Frith, Jessica - Monash University - Department of Materials Science and Engineering

研究领域

My interests lie at the interface of biology and engineering. By combining aspects of biomaterials, stem cell biology and genomics, I hope to understand how stem cells are guided by physical cues from their surrounding microenvironment and apply this knowledge to promote the repair and regeneration of damaged body tissues, such as bone, cartilage and intervertebral disc.

近期论文

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Moorthy S, Chokkalingam A, Frith JE>, Dhawale SD, Subramaniam VP, Strounina E, Sathish EI, Yamaura K, Cooper-White JJ, Vinu A. Fluorescent and Magnetic Mesoporous Hybrid Material: A Chemical and Biological Nanosensor for Hg2+ Ions. Nature Scientific Reports, 2016 (accepted 02/02/16). Banks TA, Luckman PS, Frith JE, Cooper-White JJ. Effects of electric fields on human mesenchymal stem cell behaviour and morphology using a novel multichannel device. Integr Biol (Camb). 2015 Jun;7(6):693-712. Frith JE, Porrello ER and Cooper-White JJ. New frontiers in microRNA-based tissue regeneration. Stem Cells Transl Med. 2014 May; 3(8); 969-76. Whitworth DJ, Frith JE, Frith TJR, Ovchinnikov DA, Cooper-White JJ and Wolvetang EJ. Mesenchymal Stromal Cells derived from Canine Induced Pluripotent Stem Cells through a small molecule-based protocol exhibit efficient trilineage differentiation in PEG hydrogels. Stem Cells Dev. 2014 Dec:23 (24):3021-3033. Cameron AR, Frith JE, Gomez GA, Yap AS, Cooper-White JJ. The effect of time-dependent deformation of viscoelastic hydrogels on myogenic induction and Rac1 activity in mesenchymal stem cells. Biomaterials. 2014 Feb; 35(6):1857-68. Frith JE, Menzies DJ, Cameron AR, Ghosh P, Whitehead DL, Gronthos S, Zannettino AC, Cooper-White JJ. Effects of Bound versus Soluble Pentosan Polysulphate in PEG/HA-based Hydrogels Tailored for Intervertebral Disc Regeneration. Biomaterials. 2014 Jan; 35(4):1150-62. Li H, Frith JE, Cooper-White JJ. Modulation of stem cell adhesion and morphology via facile control over surface presentation of cell adhesion molecules. Biomacromolecules. 2014 Jan 13;15(1):43-52. Frith JE^, Titmarsh DM^, Padmanabhan H, Cooper-White JJ. Microbioreactor array screening to elucidate the role of Wnt signaling and microenvironmental factors in osteogenic differentiation of mesenchymal progenitor cells. PLoS One. 2013 Dec 23; 8(12) Frith JE, Cameron AR, Menzies DJ, Ghosh P, Whitehead DL, Gronthos S, Zannettino AC, Cooper-White JJ. An injectable hydrogel for intervertebral disc regeneration. Biomaterials. 2013 Dec; 34(37):9430-40. Chau LT, Frith JE, Mills RJ, Menzies DJ, Titmarsh DM and Cooper-White JJ. Microfluidic platforms for informed tissue scaffold development. Microfluidic Devices for Biomedical Applications. 2013; 363-387. Woodhead Publishing Ltd. Frith JE^, Mills RJ^, Hudson JE and Cooper-White JJ. Tailored Integrin-Extracellular Matrix Interactions to Direct Human Mesenchymal Stem Cell Differentiation. Stem Cells Dev. 2012 Sep 1; 21(13):2442-56. Frith JE, Jaramillo-Ferrada P, Mills R, Cameron A, Titmarsh D, Wolvetang E and Cooper-White JJ. Development of defined culture conditions for expansion of mesenchymal stromal cells for clinical applications. Stem cells and cancer stem cells: Therapeutic applications in Disease and Injury. 2012 (8):13-26. Springer. Frith JE, Mills RJ and Cooper-White JJ. Lateral spacing of adhesion peptides influences human mesenchymal stem cell behaviour. J Cell Sci. 2012 Jan 15; 125(Pt 2):317-27.