Seidel, Daniel - University of Florida - Department of Chemistry

个人简介

Daniel received his Diplom from the Friedrich-Schiller Universität at Jena in 1998, after having completed his fifth and final year of the program at the University of Texas at Austin as a fellow of the Trans Atlantic Student Exchange program. He returned to Austin to perform his graduate Studies in the lab of Prof. Jonathan L. Sessler, obtaining his Ph.D. in 2002 for the development of new methods for the synthesis of expanded porphyrin analogues. From 2002–2005, Daniel was an Ernst Schering Postdoctoral Fellow in the group of Prof. David A. Evans at Harvard University, focusing on the development of new metal catalysts for catalytic enantioselective transformations. He started his independent career at Rutgers University in August of 2005, was promoted to Associate Professor in 2011 and to Professor in 2014. In 2017, his group moved to the University of Florida.

研究领域

Current research efforts are focused on the development of practical new methods for C–H bond functionalization and the exploration of new concepts for asymmetric catalysis, including organocatalysis, transition metal catalysis, and multicomponent catalysis.

近期论文

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“Palladium-Catalyzed Arylation of Endocyclic 1-Azaallyl Anions: Concise Synthesis of Unprotected Enantioenriched cis-2,3-Diarylpiperidines.” Biao Zhang, Junhao Ruan, Daniel Seidel, and Weijie Chen, Angew. Chem. Int. Ed. 2023, e202307638. “Degradation of Polyacrylates by One-Pot Sequential Dehydrodecarboxylation and Ozonolysis.” Angie B. Korpusik, Alafate Adili, Kamal Bhatt, Jacqueline E. Anatot, Daniel Seidel, and Brent S. Sumerlin, J. Am. Chem. Soc. 2023, 145, 10480–10485. “Synthesis of Polycyclic Imidazoles via α-C–H/N–H Annulation of Alicyclic Amines.” Subhradeep Dutta, Kamal Bhatt, Fabian Cuffel, and Daniel Seidel, invited contribution for special issue dedicated to the memory of Prof. David A. Evans, Synthesis 2023, 55, 2343–2352. “Mechanism of a Dually Catalyzed Enantioselective Oxa-Pictet–Spengler Reaction and the Development of a Stereodivergent Variant.” Alafate Adili, John-Paul Webster, Chenfei Zhao, Sharath Chandra Mallojjala, Moises A. Romero-Reyes, Ion Ghiviriga, Khalil A. Abboud, Mathew J. Vetticatt, and Daniel Seidel, ACS Catal. 2023, 13, 2240–2249. “N-Fluorenyl Tryptamines as a Useful Platform for Catalytic Enantioselective Pictet–Spengler Reactions.” Alafate Adili, Aniket Sole, Bishwaprava Das, Megan E. Matter, and Daniel Seidel, invited contribution for special issue in honor of Prof. Cristina Nevado, Synthesis 2023, 55, 1724–1735. “Probing the Free Energy Landscape of Organophotoredox-Catalyzed Anti-Markovnikov Hydrofunctionalization of Alkenes.” Sharath Chandra Mallojjala, Victor O. Nyagilo, Stephanie A. Corio, Alafate Adili, Anuradha Dagar, Kimberly A. Loyer, Daniel Seidel, and Jennifer S. Hirschi, J. Am. Chem. Soc. 2022, 144, 17692–17699. “Regioselective α-Cyanation of Unprotected Alicyclic Amines.” Fuchao Yu, Daniel A. Valles, Weijie Chen, Scott D. Daniel, Ion Ghiviriga, and Daniel Seidel, Org. Lett. 2022, 24, 6364–6368. “Photocatalytic Direct Decarboxylation of Carboxylic Acids to Derivatize or Degrade Polymers.” Alafate Adili, Angie B. Korpusik, Daniel Seidel, and Brent S. Sumerlin, Angew. Chem. Int. Ed. 2022, e202209085. “Synthesis of Polycyclic Isoindolines via α-C–H/N–H Annulation of Alicyclic Amines.” Anirudra Paul, Camille Vasseur, Scott D. Daniel, and Daniel Seidel, Org. Lett. 2022, 24, 1224–1227. “Condensation-Based Methods for the C–H Bond Functionalization of Amines.” Weijie Chen and Daniel Seidel, Synthesis 2021, 53, 3869–3908. “C–H Bond Functionalization of Amines: A Graphical Overview of Diverse Methods.” Subhradeep Dutta, Bowen Li, Dillon R. L. Rickertsen, Daniel A. Valles, and Daniel Seidel, SynOpen 2021, 5, 173–228. “α,α′-C–H Bond Difunctionalization of Unprotected Alicyclic Amines.” Daniel A. Valles, Subhradeep Dutta, Anirudra Paul, Khalil A. Abboud, Ion Ghiviriga, and Daniel Seidel, Org. Lett. 2021, 23, 6367–6371. “α-C–H/N–H Annulation of Alicyclic Amines via Transient Imines: Preparation of Polycyclic Lactams.” Weijie Chen and Daniel Seidel, Org. Lett. 2021, 23, 3729–3734. “α-C–H Bond Functionalization of Unprotected Alicyclic Amines: Lewis Acid Promoted Addition of Enolates to Transient Imines.” Jae Hyun Kim, Anirudra Paul, Ion Ghiviriga, and Daniel Seidel, Org. Lett. 2021, 23, 797–801. “Diversification of unprotected alicyclic amines via C–H bond functionalization: Decarboxylative alkylation of transient imines.” Anirudra Paul, Jae Hyun Kim, Scott D. Daniel, and Daniel Seidel Angew. Chem. Int. Ed. 2021, 60, 1625–1628. “Traceless Redox-Annulations of Alicyclic Amines with a Nitro Directing Group.” Dillon R. L. Rickertsen, Longle Ma, Anirudra Paul, Khalil A. Abboud, and Daniel Seidel, SynOpen 2020, 4, 123−131. “Modular Design of Chiral Conjugate-Base-Stabilized Carboxylic Acids: Catalytic Enantioselective [4+2] Cycloadditions of Acetals.” Zhengbo Zhu, Minami Odagi, Nantamon Supantanapong, Weici Xu, Jaan Saame, Helmi-Ulrika Kirm, Khalil A. Abboud, Ivo Leito, and Daniel Seidel, J. Am. Chem. Soc. 2020, 142, 15252−15258. “Rapid Functionalization of Multiple C–H Bonds in Unprotected Alicyclic Amines.” Weijie Chen, Anirudra Paul, Khalil A. Abboud, and Daniel Seidel, Nat. Chem. 2020, 12 “A Selenourea-Thiourea Brønsted Acid Catalyst Facilitates Asymmetric Conjugate Additions of Amines to α,β-Unsaturated Esters.” Yingfu Lin, William J. Hirschi, Anuj Kunadia, Anirudra Paul, Ion Ghiviriga, Khalil A. Abboud, Rachael W. Karugu, Mathew J. Vetticatt, Jennifer S. Hirschi, and Daniel Seidel, J. Am. Chem. Soc. 2020, 142, ASAP. “Redox-Annulations of Cyclic Amines with ortho-Cyanomethylbenzaldehydes.” Anirudra Paul, Hemant S. Chandak, Longle Ma, and Daniel Seidel, Org. Lett. 2020, 22, 976–980. “Highly Acidic Conjugate-Base-Stabilized Carboxylic Acids Catalyze Enantioselective oxa-Pictet–Spengler Reactions with Ketals.” Zhengbo Zhu, Minami Odagi, Chenfei Zhao, Khalil A. Abboud, Helmi Ulrika Kirm, Jaan Saame, Märt Lõkov, Ivo Leito, and Daniel Seidel, Angew. Chem. Int. Ed. 2020, 59, 2028–2032. “Catalytic Enantioselective Approaches to the oxa-Pictet–Spengler Cyclization and Other 3,6-Dihydropyran-Forming Reactions.” Zhengbo Zhu, Alafate Adili, Chenfei Zhao, and Daniel Seidel, SynOpen 2019, 3, 77–90. “α-Functionalization of Cyclic Secondary Amines: Lewis Acid Promoted Addition of Organometallics to Transient Imines.” Anirudra Paul and Daniel Seidel, J. Am. Chem. Soc. 2019, 141, 8778−8782. “Redox-Annulations of Cyclic Amines with Electron-Deficient o-Tolualdehydes.” Anirudra Paul, Alafate Adili, and Daniel Seidel, Org. Lett. 2019, 21, 1845−1848. “Insights into the Structure and Function of a Chiral Conjugate-Base-Stabilized Brønsted Acid Catalyst.” Minami Odagi, Hiroshi Araki, Chang Min, Eri Yamamoto, Thomas J. Emge, Masahiro Yamanaka, and Daniel Seidel, invited contribution for special issue on organic reaction mechanisms, Eur. J. Org. Chem. 2019, 486–492. “Chiral Bisoxazoline Ligands Designed to Stabilize Bimetallic Complexes.” Deepankar Das, Rudrajit Mal, Nisha Mittal, Zhengbo Zhu, Thomas J. Emge, and Daniel Seidel, Beilstein J. Org. Chem. 2018, 14, 2002–2011. “Redox-Annulations of Cyclic Amines with 2-(2-Oxoethyl)Malonates.” Zhengbo Zhu, Hemant S. Chandak, and Daniel Seidel, Org. Lett. 2018, 20, 4090–4093. “Formal [4+2] Cycloadditions of Imines With Alkoxyisocoumarins.” Claire L. Jarvis, Neyra M. Jemal, Spencer Knapp, and Daniel Seidel, Org. Biomol. Chem. 2018, 16, 4231–4235. “Decarboxylative Annulation of α-Amino Acids with β-Ketoaldehydes.” Anirudra Paul, N. R. Thimmegowda, Thiago Galani Cruz, and Daniel Seidel, Org. Lett. 2018, 20, 602–604. “Direct α-Functionalization of Unprotected Cyclic Amines.” Weijie Chen, Longle Ma, Anirudra Paul and Daniel Seidel Nat. Chem. 2018, 10, 165–169. “Synthesis of Polycyclic Imidazolidinones via Amine Redox-Annulation.” Zhengbo Zhu, Xin Lv, Jason Anesini and Daniel Seidel, Org. Lett. 2017, 19, 6424–6427. “Catalytic Enantioselective Synthesis of Mariline A and Related Isoindolinones via a Biomimetic Approach.” Chang Min, Yingfu Lin and Daniel Seidel, Angew. Chem. Int. Ed. 2017, 56, 15353–15357. “Identification of A Strong and Specific Antichlamydial N-Acylhydrazone.” Huirong Zhang, Anuj Kunadia, Yingfu Lin, Zheng Gong, Joseph Fondell, Daniel Seidel and Huizhou Fan PLoS ONE 2017, 12, e0185783. “Reductive Etherification via Anion-Binding Catalysis.” Chenfei Zhao, Christopher A. Sojdak, Wazo Myint and Daniel Seidel J. Am. Chem. Soc. 2017, 139, 10224−10227. “Asymmetric Brønsted Acid Catalysis with Chiral Carboxylic Acids.” Chang Min and Daniel Seidel Chem. Soc. Rev. 2017, 46, 5889−5902. “Acetic Acid Promoted Redox Annulations with Dual C−H Functionalization.” Zhengbo Zhu and Daniel Seidel Org. Lett. 2017, 19, 2841–2844. “Catalytic Enantioselective Synthesis of Lactams via Formal [4+2] Cycloaddition of Imines With Homophthalic Anhydride.” Claire L. Jarvis, Jennifer S. Hirschi, Mathew J. Vetticatt and Daniel Seidel Angew. Chem. Int. Ed. 2017, 56, 2670–2674.