1 renal epithelial cells at physiological temperature" EMBO J. 8, 2481-2488 Jans, D.A., Peters, R. & Fahrenholz, F. (1990) "Lateral mobility of the phospholipase-C-activating vasopressin V1-type receptor in A7r5 smooth muscle cells: a comparison with the adenylate cyclase-coupled V2-receptor" EMBO J. 9, 2693-2699 Jans, D.A., Peters, R., Jans, P. & Fahrenholz, F. (1991) "Vasopressin V2-receptor mobile fraction and ligand-dependent adenylate cyclase-activity are directly correlated in LLC-PK1 renal epithelial cells" J. Cell Biol. 114, 53-60 Jans, D. A. (1992) "The mobile receptor hypothesis revisited: a mechanistic role for hormone receptor lateral mobility in signal transduction" Biochim. Biophys. Acta 1113, 271-276 Jans, D.A. The mobile receptor hypothesis: the role of membrane receptor lateral movement in signal transduction. R.G. Landes Bioscience Publishers, Austin, Texas. 1997. 224 pages. (Monograph) Jans, D.A., Ackermann, M., Bischoff, J.R., Beach, D.H. & Peters, R. (1991) "p34cdc2-mediated phosphorylation at T124 inhibits nuclear import of SV40 T-antigen proteins" J. Cell Biol. 115, 1203-1212 Citations 187 Rihs, H-P., Jans, D.A., Fan, H. & Peters, R. (1991) "The rate of nuclear cytoplasmic protein transport is determined by a casein kinase II site flanking the nuclear localization sequence of the SV40 T-antigen" EMBO J. 10, 633-639 Citations 338 Jans, D.A. & Jans, P. (1994) "Negative charge at Ser112 of the casein kinase II site flanking the nuclear localization signal of the SV40 large T-antigen is mechanistically important in enhancing nuclear import" Oncogene 9, 2961-2968 Hübner, S., Xiao, C-Y. & Jans, D.A. (1997) "The protein kinase CK2 site (Ser111/112) enhances recognition of the SV40 large T-antigen nuclear localization sequence by importin" J. Biol. Chem. 272, 17191-17195 Citations 165 Lam, M.H.C., Briggs, L.J., Hu, W., Martin, T.J., Gillespie, M.T. & Jans, D.A. (1999) "Importin eta recognizes parathyroid hormone-related protein (PTHrP) with high affinity and mediates its nuclear import in the absence of importin lpha" J. Biol. Chem. 274, 7391-7398 Citations 137 Fulcher, A.F., Roth, D.M., Fatima, S., Alvisi, G. & Jans, D.A. (2010) "The BRCA-1 binding protein BRAP2 is a novel, negative regulator of nuclear import of viral proteins, dependent on phosphorylation flanking the nuclear localization signal" FASEB J. 24, 1454-1466