Bourke, Jane - Monash University - Department of Pharmacology

研究领域

Dr Jane Bourke is a respiratory pharmacologist whose research focuses on identifying improved therapeutic strategies in chronic lung diseases, including asthma and pulmonary hypertension. She is a Senior Lecturer in Pharmacology at Monash University, where she leads the Respiratory Pharmacology Group and currently holds a NHMRC Project Grant. Jane has a long-standing interest in the regulation of smooth muscle function in chronic diseases of the lung and cardiovascular system. She has discovered that ligands of an intracellular receptor, called peroxisome-proliferator activated receptor gamma (PPARγ) cause airways to relax under conditions where current drugs are ineffective. In collaboration with Prof Sanderson (University of Massachusetts) and A/Prof Snibson (Veterinary Science, University of Melbourne), her research group is examining multiple novel bronchodilators targeting small airways using a novel lung slice technique in which changes in airway lumen area and calcium signalling can be visualised, These drugs are being assessed in mouse and sheep models of chronic lung disease to support their future clinical development.

近期论文

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Fitzpatrick M., Donovan C., Bourke J.E. (2013). Prostaglandin E2 elicits greater bronchodilation than salbutamol in mouse intrapulmonary airways in lung slices. Pulm. Pharmacol. Ther. Nov 28. [Epub ahead of print] Bourke J.E., Bai Y., Donovan C., Esposito J.G., Tan X., Sanderson M.J. Novel small airway bronchodilator responses to rosiglitazone in mouse lung slices. Am. J. Respir. Cell Mol. Biol. Nov 4. [Epub ahead of print] Donovan C., Royce S.G., Esposito J., Tran J., Ibrahim Z.A., Tang M.L., Bailey S., Bourke J.E. (2013) Differential effects of allergen challenge on large and small airway reactivity in mice. PLoS One Sep 6;8(9):e74101. Yeganeh, B., Xia C, Movassagh, H., Koziol-White, C., Chang, Y., Al-Alwan, L., Bourke, J.E., Oliver, B.G. (2013) Emerging mediators of airway smooth muscle dysfunction in asthma. Pulm. Pharmacol. Ther. 26:105-11. Donovan, C., Tan, X., Bourke, J.E. (2012) PPARγ ligands regulate noncontractile and contractile functions of airway smooth muscle: implications for asthma therapy. PPAR Res. 2012; 809164. Bourke, J.E., Li, X., Foster, S.R., Wee, E., Dagher, H., Ziogas, J., Harris, T., Bonacci, J.V. & Stewart, A.G. (2011) Collagen remodelling by airway smooth muscle is resistant to steroids & b2-agonists. Eur. Resp. J. 37:173-82. Tan, X., Dagher, H., Hutton, C.A. & Bourke, J.E. (2010) Effects of PPAR gamma ligands on TGF-beta1-induced epithelial-mesenchymal transition in alveolar epithelial cells. Respir Res., 23;11:21. Bischof, R.J., Bourke, J.E., Hirst, S.J., Meeusen, E.N., Snibson, K.J. & Van Der Velden, J. (2009) Measurement & impact of remodeling in the lung: airway neovascularization in asthma. Proc. Am. Thorac. Soc., 6:673-7. Ward, J.E., Harris, T., Bamford, T., Mast, A., Pain, M.C.F., Robertson, C., Smallwood, D., Tran, T., Wilson, J.W. & Stewart, A.G. (2008) Proliferation is not increased in airway myofibroblasts isolated from asthmatics. Eur Respir J., 32:362-71. Clarke, D.L., Dakshinamurti, S., Larsson, A-K, Ward, J.E. & Yamasaki, A. (2007) Lipid metabolites as regulators of airway smooth muscle function. Pulm. Pharm. Ther. 22 :426-435. Burgess, J.K., Ceresa, C., Johnson, S., Kanabar, V., Moir, L.M., Nguyen, T.T.B., Oliver, B.G.G., Schuliga, M. & Ward, J.E. (2007) Tissue & matrix influences on airway smooth muscle function. Pulm. Pharm. Ther. 22:379-87. Tan, X. & Ward, J.E. (2007). Peroxisome proliferator activated receptor ligands as regulators of airway inflammation & remodeling in chronic lung disease. PPAR Research 2007:14983.