Selemidis, Stavros - Monash University - Department of Pharmacology

研究领域

Stavros’ research is currently focused on investigating the roles of reactive oxygen species (ROS) in biological processes that underpin influenza A virus induced lung injury and cancer. His research programs provide a logical and unifying approach that will lead to the identification of cellular pathways influenced by ROS relevant to diseases caused by influenza A virus infections and cancer, the generation of novel and more selective tools to understand such processes, and the validation of these processes in appropriate cell and animal models. His recent research has made novel observations that relate specifically to the important family of enzymes now known to be the master regulators of ROS production in mammalian cells - the NADPH oxidases.

近期论文

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HARRISON IP, SELEMIDIS S. Understanding the biology of reactive oxygen species and their link to cancer: Nox oxidases as novel pharmacological targets. Clin Exp Pharmacol Physiol. 2014 Apr 17. doi: 10.1111/1440-1681.12238. [Epub ahead of print] To EE, BROUGHTON BR, HENDRICKS KS, VLAHOS R, SELEMIDIS S. Influenza A virus and TLR7 activation potentiate NOX2 oxidase-dependent ROS production in macrophages. Free Radical Research. 2014 may 29:1-23. [epub ahead of print] SELEMIDIS S, SEOW HJ, BROUGHTON BR, VINH A, BOZINOVSKI S, SOBEY CG, DRUMMOND GR, VLAHOS R. Nox1 oxidase suppresses influenza A virus-induced lung inflammation and oxidative stress. PLoS One. 2013;8(4):e60792. doi: 10.1371/journal.pone.0060792. Epub 2013 Apr 8. MILLER AA, MAXWELL KF, CHRISSOBOLIS S, BULLEN ML, KU JM, MICHAEL DE SILVA T, SELEMIDIS S, HOOKER EU, DRUMMOND GR, SOBEY CG, KEMP-HARPER BK. Nitroxyl (HNO) suppresses vascular Nox2 oxidase activity. Free Radic Biol Med. 2013 Jul;60:264-71. YATMAZ S, SEOW H.J, GUALANO R.C, WONG ZX, STAMBAS J, SELEMIDIS S, CRACK P.J, BOZINOWSKI S, ANDERSON G.P. & VLAHOS R. 2012. Glutathione peroxidase (GPx-1) reduces influenza A virus-induced lung inflammation. Am J Respir Cell Mol Biol. 2013 Jan;48(1):17-26. doi: 10.1165/rcmb.2011-0345OC. Epub 2012 Sep 20. HARRISON C.B. SELEMIDIS S, GUIDA, E, KING P, SOBEY, CG & DRUMMOND GR. (2012). Nox2; a novel splice variant of Nox2 that regulates NADPH oxidase activity in macrophages. PLoS one. 2012;7(10):e48326. doi: 10.1371/journal.pone.0048326. Epub 2012 Oct 31. COSO S, HARRISON I, HARRISON CB VINH A, SOBEY CG, DRUMMOND GR, WILLIAMS ED, SELEMIDIS S. (2012). NADPH oxidases as regulators of tumour angiogenesis: current and emerging concepts. Invited review. Antioxidants and Redox Signalling. June 1, 2012, 16(11): 1229-1247. VLAHOS R, STAMBAS S, SELEMIDIS S. (2012). Suppressing ROS production for influenza A virus therapy. Trends in Pharmacological Sciences,33 (1), 3-8, 2012. DRUMMOND GR, SELEMIDIS S, GRIENDLING KK, SOBEY CG. Combating oxidative stress in vascular disease: NADPH oxidases. Nat Rev Drug Discov. 2011 Jun;10(6):453-71