个人简介
招生专业
071005-微生物学
工作经历
2020年5月至今：中国科学院分子植物科学卓越创新中心（植物生理生态研究所）
2004-12~2020-4, 上海生命科学研究院, 研究员
2003-05~2004-11,上海交通大学, 副教授
2000-04~2003-03,日本东京大学, 外国人研究员
教授课程
合成生物学与系统生物学
科研项目
（ 1 ） ‘新功能人造生物器件的构建与集成’之课题三‘新功能人造生物器件的构建’, 主持, 国家级, 2012-01--2016-12
（ 2 ） 乙酰化修饰在里氏木霉纤维素酶合成调控中的功能研究, 主持, 国家级, 2015-01--2018-12
（ 3 ） 稀有人参皂苷生物合成中重要生物元件及人工合成体系的设计、组装与适配, 主持, 省级, 2014-07--2017-06
（ 4 ） 微生物发酵生产人参皂苷CK技术, 主持, 院级, 2015-04--2018-04
（ 5 ） 木质纤维素酶研究和产业化, 主持, 院级, 2015-12--2018-12
（ 6 ） 高品质稀有人参皂苷CK的制备及合成生物学关键技术研究, 主持, 国家级, 2017-01--2020-12
（ 7 ） 高效合成人参皂苷CK的酵母细胞工厂的研究, 主持, 国家级, 2017-01--2018-12
（ 8 ） 人参皂苷的细胞工厂合成关键技术研发及范, 主持, 部委级, 2016-01--2017-12
（ 9 ） 面向天然产物生物合成的人工细胞, 参与, 部委级, 2018-01--2022-12
（ 10 ） 合成非天然基因组生产植物天然产物, 主持, 部委级, 2018-01--2019-12
（ 11 ） 微生物发酵生产人参皂苷CK, 主持, 研究所（学校）, 2015-01--2020-12
（ 12 ） 木质纤维素酶研究和产业化, 主持, 研究所（学校）, 2016-01--2019-06
近期论文
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1. Yu Ping#, Xiaodong Li#, Baofu Xu, Wei Wei, Wenping Wei, Guoyin Kai, ZhiHua Zhou*, and Youli Xiao*, Building Microbial Hosts for Heterologous Production of N-methylpyrrolinium, ACS Synthetic Biology，2019，DOI: 10.1021/acssynbio.8b00483 通讯作者
2. Yu Ping#, Xiaodong Li#, Wenjing You#, Guoqiang Li#, Mengquan Yang, Wenping Wei, ZhiHua Zhou*, and Youli Xiao*, De Novo Production of the Plant-Derived Tropine and Pseudotropine in Yeast, ACS Synthetic Biology, 2019, doi: 10.1021/acssynbio.9b00152.通讯作者
3. Pingping Wang, Wei Wei, Wei Ye, Xiaodong Li, Wenfang Zhao, Chengshuai Yang, Chaojing Li, Xing Yan*, Zhihua Zhou*. Synthesizing ginsenoside Rh2 in Saccharomyces cerevisiae cell factory at high-efficiency, Cell Discovery, 2019, 5 (5): 1-14通讯作者
4. Gen Zou, Yanping Jiang, Rui Liu, Zhihua Zhu, Zhihua Zhou*, The putative β-glucosidase BGL3I regulates cellulase induction in Trichoderma reesei. Biotechnology for Biofuels (2018) 11:314;通讯作者
5. Chengshuai Yang, Weichao Li, Chen Li, Zhihua Zhoua∗, Youli Xiaoa∗, Xing Yana∗. Metabolism of ganoderic acids by a Ganoderma lucidum cytochrome P450 and the 3-keto sterol reductase ERG27 from yeast. Phytochemistry (2018) 155:83-92通讯作者
6. 王平平、杨成帅、李晓东、蒋雨果、严兴、周志华*， 植物天然化合物的人工合成之路. 有机化学 (Chinese Journal of Organic Chemistry) （SCI）. 2018. 38：2199-2214通讯作者
7. A novel transcription factor specifically regulates GH11 xylanase genes in Trichoderma reesei, Biotechnol Biofuels, 2017, 通讯作者
8. Lysine acetylation regulates the function of the global anaerobic transcription factor FnrL in Rhodobacter sphaeroides: Acetylation of FnrL in Rhodobacter sphaeroides, Molecular Microbiology, 2017, 通讯作者
9. Characterization of the Ca2+-responsive signaling pathway in regulating the expression and secretion of cellulases in Trichoderma reesei Rut-C30, Molecular Microbiology, 2016, 通讯作者
10. RNA Sequencing Reveals Xyr1 as a Transcription Factor Regulating Gene Expression beyond Carbohydrate Metabolism., Biomed Res Int., 2016, 通讯作者
11. Insight into Dominant Cellulolytic Bacteria from Two Biogas Digesters and Their Glycoside Hydrolase Genes, PLoS One, 2015, 通讯作者
12. Characterizations of Panax ginseng UDP-glycosyltransferases catalyzing protopanaxatriol and biosyntheses of bioactive ginsenosides F1 and Rh1 in metabolically engineered yeasts, Molecular Plant, 2015, 通讯作者
13. Production of bioactive ginsenosides Rh2 and Rg3 by metabolically engineered yeasts, Metab Eng, 2015, 通讯作者
14. Efficient genome editing in filamentous fungus Trichoderma reesei using the CRISPR/Cas9 system, Cell Discovery, 2015, 通讯作者
15. Production of bioactive ginsenoside compound K in metabolically engineered yeast, Cell Research, 2014, 通讯作者
16. Engineering a high-performance, metagenomic-derived novel xylanase with improved soluble protein yield and thermostability, Enzyme and Microbial Technology, 2014, 通讯作者
17. The distinctive regulatory roles of PrtT in the cell metabolism of Penicillium oxalicum, Fungal Genet Biol, 2014, 通讯作者
18. Function of glucose catabolic pathways in hydrogen production from glucose in Rhodobacter sphaeroides 6016, International Journal of Hydrogen Energy, 2014, 通讯作者
19. N-Glycosylation Affects the Proper Folding, Enzymatic Characteristics and Production of a Fungal β-Glucosidase, Biotechnol Bioeng, 2013, 通讯作者
20. Biochemical Characterization and Crystal Structure of a GH10 Xylanase from Termite Gut Bacteria Reveal a Novel Structural Feature and Significance of Its Bacterial Ig-like Domain, Biotechnol Bioeng, 2013, 通讯作者
21. Metagenomic insights into metabolic capacities of the gut microbiota in a fungus-cultivating termite, PLoS One, 2013, 通讯作者
22. Discovery of (hemi-)cellulase genes in a metagenomic library from a biogas digester using 454 pyro-sequencing, Applied Microbiology and Biotechnology, 2013, 通讯作者
23. Long-term strain improvements accumulate mutations in regulatory elements responsible for hyper-production of cellulolytic enzymes, Sci. Rep., 2013, 通讯作者
24. Genomic and Secretomic Analyses Reveal Unique Features of the Lignocellulolytic Enzyme System of Penicillium decumbens, PLoS ONE, 2013, 通讯作者
25. Blocking the butyrate-formation pathway impairs hydrogen production in Clostridium perfringens, Acta Biochim Biophys Sin., 2013, 通讯作者
26. Characterization of a novel thermostable -glucosidase from a metagenomic library of termite gut, Enzyme and Microbial Technology, 2012, 通讯作者
27. Construction of a cellulase hyper-expression system in Trichoderma reesei by promoter and enzyme engineering, Microbial Cell Factories, 2012, 通讯作者
28. Expression and characterization of a novel metagenome-derived cellulase Exo2b and its application to improve cellulase activity in Trichoderma reesei, Applied Microbiology and Biotechnology, 2012, 通讯作者
29. Improvement of cellulase activity in Trichoderma reesei by heterologous expression of a beta-glucosidase gene from Penicillium decumbens, Enzyme and Microbial Technology, 2011, 通讯作者
30. Microbiome of fungus-growing termites: a new reservoir for mining lignocellulase genes,, Applied and Environmental Microbiology, 2011, 通讯作者
31. Improvement of Hydrogen Yield By Hupr Gene Knock-Out And Nifa Gene Overexpression In Rhodobacter Sphaeroides 6016., International Journal of Hydrogen Energy, 2010, 通讯作者
32. Succession of the Bacterial Community and Dynamics of Hydrogen Producers in a Hydrogen-Producing Bioreactor., Applied and Environmental Microbiology, 2010, 通讯作者
33. Derepressive Effect of NH4+ on Hydrogen Production by Deleting the glnA1 Gene in Rhodobacter sphaeroides., Biotechnology and Bioengineering, 2010, 通讯作者
34. Statistical optimization of process parameters on biohydrogen production from sucrose by co-culture of Clostridium acidisoli sp. Nov and Rhodobacter sphaeroides., International Journal of Hydrogen Energy, 2010, 通讯作者
35. Effect of Key Factors on Hydrogen Production from Cellulose in a Co-Culture of Clostridium thermocellum and C. thermopalmarium., Bioresource Technology, 2010, 通讯作者
36. Efficient hydrogen gas production from cassava and food waste by a two-step process of dark fermentation and photo-fermentation., Biomass and Bioenergy, 2009, 通讯作者
37. The structure of the bacterial and archaeal community in a biogas digester as revealed by denaturing gradient gel electrophoresis and 16S rDNA sequencing analysis., Journal of Applied Microbiology, 2009, 通讯作者
38. Characteristics of a new photosynthetic bacterial strain for hydrogen production and its application in wastewater treatment., International Journal of Hydrogen Energy, 2008, 通讯作者
39. High hydrogen yield from a two-step process of dark- and photo-fermentation of sucrose., International Journal of Hydrogen Energy, 2007, 通讯作者
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