个人简介
招生专业
071007-遗传学
071008-发育生物学
071010-生物化学与分子生物学
招生方向
鱼类遗传学
鱼类发育生物学
鱼类营养物质代谢的生理生化调控
工作经历
2015年3月-2018年12月 中国科学院水生生物研究所 助理研究员
2019年1月 至今 中国科学院水生生物研究所 副研究员
目前已在Molecular and Cellular Biology、Endocrinology、American Journal of Physiology-Endocrinology and Metabolism等SCI刊物以第一/通讯作者发表论文8篇（含等同）。
科研活动
参加国际斑马鱼大会、比较内分泌大会等会议，并做了口头报告或海报展示。
合作情况
与瑞典OREBRO UNIVERSITY的Ajay Prandial合作，进行类固醇激素-睾酮调控脑部基因表达的机制研究。
研究领域
鱼类遗传学与分子育种。目前主要从事鲤科模式鱼类-斑马鱼和鲤科养殖鱼类-鲤鱼的性腺发育和性别分化的机制研究。通过在斑马鱼中阻断类固醇激素的合成（敲除cyp17a1），构建了雄激素和雌激素缺乏的模型和“全雄性”纯合子群体，发现了鱼类中存在垂体Fshβ在精巢发育/精子发生中的补偿机制、雌激素对卵巢发育的可塑机制和雄激素对第二性征的维持机制。同时，我们拟将阻断类固醇激素合成的策略在鲤鱼中进行水产应用，通过在养殖鱼类鲤鱼中完成性别控制育种（培育遗传上“全雌”的黄河鲤），最终实现增产。另外，还发现胰岛素受体 a促进糖转换成脂肪的过程，而胰岛素受体b通过激活生长激素信号通路，进而促进脂肪的利用和蛋白质的合成等。
近期论文
查看导师新发文章
（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）
1. Zhai G, Gu Q, He J, Lou Q, Chen X, Jin X, Bi E, Yin Z. 2014. Sept6 is required for ciliogenesis in Kupffer's vesicle, the pronephros, and the neural tube during early embryonic development. Molecular and Cellular Biology 34(7), 1310-1321.
2. Zhai G, Shu T, Xia Y, Lu Y, Shang G, Jin X, He J, Nie P, Yin Z. 2018 Characterization of Sexual Trait Development in cyp17a1-Deficient Zebrafish. Endocrinology (2018) 159(10):3549-62.
3. Zhai G, Song J, Shu T, Yan J, Jin X, He J, Yin Z. 2017. LRH-1 senses signaling from phosphatidylcholine to regulate the expansion growth of digestive organs via synergy with Wnt/β-catenin signaling in zebrafish. Journal of Genetics and Genomics 44 (6): 307-317.
4. Yang B1, Zhai G1, Gong Y1, Su J, Peng X, Shang G, Han D, Jin J, Liu H, Du Z, Yin Z., Xie S. 2018. Different physiological roles of insulin receptors in mediating nutrient metabolism in zebrafish. American Journal of Physiology - Endocrinology and metabolism 315, E38-E51.
5. Zhai G1, Shu T1, Xia Y, Jin X, He J, Yin Z. 2017. Androgen signaling regulates the transcription of anti-Müllerian hormone via synergy with SRY-Related Protein SOX9A. Science Bulletin 62 (3):197-203.
6. Yang B1, Zhai G1, Gong Y, Su J, Han D, Yin Z, Xie S. 2017. Depletion of insulin receptors leads to β-cell hyperplasia in zebrafish. Science Bulletin 62 (7):486-492.
7. Gong Y1, Zhai G1, Su J, Yang B, Jin J, Liu H, Yin Z, Xie S, Han D. 2018. Different roles of insulin receptor a and b in maintaining blood glucose homeostasis in zebrafish. General and Comparative Endocrinology 269:33-45.
8. Shu T, Shu Y, Gao Y, Jin X, He J, Zhai G#, Yin Z#. 2018. Depletion of tissue-specific ion transporters causes differential expression of PRL targets in response to increased levels of endogenous PRL. Frontiers in Endocrinology 9, 683.
9. Peng X, Shang G, Wang W, Chen X, Lou Q, Zhai G, Li D, Du Z, Ye Y, Jin X, He J, Zhang Y, Yin Z. 2017. Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1alpha,25(OH)2D3. Cell Reports 19, 1444-1455.
10. Li D, Lou Q, Zhai G, Peng X, Cheng X, Dai X, Zhuo Z, Shang G, Jin X, Chen X, Han D, He J, Yin Z. 2014. Hyperplasia and cellularity changes in IGF-1-overexpressing skeletal muscle of crucian carp.
Endocrinology 155 (6):2199-2212.
11. Gao Y, Dai Z, Shi C, Zhai G, Jin X, He J, Lou Q, Yin Z. 2016. Depletion of Myostatin b Promotes Somatic Growth and Lipid Metabolism in Zebrafish. Frontiers in Endocrinology 7, 88.
12. Yang J, Li Z, Gan X, Zhai G, Gao J, Xiong C, Qiu X, Wang X, Yin Z, Zheng, F. 2016. Deletion of Pr130 Interrupts Cardiac Development in Zebrafish. International Journal of Molecular Sciences 17 (11): 1746.
13. Dai X, Shu Y, Lou Q, Tian Q, Zhai G, Song J, Lu S, Yu H, He J, Yin Z. 2017. Tdrd12 Is Essential for Germ Cell Development and Maintenance in Zebrafish. International Journal of Molecular Sciences 18 (6), 1127.
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