张蕾 - 中国科学院大学 - 生命科学学院

个人简介

教育背景 2000-09--2007-01 华中农业大学博士（硕博连读） 1996-09--2000-06 华中农业大学学士工作简历 2023-06~现在, 中国科学院海西研究院福建物质结构研究, 博士导师 2019-12~现在, 中国科学院海西研究院福建物质结构研究所, 研究员 2019-07~现在, 中国科学院大学, 硕士导师 2017-09~2018-09,美国圣约翰大学, 访问学者 2015-03~2019-12,中国科学院海西研究院福建物质结构研究所, 副研究员 2012-02~2015-02,中国科学院海西研究院福建物质结构研究所, 助理研究员 2010-09~2011-10,厦门大学, 科研助理 2007-08~2010-09,武汉大学, 博士后/讲师社会兼职 2020-07-01-今,福建农林大学生命科学技术学院研究生联合培养导师, 硕士研究生导师 2019-07-11-今,福建农林大学专业学位研究生校外专业实践导师,

研究领域

生化与分子生物学，包括肿瘤分子机理与抗肿瘤药物研究、多靶向抗肿瘤药物体系、新型口服疫苗机理等

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Jincan Chen, Yang Zhou, Meiru Song, Yijian Chen, Dong Wang, Yunmei Huang, Ping Hu, Chen He, Tao Dai, Lei Zhang, Mingdong Huang, Zhuo Chen, Peng Xu. A Serum-Stable supramolecular drug carrier for chemotherapeutics fabricated by a Peptide-Photosensitizer conjugate. JOURNAL OF COLLOID AND INTERFACE SCIENCE[J]. 2023, 646: 959-969, http://dx.doi.org/10.1016/j.jcis.2023.05.131. Ruikun Lin, Lei Zhang, Biwei Ye, Yanan Wang, YiDong Li, Hsu Jason, Wenzhen Liu, Ping Hu, Jincan Chen, ZheSheng Chen, Zhuo Chen. A multi-functional nano-system combining PI3K-110 alpha/Beta inhibitor overcomes P-glycoprotein mediated MDR and improves anti-cancer efficiency. CANCER LETTERS[J]. 2023, 563: http://dx.doi.org/10.1016/j.canlet.2023.216181. Zhang, Lei, Li, Yidong, Hu, Chaohua, Chen, Yangmin, Chen, Zhuo, Chen, ZheSheng, Zhang, JianYe, Fang, Shuo. CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells. MOLECULAR CANCER[J]. 2022, 21(1): http://dx.doi.org/10.1186/s12943-022-01524-w. Lei Zhang, Biwei Ye, Zhuo Chen, Zhe-Sheng Chen. Progress in the studies on the molecular mechanisms associated with multidrug resistance in cancers. ACTA PHARMACEUTICA SINICA. B[J]. 2022, 13(3): 982-997, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10031261/. Zhang, Lei, Ye, Biwei, Lin, Yunfeng, Li, YiDong, Wang, JingQuan, Chen, Zhuo, Ping, FengFeng, Chen, ZheSheng. Ribociclib Inhibits P-gp-Mediated Multidrug Resistance in Human Epidermoid Carcinoma Cells. FRONTIERS IN PHARMACOLOGY[J]. 2022, 13: http://dx.doi.org/10.3389/fphar.2022.867128. He, Chen, Zhang, Lei, Liu, Wenzhen, Huang, Yunmei, Hu, Ping, Dai, Tao, Xu, Jianhua, Chen, Zhuo. Albumin-based nanoparticles combined with photodynamic therapy enhance the antitumor activity of curcumin derivative C086. DYES AND PIGMENTS[J]. 2021, 189: http://dx.doi.org/10.1016/j.dyepig.2021.109258. Zhang, Lei, Li, Zhen, Ye, Xianren, Chen, Zhuo, Chen, ZheSheng. Mechanisms of thrombosis and research progress on targeted antithrombotic drugs. DRUG DISCOVERY TODAY[J]. 2021, 26(10): 2282-2302, http://dx.doi.org/10.1016/j.drudis.2021.04.023. Lin, Yunfeng, Chen, Zhuo, Hu, Chaohua, Chen, ZheSheng, Zhang, Lei. Recent progress in antitumor functions of the intracellular antibodies. DRUG DISCOVERY TODAY[J]. 2020, 25(6): 1109-1120, http://dx.doi.org/10.1016/j.drudis.2020.02.009. Tao Dai et al.. A strategy for enhanced tumor targeting of photodynamic therapy based on Escherichia coli-driven drug delivery system一种基于大肠杆菌驱动药物递送系统增强光动力治疗的肿瘤靶向策略. Science China-Materials[J]. 2020, [10] Liu, Jihao, Chen, Zhuo, Huang, Mingdong, Tang, Shuzhi, Wang, Qianchao, Hu, Ping, Gupta, Pranav, Ashby, Charles R, Chen, ZheSheng, Zhang, Lei. Plasminogen activator inhibitor (PAI) trap3, an exocellular peptide inhibitor of PAI-1, attenuates the rearrangement of F-actin and migration of cancer cells. EXPERIMENTAL CELL RESEARCH[J]. 2020, 391(1): http://dx.doi.org/10.1016/j.yexcr.2020.111987. Zhang Lei, Chen Zhuo. Research Progress of Structure Based Antitumor Drug Design. CHINESE JOURNAL OF STRUCTURAL CHEMISTRY[J]. 2020, 39(12): 2085-2090, http://lib.cqvip.com/Qikan/Article/Detail?id=7103737695. Lei Zhang, Yidong Li, Qianchao Wang, Zhuo Chen, Xiaoyun Li, Zhuoxun Wu, Chaohua Hu, Dan Liao, Wei Zhang, ZheSheng Chen. The PI3K subunits, P110α and P110β are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer. MOLECULAR CANCER[J]. 2020, 19(1): 1-18, http://dx.doi.org/10.1186/s12943-019-1112-1. Sun, Jing, Zhang, Yuxiang, Su, Jianqiang, Dai, Tao, Chen, Jincan, Zhang, Lei, Wang, Huanhuan, Liu, Wenzhen, Huang, Mingdong, Chen, Zhuo. Naftifine enhances photodynamic therapy against Staphylococcus aureus by inhibiting staphyloxanthin expression. DYES AND PIGMENTS[J]. 2020, 179: http://dx.doi.org/10.1016/j.dyepig.2020.108392. Liao, Dan, Zhang, Wei, Gupta, Pranav, Lei, ZiNing, Wang, JingQuan, Cai, ChaoYun, De Vera, Albert A, Zhang, Lei, Chen, ZheSheng, Yang, DongHua. Tetrandrine Interaction with ABCB1 Reverses Multidrug Resistance in Cancer Cells Through Competition with Anti-Cancer Drugs Followed by Downregulation of ABCB1 Expression. MOLECULES[J]. 2019, 24(23): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000507294400182. Zhang L, Yang W, Hu C, Wang Q, Wu Y. Properties and applications of nanoparticle/microparticle conveyors with adjuvant characteristics suitable for oral vaccination. INTERNATIONAL JOURNAL OF NANOMEDICINE[J]. 2018, 13: 2973-2987, https://doaj.org/article/a30f57c93c8b4b339602fd0e44cca3a0. Zhang, Lei, Zeng, Zhanzhuang, Hu, Chaohua, Bellis, Susan L, Yang, Wendi, Su, Yintao, Zhang, Xinyan, Wu, Yunkun. Controlled and targeted release of antigens by intelligent shell for improving applicability of oral vaccines. BIOMATERIALS[J]. 2016, 77: 307-319, http://dx.doi.org/10.1016/j.biomaterials.2015.11.009. 胡朝华, 张蕾, 张又弛, 万顺刚. 非均相高效催化剂在餐厨废油转化生物柴油中的应用. 环境工程[J]. 2016, 34(9): 105-109, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=5803237&detailType=1. Zhang, Lei, Hu, Chaohua, Yang, Wendi, Liu, Xiaolin, Wu, Yunkun. Chemical Synthesis, Versatile Structures and Functions of Tailorable Adjuvants for Optimizing Oral Vaccination. ACS APPLIED MATERIALS & INTERFACESnull. 2016, 8(51): 34933-34950, https://www.webofscience.com/wos/woscc/full-record/WOS:000391081700001. 苏银桃, Fangyuan Shi, 曾占壮, 吴秀玲, Yanhe Zhao, Lei Zhang, 谢佐福, Wu Yunkun. A Versatile Monoclonal Antibody Specific Against Human DAB2IP.. Monoclon Antib Immunodiagn Immunother.[J]. 2015, [20] Zhang, Lei, Bellis, Susan L, Fan, Yiwen, Wu, Yunkun. Using inositol as a biocompatible ligand for efficient transgene expression. INTERNATIONAL JOURNAL OF NANOMEDICINE[J]. 2015, 10: 2871-2884, https://www.webofscience.com/wos/woscc/full-record/WOS:000352772200001. Zhang, Lei, Fan, Yiwen, Wu, Yunkun. Inositol based non-viral vectors for transgene expression in human cervical carcinoma and hepatoma cell lines. BIOMATERIALS[J]. 2014, 35(6): 2039-2050, http://dx.doi.org/10.1016/j.biomaterials.2013.11.034. Zhang, Lei, Hu, Chaohua, Fan, Yiwen, Wu, Yunkun. Binary gene vectors based on hyperbranched poly( L-lactide-co-polyglycerol) and polyethylenimine for prolonged transgene expression via co-assembly with DNA into fiber core-shell triplexes. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2013, 1(45): 6271-6282, https://www.webofscience.com/wos/woscc/full-record/WOS:000326648800010. Zhang, Lei, Hu, ChaoHua, Cheng, SiXue, Zhuo, RenXi. Hyperbranched amphiphilic polymer with folate mediated targeting property. COLLOIDS AND SURFACES B-BIOINTERFACES[J]. 2010, 79(2): 427-433, http://dx.doi.org/10.1016/j.colsurfb.2010.05.014. Zhang, Lei, Hu, ChaoHua, Cheng, SiXue, Zhuo, RenXi. PEI grafted hyperbranched polymers with polyglycerol as a core for gene delivery. COLLOIDS AND SURFACES B-BIOINTERFACES[J]. 2010, 76(2): 427-433, http://dx.doi.org/10.1016/j.colsurfb.2009.12.001. Hu, ChaoHua, Zhang, Lei, Wu, DeQun, Cheng, SiXue, Zhang, XianZheng, Zhuo, RenXi. Heparin-modified PEI encapsulated in thermosensitive hydrogels for efficient gene delivery and expression. JOURNAL OF MATERIALS CHEMISTRY[J]. 2009, 19(20): 3189-3197, http://dx.doi.org/10.1039/b817956e. Zhang, L, Hu, C, Ye, W, Zhu, D, Yu, Z, Zhuo, R, Sun, M. The copper-resistant bacterium ACU isolated from the rhizosphere of Eichhornia crassipes (Mart.) increased the endurance of Potamogeton crispus L. to copper toxicity. JOURNAL OF APPLIED MICROBIOLOGY[J]. 2008, 105(4): 1034-1043, https://www.webofscience.com/wos/woscc/full-record/WOS:000259270500012. Zhang, Lei, Ruan, Lifang, Hu, Chaohua, Wu, Huaiguang, Chen, Shouwen, Yu, Ziniu, Sun, Ming. Fusion of the genes for AHL-lactonase and S-layer protein in Bacillus thuringiensis increases its ability to inhibit soft rot caused by Erwinia carotovora. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2007, 74(3): 667-675, https://www.webofscience.com/wos/woscc/full-record/WOS:000244300100020. Hu, Chaohua, Zhang, Lei, Hamilton, David, Zhou, Wenbing, Yang, Tewu, Zhu, Duanwei. Physiological responses induced by copper bioaccumulation in Eichhornia crassipes (Mart.). HYDROBIOLOGIA[J]. 2007, 579: 211-218, https://www.webofscience.com/wos/woscc/full-record/WOS:000244187200017.