个人简介
招生专业
083100-生物医学工程
085238-生物工程
071010-生物化学与分子生物学
招生方向
类风湿关节炎,骨关节炎症的病机及治疗
骨组织工程
“老药新用”策略的转化型应用
教育背景
2005-09--2008-07 上海交通大学 博士
2002-09--2005-07 山东中医药大学 硕士
1997-09--2002-07 山东中医药大学 学士
工作简历
2013-11~现在, 中国科学院深圳先进技术研究院, 研究员
2011-08~2013-11,中国科学院深圳先进技术研究院, 副研究员
2010-03~2011-08,中国科学院深圳先进技术研究院, 助理研究员
2009-05~2010-03,香港中文大学, 研究助理
2008-07~2009-03,浙江大学, 博士后
教授课程
病理学与病理生理学
类风湿性关节炎
组织学
外科学
系统解剖学
奖励信息
(1) 科技管理工作先进工作者, 省级, 2018
(2) 全国卫生产业企业管理协会培训部专家, , 其他, 2011
(3) Who's Who in Medicine and Healthcare 收录, , 其他, 2011
(4) 国家自然科学基金评审专家, , 其他, 2011
(5) “国际病理科学与临床杂志”特约审稿人, , 其他, 2010
(6) “World journal of rheumatology”编委, , 其他, 2010
(7) “Pharmacologia” 编委, , 其他, 2010
(8) “Drugs and therapy studies”编委, , 其他, 2010
(9) Therapeutic Advances in Musculoskeletal Disease编委, , 其他, 2010
(10) “Annals of Internal Medicine” 优秀审稿人, , 其他, 2010
(11) 中国科学院深圳先进技术研究院先进工作者, , 研究所(学校), 2010
(12) 中国科学院深圳先进技术研究院2010年优秀员工, , 研究所(学校), 2010
(13) 第五届国际生物医学工程大会海报论文二等奖, 二等奖, 其他, 2010
(14) 中国组织工程研究与临床康复”第九届执行编委, , 其他, 2009
专利成果
( 1 ) 一种治疗类风湿性关节炎的药物组合物、制备方法及其贴剂, 实用新型, 2014, 第 1 作者, 专利号: 201410758729.5
( 2 ) 一种炎症伴发骨折复合疾病模型的制备方法, 实用新型, 2014, 第 1 作者, 专利号: 201410837178.1
( 3 ) 葫芦素E在制备治疗血管新生不足相关疾病 药物或生物医用材料中的用途和应用其的产品, 发明, 2018, 第 2 作者, 专利号: 201811013796 .9
( 4 ) 吡非尼酮在制备防治类风湿性关节炎的药物中的应用, 发明, 2019, 第 1 作者, 专利号: 201910917004.9
( 5 ) 吡非尼酮在制备促血管生成药物中的应用, 发明, 2019, 第 1 作者, 专利号: 201911287236.7
发表著作
(1) 实用关节镜手术学, Practice of arthroscopic surgery , 人民卫生出版社, 2009-10, 第 5 作者
(2) 转化医学理念、策略与实践, zhuanhuayixueliniancelvyushijian, 第四军医大学出版社, 2012-08, 第 4 作者
(3) 骨内科学, Gu Nei Ke Xue, 人民卫生出版社, 2013-07, 第 5 作者
(4) 美国骨矿研究学会骨矿盐疾病与代谢性骨病学, Primer on the metabolic bone diseases and disorders of mineral metabolism, 北京大学医学出版社, 2014-10, 第 5 作者
科研项目
( 1 ) 胆碱能受体激动剂GTS-21治疗类风湿性关节炎的实验研究, 主持, 国家级, 2011-01--2013-12
( 2 ) PLGA/TCP/icariin复合骨生物材料制备及生物性能评估, 参与, 省级, 2011-01--2012-12
( 3 ) 联合基因释放的增强TCP对长骨大段骨缺损修复研究, 参与, 省级, 2011-01--2013-12
( 4 ) 深圳市生物医疗电子与健康信息平台项目, 参与, 省级, 2011-01--2013-12
( 5 ) 中国科学院青年创新促进会, 主持, 部委级, 2012-01--2015-12
( 6 ) 类风湿性关节炎伴发骨折模型构建及愈合模式观察与机理研究, 主持, 国家级, 2013-01--2016-12
( 7 ) “蛋白质折叠码技术”在类风湿性关节炎治疗药物研发中的应用, 主持, 省级, 2014-08--2017-04
( 8 ) 应用“药物蛋白靶点指纹技术”探讨类风湿性关节炎治疗的“老药新用”策略, 主持, 省级, 2013-08--2015-07
( 9 ) 深圳医用生物活性材料工程实验室, 主持, 省级, 2012-10--2014-12
( 10 ) 类风湿关节炎模型的骨折愈合模式研究, 主持, 省级, 2014-12--2016-11
( 11 ) 深圳市孔雀技术创新, 主持, 省级, 2016-01--2017-12
( 12 ) 新型复合生物活性骨修复材料关键技术研发, 主持, 省级, 2016-01--2017-12
( 13 ) 葫芦素E经IL6/STAT3信号通路抗类风湿性关节炎的机制研究, 参与, 省级, 2017-02--2019-02
( 14 ) 祛风止痛胶囊对骨关节炎和骨质疏松疾病的疗效研究, 主持, 院级, 2015-12--2018-06
( 15 ) 基20170393 中药成分治疗类风湿性关节炎疗效和机制的研究, 主持, 省级, 2018-03--2021-03
( 16 ) 深圳医用生物活性材料工程研究中心提升, 主持, 省级, 2019-01--2021-12
( 17 ) 类风湿关节炎中医药治疗方案优化及循证评价研究, 参与, 国家级, 2018-12--2021-12
参与会议
(1)Study On The Therapeutic Effect Of Cucurbitacin E On Rheumatoid Arthritis And The Potential Mechanism 2020-09-25
(2)Study of genistein inhibit angiogenesis in rheumatoid arthritis via IL-6/JAK2/STAT3/VEGF signaling pathway 2018-09-24
(3)关于转化医学的个人探讨 北京市科委课题医学科研成果转化和应用的模式研究研讨会 张鹏 2012-05-03
(4)old drugs for new application: another new strategy for the treatment of rheumatoid arthritis 第一届国际免疫疾病治疗大会 Zhang P 2010-05-15
近期论文
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(1) Down-regulation of hypoxia-inducible factor-1α by RNA interference alleviates the development of collagen-induced arthritis in rats, Molecular Therapy-Nucleic Acids, 2020-01, 通讯作者
(2) Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway, Journal of Orthopaedic Translation, 2019-08, 通讯作者
(3) A 1064 nm excitable semiconducting polymer nanoparticle for photoacoustic imaging of gliomas, Nanoscale, 2019, 通讯作者
(4) Fracture Healing in a Collagen-Induced Arthritis Rat Model: Radiology and Histology Evidence, Journal of Orthopaedic Research, 2018, 通讯作者
(5) Relationship between heterotopic ossification and traumatic brain injury Why severe traumatic brain injury increases the risk of heterotopic ossification, Journal of Orthopaedic Translation, 2017, 通讯作者
(6) Study in Treatment of Collagen-Induced Arthritis in DBA/1 Mice Model by Genistein, Current Pharmaceutical Design, 2016, 通讯作者
(7) Cucurbitacin E inhibits TNF-α-induced inflammatory cytokine production in human synoviocyte MH7A cells via suppression of PI3K/Akt/NF-κB pathways., Int Immunopharmacol, 2015, 通讯作者
(8) GTS-21 attenuates lipopolysaccharide-induced inflammatory cytokine production in vitro by modulating the Akt and NF-κB signaling pathway through the α7 nicotinic acetylcholine receptor, Int Immunopharmacol, 2015, 通讯作者
(9) Attenuation of Collagen-Induced Arthritis in rat by nicotinic alpha7 receptor partial agonist GTS-21., Biomed Res Int., 2014, 通讯作者
(10) Genistein suppresses tumor necrosis factor α-induced inflammation via modulating reactive oxygen species/Akt/nuclear factor κB and adenosine monophosphate-activated protein kinase signal pathways in human synoviocyte MH7A cells., Drug Des Devel Ther., 2014, 通讯作者
(11) Genistein:the potential for efficacy in rheumatoid arthritis., Clinical Rheumatology, 2013, 通讯作者
(12) Advances in research on animal models of rheumatoid arthritis., Clinical rheumatology., 2013, 通讯作者
(13) Hypoxia-inducible factor: a potential therapeutic target for rheumatoid arthritis. , Curr Drug Targets., 2013, 通讯作者
(14) Hypoxia-Inducible Factor: A Potential Therapeutic Target for Rheumatoid Arthritis., Current Drug Targets, 2013, 通讯作者
(15) Berberine inhibits lipopolysaccharide and polyethylene particle-induced mouse calvarial osteolysis in vivo ., Journal of Surgery research., 2012, 通讯作者
(16) Effects of tetracyclines on bone: an ambiguous question needs to be clarified, Pharmazie, 2012, 通讯作者
(17) FGFReceptor-mediated Gene Delivery Using Ligands Coupled to PEI-?-CyD, Journal of Biomedicine and Biotechnology, 2012, 通讯作者
(18) 体外电化学测试对镁合金体内降解行为的预测, 化学进展, 2012, 第 3 作者
(19) Surface Modification of Magnesium Alloys Developed for Bioabsorbable Orthopaedic Implants: A General Review, Journal of Biomedical Materials Research Part B: Applied Biomaterials., 2012, 通讯作者
(20) 5-year Follow-up Study of A Kidney-tonifying Herbal Fufang for Prevention of Postmenopausal Osteoporosis and Fragility Fractures, Osteoporosis international ., 2012, 第 2 作者
(21) Bone marrow stromal cells with a combined expression of BMP-2 and VEGF-165 enhanced bone regeneration, Biomedical Materials, 2011, 第 4 作者
(22) Old drugs for new application: can orthopaedic research benefit from this strategy, Therapeutic Advances in Musculoskeletal Disease, 2011, 通讯作者
(23) Berberine inhibits lipopolysaccharide and polyethylene particle-induced mouse calvarial osteolysis in vivo, Journal of Surgery Research, 2011, 通讯作者
(24) Smoking and impaired bone healing: will activation5 of cholinergic anti-inflammatory pathway be the bridge, International Orthopaedics, 2011, 通讯作者
(25) 转化医学:基础医学与临床医学和实践的桥梁, 实用医学杂志(约稿述评), 2010, 通讯作者
(26) The potential application of nicotinic acetylcholine receptor agonists for the treatment of rheumatoid arthritis., Inflammation research, 2010, 通讯作者
(27) Traditional Chinese medicine in the treatment of rheumatoid arthritis: a general review., Rheumatology International, 2010, 通讯作者
(28) Old drugs” for the treatment of rheumatoid arthritis: will the cholinergic anti-inflammatory pathway and anti-nociceptive pathway work, Inflammation research, 2010, 通讯作者
(29) New therapeutic approaches for the treatment of rheumatoid arthritis may rise from the cholinergic anti-inflammatory pathway and anti-nociceptive pathway, ScientificWorldJournal, 2010, 通讯作者
(30) Hypoxia is essential for bone-tendon junction healing: the molecular biological evidence, International orthopaedics , 2010, 通讯作者
(31) The rheumatoid arthritis models and rheumatoid arthritis patients in clinics: How far is it between, Bone, 2010, 通讯作者
(32) Potential Use of Erythromycin to Prevent and Treat Prosthetic Failure, Journal of Clinical Pharmacolog, 2010, 通讯作者
(33) Integration of Traditional Chinese Medicine and modern medicine promotes the unification of human medicine, Journal of Medical Hypotheses and Ideas, 2010, 通讯作者
(34) The destruction evaluation in different foot joints------new ideas in collagen-induced arthritis rat model, Rheumatology International, 2009, 第 1 作者
(35) Effects of naringin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cell, European Journal of Pharmacology, 2009, 通讯作者
(36) Letter to Injection depth control for the treatment of Dupuytren‘s contracture using injectable collagenase clostridium histolyticum, New England Journal of Medicine , 2009, 通讯作者
(37) correspondence to Effectiveness of haemodialysis access with an autologous tissue-engineered vascular graft: a multicentre cohort study, Lancet , 2009, 通讯作者
(38) correspondence to Clinical transplantation of a tissue-engineered airway, Lancet , 2009, 通讯作者
(39) Osteoclast injection: a promising approach of cell therapy to obtain higher bone union ratio, Medical Hypothesis, 2009, 第 3 作者
(40) Promotion of Bone Formation by Naringin in a Titanium Particle-induced Diabetic Murine Calvarial Osteolysis Model, Journal of orthopedic research, 2009, 第 2 作者
(41) Tetracyclines Inhibit Rat Osteoclast Formation and Activity in vitro and Affect Bone Turnover in Young Rats in vivo, Calcified tissue international., 2009, 第 2 作者
(42) Inhibition of the development of Collagen-Induced Arthritis in wistar rats through Vagus Nerve Suspension: a 3-month observation, inflammation research , 2008, 第 1 作者
(43) Clinical roundup: How Do You Treat Chemical Sensitivity in Your Practice, Alternative and complementary therapies, 2008, 通讯作者
(44) A review of studies on the therapeutic effect of vagus nerve stimulation., Neural Regeneration Research, 2007, 第 1 作者