Aguilar, Mibel - Monash University - Department of Biochemistry and Molecular Biology

研究领域

Professor Aguilar has a major research program that includes the role of peptide-membrane interactions in a variety of disease states, b-amino acid-based peptidomimetics and the development of new analytical tools for isolating membrane proteins. Specific project areas include: Regulation of G protein-coupled receptors via specific interactions with the plasma membrane. Mechanism of protein misfolding in Alzheimer's disease. Design of novel ligands for the treatment of cardiovascular disease and HIV. Peptide-based vaccines for the treatment of cancer. Design of novel antimicrobial peptides.

近期论文

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Lee TH, Hirst D, and Aguilar MI, ‘New Insights into the Molecular Mechanisms of Biomembrane Structural Changes and Interactions by optical biosensor technology', BBA Biomembranes, 1848 (2015) 1868-1885. doi: 10.1016/j.bbamem.2015.05.012. Sani M-A, Lee TH, Aguilar MI* and Separovic F*, ‘Proline-15 creates an amphipathic wedge in maculatin 1.1 peptides that drives lipid membrane disruption', BBA Biomembranes, 1848 (2015) 2277-2289 .doi.org/10.1016/j.bbamem.2015.06.013. Lee TH., Hall, K, and Aguilar MI, ‘Antimicrobial Peptide Structure and Mechanism of Action: A Focus on the Role of Membrane Structure', Current Topics in Med Chem, 1848 (2015) 2277-2289. Hall, K, Lee TH, Mechler A, Swann MJ and Aguilar MI, ‘Real-time Measurement of Multiple Membrane Conformational States During Antimicrobial Peptide Binding: The Balance Between Recovery and Lysis'. Scientific Reports, June 27 4:5479 (2014). DOI: 10.1038/srep05479. Lee TH, Heng C, Separovic F and Aguilar MI, ‘Comparison of Reversible Membrane Destabilisation Induced by Antimicrobial Peptides Derived from Australian Frogs', Biochim Biophys Acta (Biomembranes), 1838 (2014) 2205-15. Hirst D, Lee TH, Swann MJ, and Aguilar MI, ‘Multi-state kinetic analysis of antimicrobial peptide-membrane interactions', Anal Chem., 85 (2013) 9296-9304. Fernandez DI, Sani M-A, Lee TH, Aguilar MI* and Separovic F*, "Proline affects the membrane insertion of the antimicrobial peptide maculatin 1.1", Biophys J, 104 (2013) 1495-1507. Fernandez DI, Le Brun AP, Lee TH, Bansal P, Aguilar MI, James M and Separovic F, "Structural Effects of the Antimicrobial Peptide Maculatin 1.1 on Supported Lipid Bilayers", Eur Biophys J, 42 (2013) 47-59. Hall K, Lee TH. Daly NL, Craik DJ, Aguilar MI, "Gly6 of Kalata B1 is critical for the selective binding to phosphatidylethanolamine membranes", BBA Biomembranes, 1818 (2012) 2354-61. Sando L, Henriques ST, Foley FT, Simonsen SM, Daly NL, Hall K, Gustafson KR, Aguilar MI and Craik DJ, ‘Circular knotted proteins: a synthetic mirror image cyclotide reveals that anti-HIV activity is mediated by affinity for membranes. ChemBioChem, 12 (2011) 2456-62. *Chosen as the Cover of the Issue.