个人简介
招生专业
070302-分析化学
招生方向
同步辐射生物成像分析
工作简历
2018-10~现在, 中国科学院上海高等研究院, 研究员
2016-12~2018-10,中国科学院上海应用物理研究所, 研究员
2012-12~2016-12,中国科学院上海应用物理研究所, 副研究员
2008-07~2012-12,中国科学院上海应用物理研究所, 助理研究员
教授课程
纳米生物技术:概念、应用和前景
专利成果
( 1 ) 一种碳纳米材料细胞毒性的测定方法, 2010, 第 1 作者, 专利号: ZL200710039533.0
( 2 ) 一种碳纳米材料-免疫刺激序列复合物的制备方法及其应用, 2016, 第 1 作者, 专利号: ZL201310116820.2
( 3 ) 一种同步X射线可见的成像标签及其制备方法, 2019, 第 2 作者, 专利号: ZL201710228701.4
( 4 ) 一种基于同步光源的X-射线遗传标记探针及其制备方法以及应用, 2020, 第 2 作者, 专利号: ZL201710228597.9
( 5 ) 一种磁性纳米材料介导的CRISPR/Cas9 T细胞内递送系统及其制备方法和应用, 2020, 第 2 作者, 专利号: ZL201710728571.0
发表著作
Synchrotron-based Bioimaging in Cells and in Vivo, Wiley-VCH, 2018-04, 第 1 作者
Synchrotron-based X-ray Microscopes for Nanoscale Bioimaging, Wiley-VCH, 2018-04, 第 1 作者
科研项目
( 1 ) PM2.5细颗粒毒性机制研究, 主持, 国家级, 2013-01--2016-12
( 2 ) 纳米金刚石-Gd-As2O3复合药物抗肝癌效应的同步辐射研究, 主持, 国家级, 2013-01--2015-12
( 3 ) 基于上海同步辐射光源的高分辨X射线显微技术在细胞成像中的应用, 主持, 省级, 2014-07--2016-06
( 4 ) 多种显微图像的融合,亚细胞结构的识别和定位研究, 主持, 国家级, 2012-01--2016-08
( 5 ) 大气细颗粒物诱发呼吸系统自噬功能紊乱的机制研究, 主持, 国家级, 2017-01--2020-12
( 6 ) 高品质同步辐射X射线遗传标记探针的制备, 主持, 部委级, 2017-01--2021-12
( 7 ) 细胞内纳米尺度超分辨成像研究, 主持, 部委级, 2018-01--2020-12
近期论文
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(1) DNA framework-based topological cell sorters, Angew. Chem. Int. Ed., 2020, 通讯作者
(2) DNA framework-mediated electrochemical biosensing platform for amplification-free microRNA analysis, Anal. Chem., 2020, 通讯作者
(3) A facile PEG/thiol-functionalized nanographene oxide carrier with an appropriate glutathioneresponsive switch, Polym. Chem., 2020, 通讯作者
(4) Genetically encoded X-ray cellular imaging for nanoscale protein localization, Natl. Sci. Rev., 2020, 通讯作者
(5) Classifying cell types with DNA-encoded ligand-receptor interactions on the cell membrane, Nano Lett., 2020, 通讯作者
(6) Blood exposure to graphene oxide may cause anaphylactic death in non-human primates, Nano Today, 2020, 通讯作者
(7) Framework Nucleic Acids as Programmable Carrier for Transdermal Drug Delivery, Nat. Commun., 2019, 第 2 作者
(8) DNA-Based Hybrid Hydrogels Sustain Water-Insoluble Ophthalmic Therapeutic Delivery against Allergic Conjunctivitis, ACS Appl. Mater. Interfaces, 2019, 通讯作者
(9) Theranostic Nanoplatform with Hydrogen Sulfide Activatable NIR Responsiveness for Imaging-Guided On-Demand Drug Release, Angew. Chem. Int. Ed., 2019, 通讯作者
(10) Hydrogen Sulfide-Activatable Second Near-Infrared Fluorescent Nanoassemblies for Targeted Photothermal Cancer Therapy, Nano Lett., 2018, 通讯作者
(11) Imaging of Colorectal Cancers Using Activatable Nanoprobes with Second Near-Infrared Window Emission, Angew. Chem. Int. Ed., 2018, 通讯作者
(12) Systematic Study in Mammalian Cells Showing No Adverse Response to Tetrahedral DNA Nanostructure, ACS Appl. Mater. Inter., 2018, 通讯作者
(13) Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors, Nat. Commun., 2018, 通讯作者
(14) Serum Protein Corona-Responsive Autophagy Tuning in Cells, Nanoscale, 2018, 通讯作者
(15) Enzyme-Triggered Fluorescence Turn-on: A Probe for Specifically Imaging Ovarian-Cancer-Related γ-Glutamyltranspeptidase, Chin. J. Chem., 2017, 第 3 作者
(16) Autophagy and lysosomal dysfunction: A New insight into the mechanism of synergistic pulmonary toxicity of carbon black-metal ions co-exposure, Carbon, 2017, 通讯作者
(17) Expression and radio-labeling of Cas9 protein, Nucl. Sci. Tech., 2017, 通讯作者
(18) Synchrotron-based X-ray microscopy for sub-100 nm resolution cell imaging, Curr. Opin. Chem. Biol., 2017, 第 1 作者
(19) Sodium alginate-functionalized nanodiamonds as sustained chemotherapeutic drug-release vectors, Carbon, 2016, 通讯作者
(20) One-shot immunomodulatory nanodiamond agents for cancer immunotherapy, Adv. Mater., 2016, 通讯作者
(21) Transportation and fate of gold nanoparticles in oilseed rape, RSC Adv., 2015, 通讯作者
(22) Fluorescent In Situ Targeting Probes for Rapid Imaging of Ovarian Cancer-Specific γ-Glutamyltranspeptidase, Angew. Chem. Int. Ed., 2015, 第 2 作者
(23) Culture medium-associated physicochemical insights on cytotoxicity of carbon nanomaterials, Chem. Res. Toxicol., 2015, 通讯作者
(24) Nanodiamonds act as Trojan horse for intracellular delivery of metal ions to trigger cytotoxicity, Part. Fibre Toxicol., 2015, 通讯作者
(25) Synchrotron-based X-ray microscopic studies for bioeffects of nanomaterials, Nanomedicine: NBM, 2014, 第 1 作者
(26) Synchrotron-based X-ray-sensitive Nanoprobes for Cellular Imaging, Adv. Mater., 2014, 第 1 作者
(27) Size-Dependent Cytotoxicity of Nanocarbon Blacks, Int. J. Mol. Sci. , 2013, 通讯作者
(28) Cytotoxicity of Phenol Red in Toxicity Assays for Carbon Nanoparticles, Int. J. Mol. Sci. , 2012, 第 1 作者
(29) The biocompatibility of nanodiamonds and their application in drug delivery systems, Theranostics, 2012, 第 1 作者
(30) Excessive Sodium Ions Delivered into Cells by Nanodiamonds: Implications for Tumor Therapy, Small, 2012, 第 1 作者
(31) Nanodiamonds as intracellular transporters of chemotherapeutic drug, Biomaterials, 2010, 第 1 作者
(32) Effects of serum proteins on intracellular uptake and cytotoxicity of carbon nanoparticles, Carbon, 2009, 第 1 作者
(33) Cytotoxicity of Carbon Nanotubes, Sci China Ser B, 2008, 第 1 作者
(34) The Interaction and Toxicity of Multi-Walled Carbon Nanotubes with Stylonychia Mytilus, J. Nanosci. Nanotechnol., 2006, 第 1 作者
(35) Dependence of the cytotoxicity of multi-walled carbon nanotubes on the culture medium, Nanotechnology, 2006, 第 1 作者