Devenish, Rod - Monash University - Department of Biochemistry and Molecular Biology

研究领域

All eukaryotic cells degrade (or turnover) parts of their internal structure including organelles by a process called autophagy ("self eating") that occurs in a specialized compartment of cells - the vacuole (in yeast) or the lysosome (in mammals). In yeast, autophagy is mainly involved in cellular homeostasis (removal of damaged organelles) and adaptation to starvation, but in multicellular organisms (mammals) it is involved in a variety of additional processes such as programmed cell death and development of different tissue-specific functions. Alterations in the levels of autophagy are linked to a growing number of pathological conditions including neurodegenerative diseases such Parkinson's, myopathies such as cardiomyopathic Danon's disease, some forms of cancer, and infection by pathogenic bacteria or viruses.

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Mijaljica, D., Prescott, M. and Devenish, R.J. Nibbling within the nucleus: turnover of nuclear contents. Cellular and Molecular Life Sciences, 64,581-588 (2007). Nowikovsky K., Reipert S., Devenish R.J. and Schweyen R.J. Mdm38 protein depletion causes loss of mitochondrial K+/H+ exchange activity, osmotic swelling and mitophagy. Cell Death and Differentiation, 14, 1647-1656 (2007). Rosado, C., Mijaljica, D., Hatzinisiriou, I., Prescott, M., and Devenish, R.J: Rosella - a fluorescent pH-biosensor for reporting vacuolar turnover of cytosol and organelles in yeast. Autophagy, 4, 205-213 (2008). Cullinane, M., Gong L., Li X, Lazar-Adler N., Tra, T., Wolvetang, E., Prescott, M., Boyce, J.D., Devenish, R.J. and Adler , B. Stimulation of autophagy suppresses the intracellular survival of Burkholderia pseudomallei in mammalian cell lines. Autophagy. 4, 744-753 (2008). Devenish, R.J., Prescott, M., Turcic, K. and Mijaljica, D. Monitoring organelle turnover in yeast using fluorescent protein tags. Methods in Enzymology, 451, 109-131 (2008) Gong, L., Cullinane, M., Treerat, J., Ramm, G., Prescott, M., Adler, B., Boyce, J.D. and Devenish, R.J. Recruitment of LC3 to Burkholderia pseudomallei-containing phagosomes stimulates bacterial killing but bacteria that escape the phagosome are highly resistant to uptake by autophagosomes. PLoS ONE, 6(3): e17852 (2011). Mijaljica, D., Prescott, M. and Devenish, R.J. Microautophagy in mammalian cells: revisiting a forty year old conundrum. Autophagy 7: 673-682 (2011). Mijaljica, D., Prescott, M. and Devenish, R.J. A Fluorescence Microscopy Assay for Monitoring Mitophagy in the Yeast Saccharomyces cerevisiae. Journal of Visualised Experiments (2011) Jul 18;(53). pii: 2779. (http://www.jove.com/details.php?id=2779) D'Cruze, T., Gong, L., Treerat, P., Ramm, G., Boyce, J.D., Prescott, M., Adler, B. and Devenish, R.J. A role for the Burkholderia pseudomallei Type Three Secretion System cluster 1 bpscN gene in virulence. Infection and Immunity 79: 3659-3664 (2011). Mijaljica, M., Rosado, C.J., Devenish, R.J. and Prescott, M. Biosensors for Monitoring Autophagy, Biosensors - Emerging Materials and Applications, Pier Andrea Serra (Ed.), ISBN: 978-953-307-328-6, InTech, Available online from July 25 (2011): http://www.intechopen.com/articles/show/title/biosensors-for-monitoring-autophagy. Allwood, E.M., Devenish, R.J., Prescott, M., Adler, B. and Boyce, J.D. Strategies for intracellular survival of Burkholderia pseudomallei. Frontiers in Microbiology 2:170. doi: 10.3389/fmicb.2011.00170 Devenish RJ. Autophagy and the evasion of host defense: a new variation on the theme for Burkholderia cepacia? Autophagy, 7(11), 1269-1270 (2011). Editorial. Tra, T., Gong, L., Kao, L-P., Li, X-L., Grandela, C., Devenish, R.J., Wolvetang, E. and Prescott, M. Autophagy in human embryonic stem cells. PLoS ONE 6: e27485 (2011).