Tretyakova, Natalia Y. - University of Minnesota Twin Cities

个人简介

2002 –2013 "Sequence distribution of tobacco carcinogen-DNA adducts" (NCI 5R01 CA-095039) Research Project Grant from the NIH. 2003 –2013 "DNA cross-linking by diepoxybutane" (NIH NCI 2R01-CA100670) Research Project Grant from the NIH. 2010-2014 "Mechanisms of ethnic/racial differences in lung cancer due to cigarette smoking"(1 P01 CA138338-01A1) Program Project Grant from the NIH.

近期论文

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Kotandeniya, D., Murphy, D., Yan, S., Park, S., Seneviratne, U., Koopmeiners, J.S., Pegg, A., Kanugula, S., Kassie, F., Tretyakova, N.Y. (2013) Kinetics of O6-pyridyloxobutyl-2'-deoxyguanosine repair by human O6-alkylguanine DNA alkyltransferase. Biochemistry 52, 4075-4088. . Tretyakova, N.Y., Villalta, P.W., Kotapati, S. (2013) Mass spectrometry of structurally modified DNA. Chem. Rev. 113, 2395-2436. . Gherezghiher, T.B., Ming, X., Villalta, P.W., Campbell, C., Tretyakova, N.Y. (2013) 1,2,3,4-Diepoxybutane-induced DNA-protein cross-linking in human fibrosarcoma (HT1080) cells. J. Proteome. Res. 12, 2151-2164. . Wickramaratne, S., Mukherjee, S., Villalta, P.W., Scharer, O.D., Tretyakova, N.Y. (2013) Synthesis of sequence-specific DNA-protein conjugates via a reductive amination strategy. Bioconjug. Chem. 24, 1496-1506. . Kotapati, S., Maddukuri, L., Wickramaratne, S., Seneviratne, U., Goggin, M., Pence, M., Villalta, P., Guengerich, F. Marnett, L., Tretyakova, N.Y. (2012) Translesion synthesis across 1,N6-(2-Hydroxy-3-hydroxy-methylpropan-1,3-diyl)-2'-deoxyadenosine (1,N6-γ-HMHP-dA) adducts by human and archebacterial DNA polymerases. J. Biol. Chem. 287, 38800-38811. . Tretyakova, N.Y., Goggin, M., Sangaraju, D, Janis, G. (2012) Quantitation of DNA adducts by stable isotope dilution mass spectrometry. Chem. Res. Toxicol. 25, 2007-2035. Sangaraju, D., Goggin, M., Walker, V., Swenberg, J., Tretyakova, N.Y. (2012) NanoHPLC-nanoESI+-MS/MS quantitation of bis-N7-guanine DNA-DNA cross-links in tissues of B6C3F1 mice exposed to sub-ppmlevels of 1,3-butadiene. Anal. Chem., 84(3), 1732-1739. Kotandeniya, D., Murphy, D., Seneviratne, U., Guza, R., Pegg, A., Kanugula, S., Tretyakova, N.Y. (2011) Mass spectrometry based approach to study the kinetics of O6-alkylguanine DNA alkyltransferase-mediated repair of O6-pyridyloxobutyl-2'-deoxyguanosine adducts in DNA. Chem. Res. Toxicol. 24(11), 1966-1975. Kotapati, S., Matter, B.A., Grant, A.L., Tretyakova, N.Y. (2011) Quantitative analysis of trihydroxybutyl mercapturic acid, a urinary metabolite of 1,3-butadiene, in human. Chem. Res. Toxicol. 24(9), 1516-1526. Goggin, M., Sangaraju, D., Walker, V.E., Wickliffe, J., Swenberg, J.A., Tretyakova, N.Y. (2011) Persistence and repair of bifunctional DNA adducts in tissues of laboratory animals exposed to 1,3-butadiene by inhalation. Chem. Res. Toxicol. 24, 809-817. Swenberg, J.A., Bordeerat, N.K., Boysen, G., Carro, S., Georgieva, N.I., Nakamura, J., Troutman, J.M., Upton, P.B., Albertini, R.J., Vacek, P.M., Walker, V.E., Sram, R.J., Goggin, M., Tretyakova, N.Y. (2011) 1,3-Butadiene: Biomarkers and application to risk assessment. Chem. Biol. Interact. 192, 150-154. Kotandeniya, D., Murphy, D., Seneviratne, U., Guza, R., Pegg, A., Kanugula, S., Tretyakova N.Y. (2011) Mass spectrometry based approach to study the kinetics of O6-alkylguanine DNA alkyltransferase mediated repair of O6-pyridyloxobutyl-2'-deoxyguanosine adducts in DNA. Chem. Res. Toxicol. 24, 1966-75. Johnson, L,A., Malayappan, B., Tretyakova, N.Y., Campbell, C., Macmillan, M.L., Wagner, J.E., Jacobson, P.A. (2012) Formation of cyclophosphamide specific DNA adducts in hematological diseases. Pediatr. Blood Cancer. 58, 708-14. Kotapati, S., Matter, B.A., Grant, A.L., Tretyakova, N.Y. (2011) Quantitative analysis of trihydroxybutyl mercapturic acid, a urinary metabolite of 1,3-butadiene, in humans. Chem. Res. Toxicol. 24, 1516-1526. Michaelson-Richie, E,D., Ming. X., Codreanu, S.G., Loeber, R.L., Liebler, D.C., Campbell, C., Tretyakova, N.Y. (2011) Mechlorethamine-induced DNA-protein cross-linking in human fibrosarcoma (HT1080) cells. J. Proteome Res. 10, 2785-2796. Guza, R., Kotandeniya, D., Murphy, K., Dissanayake, T., Lin, C., Giambasu, G.M., Lad, R.R., Wojciechowski, F., Amin, S., Sturla, S.J., Hudson, R.H., York, D.M., Jankowiak, R., Jones, R., Tretyakova, N.Y. (2011) Influence of C-5 substituted cytosine and related nucleoside analogs on the formation of benzo[a]pyrene diol epoxide-dG adducts at CG base pairs of DNA. Nucleic Acids Res. 39, 3988-4006. Seneviratne, U., Antsypovich, S., Quirk Dorr, D., Dissanayake, T., and Tretyakova, N.Y. (2010) DNA oligomers containing site- and stereospecific exocyclic deoxyadenosine adducts of 1,2,3,4-diepoxybutane: synthesis, characterization, and effects on DNA structure. Chem. Res. Toxicol. 23, 1556-1567. Michaelson-Richie, E., Loeber, R., Fang, Q., Campbell, C., Pegg, A., and Tretyakova, N.Y. (2010) DNA-protein cross-linking by 1,2,3,4-diepoxybutane. J. Proteome Res. 9, 4356-4367. Seneviratne U., Antsypovich S., Goggin M., Dorr D.Q., Guza R., Moser A., Thompson C., York D.M. and Tretyakova, N.Y. (2010) Exocyclic deoxyadenosine adducts of 1,2,3,4-diepoxybutane: synthesis, structural characterization, and mechanistic studies. Chem. Res. Toxicol. 23, 118-133 (highlighted article). Goggin, M., Seneviratne, U., Swenberg, J.A., Walker, V., and Tretyakova, N.Y. (2010) Column switching HPLC-ESI+-MS/MS methods for quantitative analysis of exocyclic dA adducts in the DNA of laboratory animals exposed to 1,3-butadiene. Chem. Res. Toxicol. 23, 808-812.