研究领域

Computational and Systems Biology (Mathematical biology) Micro-RNAs in epithelial-mesenchymal plasticity (Data enrichment with knowledge bases) Proteomics: Immunofluorescence labelling with confocal microscopy; tandem mass spectrometry (Quantitative proteomics) Quantitative Imaging and Image Processing (Confocal microscopy, quantitative proteomics)

My current research interests are directed towards intracellular signalling processes and their role in regulating cell behaviour to promote tissue function. Professional Specialty: Systems Biology Experience in the application of statistical metrics to analyse protein abundance data, including Pearson correlation and mutual information, and experience in the application of Bayesian network inference methods to analyse protein abundance data.   Professional Specialty: Proteomics Experience in measuring protein abundance using tandem mass spectrometry, western blotting, and immunofluorescence labelling with confocal microscopy. Particular focus on measuring protein abundance within tissue samples. Professional Specialty: Quantitative Imaging and Image Processing Application of confocal microscopy to achieve a quantitative imaging protocol, and image processing to obtain protein abundance data from confocal microscope image data. Professional Specialty: micro-RNAs Much of my work over recent years has focused on investigating the role of micro-RNAs in regulating epithelial-mesenchymal plasticity programs, within breast cancer and melanoma. This involves integration of various databases for the large-scale analysis of mRNA and miR transcript abundance data, and the development of specialised mathematical/computational methods to examine post-transcriptional regulation exerted by micro-RNAs.

近期论文

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Waltemath D, Karr J, Bergmann F, Chelliah V, Hucka M, Krantz M, Liebermeister W, Mendes P, Myers C, Pir P, Alaybeyoglu B, Aranganathan N, Baghalian K, Bittig A, Burke P, Cantarelli M, Chew Y, Costa R, Cursons J, Czauderna T, Goldberg A, Gomez H, Hahn J, Hameri T, Gardiol D, Kazakiewicz D, Kiselev I, Knight-Schrijver V, Knupfer C, Konig M, Lee D, Lloret-Villas A, Mandrik N, Medley J, Moreau B, Naderi-Meshkin H, Palaniappan S, Priego-Espinosa D, Scharm M, Sharma M, Smallbone K, Stanford N, Song JH, Theile T, Tokic M, Tomar N, Toure V, Uhlendorf J, Varusai T, Watanabe L, Wendland F, Wolfien M, Yurkovich J, Zhu Y, Zardilis A, Zhukova A, Schreiber F. Toward community standards and software for whole-cell modeling.. IEEE Trans Biomed Eng. IEEE - Institute of Electrical and Electronic Engineers. 2016. Gawthrop P, Cursons J, Crampin E. Hierarchical bond graph modelling of biochemical networks. PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES. The Royal Society of London. 2015, Vol. 471, Issue 2184. Hurley D, Cursons J, Wang YK, Budden D, Print CG, Crampin E. NAIL, a software toolset for inferring, analyzing and visualizing regulatory networks. BIOINFORMATICS. Oxford University Press. 2015, Vol. 31, Issue 2. Cursons J, Gao J, Hurley D, Print CG, Dunbar PR, Jacobs MD, Crampin E. Regulation of ERK-MAPK signaling in human epidermis. BMC SYSTEMS BIOLOGY. Biomed Central. 2015, Vol. 9. Cursons J, Angel CE, Hurley D, Print CG, Dunbar PR, Jacobs MD, Crampin E. Spatially transformed fluorescence image data for ERK-MAPK and selected proteins within human epidermis. GIGASCIENCE. Biomed Central. 2015, Vol. 4. Cursons J, Leuchowius K, Waltham M, Tomaskovic-Crook E, Foroutan M, Bracken CP, Redfern A, Crampin E, Street I, Davis M, Thompson E. Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines. CELL COMMUNICATION AND SIGNALING. Biomed Central. 2015, Vol. 13. Budden D, Hurley D, Cursons J, Markham J, Davis M, Crampin E. Predicting expression: the complementary power of histone modification and transcription factor binding data. EPIGENETICS & CHROMATIN. Biomed Central. 2014, Vol. 7. Cursons J, Hurley D, Angel CE, Dunbar PR, Crampin E, Jacobs MD. Inference of an in situ epidermal intracellular signaling cascade. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Press. 2010, Vol. 2010. Cursons J, Hurley D, Angel CE, Dunbar R, Crampin E, Jacobs MD. Inference of an in situ epidermal intracellular signaling cascade.. Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. Institute of Electrical and Electronics Engineers. 2010.