个人简介

B.Sc 1991, Chemistry with Honors, NM Inst. of Mining & Technology Ph.D. 1996, Organic Chemistry, University of Arizona C. S. Marvel Fellow, 1996-1997 Post-Doctoral Research Fellow 1997, Bioorganic Chemistry, MIT N.I.H. Post Doctoral Fellow, 1998-2000, Sloan-Kettering Lawrence and Selma Ruben Fellow, 2000-2001, Sloan-Kettering Awards & Honors Rutgers, The State University of New Jersey, Piscataway, NJ J.L.R. Morgan Chair of Synthetic Chemistry, 2001-2006 J. & J. Discovery Award, 2003-2005 Distinguished Contributions to Undergraduate Teaching, 2005 Sloan-Kettering Institute for Cancer Research, New York, NY Lawrence and Selma Ruben Fellowship, 2000-2001 N.I.H. Post Doctoral Fellowship, 1998-2000 The University of Arizona, Tucson, AZ C. S. Marvel Fellowship, 1996-1997 Gregson Scholarship, 1995-1996 Graduate Research Fellowship, summer 1994 Graduate Academic Scholarship, 1992-1994 New Mexico Institute of Mining and Technology, Socorro, NM Regents Scholarship, 1987-1991

研究领域

Organic Chemistry

Computational & experimental mechanistic studies. New reaction discovery and method development. Synthesis of functional materials, including complex bio-active and natural products. Our research addresses a broad spectrum of problems at the interface of synthetic organic chemistry and biology. What inspires our work is the obsession with the idea that what has already been said about synthesis is still not enough. Thus in each of our projects we set out to demonstrate new - or to explore poorly understood - principles of chemical reactivity. Since we consider natural product total synthesis an opportunity to gain knowledge, our efforts in total synthesis are never finished they simply stop at interesting places. Total synthesis as a tool for exploring biological activity Our interests in medicine are derived from the profoundly selective events that many sophisticated organic molecules trigger in multi-cellular organisms. Hence, the synthesis of bioactive organic molecules enables complex biological processes to be scrutinized. In our current researches on the preparation and elaboration of non-ribosomal peptide, polyketide, and terpene natural products, each target has tantalizing, and only partially understood biological activity. In all research we strive to maintain a global view of the relevance of our studies to science and medicine in general. For example, we actively seek out targets relevant to oncology and immunology. Indeed, what begins as a precise question regarding chemical reactivity and the subtle interplay between reactivity and molecular structure, proceeds with investigating the molecular requirements of biological activity and medicinal applications with the goal to register an advance in disease management.

近期论文

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Hoang, T. T.; Dudley, G. B.; Williams, L. J. "Fragmentation Reactions." In Comprehensive Organic Synthesis, 2nd Edition; Molander, G., Knochel, P., Eds.; Elsevier: Oxford, 2014; Vol. 6, Chap. 30, 842. Michael A. Drahl, Madhuri Manpadi and Lawrence J. Williams. "C-C Fragmentation: Origins and Recent Applications." Angew. Chem. Int. Ed. 2013, 52, 11222. Rojita Sharma and Lawrence J. Williams. "Oxetan-3-ones from Allenes via Spirodiepoxides." Org. Lett. 2013, 15, 2202. Kai Liu, Hiyun Kim, Partha Ghosh, Novruz G. Akhmedov and Lawrence J. Williams. "Direct Entry to Erythronlolides via a Cyclic Bis[Allene]." J. Am. Chem. Soc. 2011, 133, 14968. Williams, L. J.; Drahl, M. A.; Manpadi, M. Synthetic Methods and Intermediates for the Preparation of Xenicanes. U.S. Patent Pending, 2011. Williams, L. J.; Liu, K.; Kim, H.; Sharma, R. Macrolide Compounds and Methods and Intermediates Useful for Their Preparation. U.S. Patent Pending, 2011. Da Xu, Michael A. Drahl and Lawrence J. Williams. "Toward an Integrated Route to the Vernonia Allenes and Related Sesquiterpenoids." Beilstein J. Org. Chem. 2011, 7, 937. Rojita Sharma, Madhuri Manpadi, Yue Zhang, Hiyun Kim, Novruz G. Ahmedov and Lawrence J. Williams. "Spirodiepoxide-Based Cascades: Direct Access to Diverse Motifs." Org. Lett. 2011, 13, 3352. Michael A. Drahl, Novruz G. Akhmedov and Lawrence J. Williams. "Selective Conversion of an Enantioenriched Cyclononadienone to the Xeniolide, Xenibellol, and Florlide Cores: An Integrated Routing Strategy." Tetrahedron Lett. 2011, 52, 325. Robert V. Kolakowski and Lawrence J. Williams. "Stereoinduction by Distortional Asymmetry." Nature Chem. 2010, 2, 303. Sipak Joyasawal, Stephen D. Lotesta, N. G. Akhmedov and Lawrence J. Williams. "Spirodiepoxide Strategy to the C Ring of Pectenotoxin 4: Synthesis of the C1-C19 Sector." Org. Lett. 2010, 12, 988. Jongjin Jung, Aniruddh Solanki, Kevin A. Memoli, Ken-ichiro Kamei, Hiyun Kim, Michael A. Drahl, Lawrence J. Williams, Hsian-Rong Tseng and KiBum Lee. "Selective Inhibition of Human Brain Tumor Cells through Multifunctional Quantum-Dot-Based siRNA Delivery." Angew. Chem. Int. Ed. 2010, 49, 103. Partha Ghosh, Joseph R. Cusick, Jennifer Inghrim and Lawrence J. Williams. "Silyl-Substituted Spirodiepoxides: Stereoselective Formation and Regioselective Opening." Org. Lett. 2009, 11, 4672. Yue Zhang, Joseph R. Cusick, Partha Ghosh, Ning Shangguan, Sreenivas Katukojvala, Jennifer Inghrim, Thomas J. Emge and Lawrence J. Williams. "Spirodiepoxides: Synthesis of Epoxomicinoids." J. Org. Chem. 2009, 74, 7707. Partha Ghosh, Yue Zhang, Thomas J. Emge and Lawrence J. Williams. "Modeling a Macrocyclic Bis[spirodiepoxide] Strategy to Erythronolide A." Org. Lett. 2009, 11, 4402. Robert V. Kolakowski, Madhuri Manpadi, Yue Zhang, Thomas J. Emge and Lawrence J. Williams. "Allene Synthesis via C−C Fragmentation: Method and Mechanistic Insight." J. Am. Chem. Soc. 2009, 131, 12910. Yue Zhang, Stephen D. Lotesta, Thomas J. Emge and Lawrence J. Williams. "Structure and Reactivity of a Chiral Cyclononadienone." Tetrahedron Lett. 2009, 10, 1882. Gaojie Hu, Kai Liu and Lawrence J. Williams. "The Brosimum Allene: A Structural Revision." Org. Lett. 2008, 10, 5493. Hiyun Kim and Lawrence J. Williams. "Recent Developments in Allene-based Synthetic Methods." Curr. Opin. Drug Discovery Dev. 2008, 11, 870. Zhenghua Wang, Ning Shangguan, Joseph R. Cusick and Lawrence J. Williams. "Controlled Acid-Induced Rearrangement of a Spirodiepoxide." Synlett 2008, 2, 213.