个人简介

B.S. 1998, Kyung Hee University (Seoul, Korea) M.S. 2000, KAIST (Taejon, Korea) Ph.D. 2004, Northwestern University (Evanston, IL) Postdoctoral Research Fellow 2004-2007, The Scrrips Research Institute AWARDS & HONORS NIH Director’s New Innovator Award (2009~2014) Burroughs Wellcome Fund Collaborative Research Grant (2014~2015) Early Career Investigator Travel Fellowship, Nanotechnologies in Cancer at Memorial Sloan-Kettering Cancer Center (2013) Bush Biomedical Grant Award (2013~2014) New Jersey Spinal Cord Exploratory Research Award (2013~2015) Board of Trustees Research Award for Scholarly Excellence (2013) Faculty Research Award, Rutgers University (2012~2013) Johnson and Johnson Proof-of-Concept Award (2011~2012) New Jersey Spinal Cord Research Award (2009~2013) Grant Proposal Development Award, Rutgers University (2008) CIRM (California Institute for Regenerative Medicine) Post-doctoral Fellowship (2006~2007) NSEC (Nanoscale Science and Engineering Center) Outstanding Research Award, Northwestern University (2004) MRS (Materials Research Society) Graduate Student Award (2003) Korean-American Scholarship (2003) L. Carroll King Award for Excellence Chemistry Teaching, Northwestern University (2001) University Presidential Fellowship, Northwestern University (2001) Honor scholarship, Kyung Hee University (95-97) NSEC Board of Student Advisors (2000-2004)

研究领域

Analytical Chemistry/Biophysical Chemistry/Materials Chemistry/Organic Chemistry

Develop and integrate nanotechnologies and chemical functional genomics The primary research interest of our group is to develop and integrate nanotechnology and chemical biology to modulate signaling pathways in cancer and stem cells. More specifically, our research focuses on identifying the various microenvironmental cues (e.g. soluble signals, cell-cell interactions, and insoluble/physical signals) affecting stem cell and cancer cell fate and thereafter utilizing these cues for the neuro-differentiation of stem cells and apoptosis of brain tumor cells. Our group is creating new tools to better understand the roles of individual microenvironmental cues in cancer and stem cell behaviors. We are also developing novel platforms to deliver biomolecules and to control the signaling elements inside cells in a spatiotemporally controlled manner. Taken together, our work helps to lay the groundwork for the rational step-by-step emulation of cellular microenvironments using nanomaterials. We are also working towards the novel design of several nanomaterials and 3D-ECM platforms which can be responsive to external signals (e.g. light, pH, and enzymes), while leveraging our expertise to expand into several new directions. Among its nearly 15 members, our group spans many disciplines—organic, inorganic, and physical chemistry; pharmaceutical sciences; chemical and biomedical engineering; and molecular and stem cell biology.

近期论文

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Patel, S.; Pongkulapa, T.; Yin, P.T.; Pandian, G; Rathnam, C.; Bando, T.; Vaijayanthi, T.; Sugiyama, H.†; Lee, K.-B.†, "Integrating Epigenetic Modulators into NanoScript for Enhanced Chondrogenesis of Stem Cells", J. Am.Chem. Soc., 2015, In Press Yin, P.T.; Shah, S.; Chhowalla, M.; Lee, K.-B.†, "Design, Synthesis, and Characterization of Graphene-Nanoparticle Hybrid Materials for Bio-applications", Chemical Reviews, 2015, In Press Yin, P.T.; Han, E.; Lee, K.-B.†, "Engineering Stem Cells for Biomedical Applications", Advanced Healthcare Materials, 2015, In Press Patel,S.; Lee, K.-B.†, "Probing Stem Cell Behavior using Nanoparticle-based Approaches", WIREs Nanomedicine & Nanobiotechnology, 2015, In Press Yin, P. T., Kim, T.-H., Choi, J.-W. and Lee, K.-B., "High-Throughput Screening of Stem Cell Self-Renewal and Differentiation on Nanomaterials", Stem-Cell Nanoengineering, 2015, DOI: 10.1002/9781118540640.ch19 Lai, J.; Zhang, Y.; Pasquale, N.; Lee, K.-B.†, "An Upconversion Nanoparticle with Orthogonal Emissions using Dual NIR Excitations for Controlled Two-way Photoswitching", Angew. Chem. Int. Ed., 2014, 53, 14419-14423 Shah, S.; Sasmal, P.; Lee, K.-B.†, "Photo-triggerable hydrogel–nanoparticle hybrid scaffolds for remotely controlled drug delivery", Journal of Materials Chemistry B, 2014, 2, 7685-7693 Royce, S.G.; Mukherjee D.; Cai T.; Xu S.S.; Alexander J.A.; Mi Z., Calderon L.; Mainelis G.; Lee, K.-B. Lioy P.J.; Tetley T.D.; Chung K.F.; Zhang J.; Georgopoulos P.G., "Modeling population exposures to silver nanoparticles present in consumer products", Journal of Nanoparticle Research, 2014, 16, 27724 Patel, S.; Jung, D.; Yin, P.T.; Carlton, P.; Yamamoto, M.; Bando, T.; Sugiyama, H.; Lee, K.-B.†, "NanoScript: A Nanoparticle-Based Artificial Transcription Factor for Effective Gene Regulation", ACS Nano, 2014, 9, 8959-8967 Shah, B. P.; Pasquale, N.; De, G.; Tan, T.; Ma, J.; Lee, K.-B.†, "Core-Shell Nanoparticle-Based Peptide Therapeutics and Combined Hyperthermia for Enhanced Cancer Cell Apoptosis", ACS Nano, 2014, 9, 9379-9387 Yin, P. T., Kim, T.-H., Choi, J.-W. and Lee, K.-B., "Chemical and Biosensors Based on Graphene Materials", Graphene Optoelectronics, 2014, DOI: 10.1002/9783527677788.ch10 Kim, T.-H.; Cho, H.-Y.; Lee, K.-B.; Kim, S.U.; Choi, J.-W.†, "Electrically-Controlled Delivery of Cargo into Single Human Neural Stem Cell", ACS Applied Materials & Interfaces, 2014, 6, 20709-20716 Yin, P.T.; Shah, B. P.; Lee, K.-B.†, "Combined magnetic nanoparticle-based microRNA and hyperthermia therapy to enhance apoptosis in brain cancer cells", Small, 2014, 20, 4106-4112 Shah, S.; Yin, PT.; Uehara, T.M.; Chueng, ST.D.; Yang, L.; Lee, K.-B.†, "Guiding Stem Cell Differentiation into Oligodendrocytes Using Graphene-Nanofiber Hybrid Scaffolds", Advanced Materials, 2014, 26, 3673–3680. Inside Front Cover Sarkar, S.; Zhang, L.; Subramaniam, P.; Lee, K.-B.; Garfunkel, E.; Ohman Strickland, P.A.; Mainelis, G.; Lioy, P. J.; Tetley, T.; Chung, K.F.; Zhang, J.; Schwander, S.†, "Variability in Bioreactivity Linked to Changes in Size and Zeta Potential of Diesel Exhaust Particles in Human Immune Cells", PLOS ONE, 2014 , May, 9, e97304. Shah, S.*; Solanki A.*; Sasmal, P.; Lee, K.-B.†, "Single Vehicular Delivery of siRNA and Small Molecules to Control Stem Cell Differentiation", J. Am. Chem. Soc., 2013, 135, 15682-15685. Kim, T.-H.; Lee, K.-B.; Choi, J.-W.†, "3D Graphene Oxide-encapsulated Gold Nanoparticles to Detect Neural Stem Cell Differentiation", Biomaterials, 2013, 34, 8660-8670. Solanki, A.; Chueng, ST.D.; Yin, PT.; Kappera, R.; Chhowalla, M.; Lee, K.-B.†, "Axonal Alignment and Enhanced Neuronal Differentiation of Neural Stem Cells on Graphene-Nanoparticle Hybrid Structures", Advanced Materials, 2013, 25, 5477-5482. Frontispiece Yin, P.T.; Kim, T.-H.; Choi,J. -W.; Lee, K.-B.†, "Prospects for Graphene-Nanoparticle-Based Hybrid Sensors", Phys. Chem. Chem. Phys., 2013, 15, 12785-12799, 12785-12799. Shah, B.P.; Yin, PT.; Ghoshal, S.; Lee, K.-B.†, "Multimodal Magnetic Core–Shell Nanoparticles for Effective Stem-Cell Differentiation and Imaging", Angewandte Chemie, 2013, 52, 6190-6195