McFadden, Geoffrey - University of Melbourne

研究领域

Origin of mitochondria Origin of plastids Parasitology, Endosymbiosis, Molecular Evolution. (Malaria, Chloroplasts,drugs)

近期论文

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Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase. PLoS Pathogens. 12. 2016 Characterization of the Plasmodium falciparum and P. berghei glycerol 3-phosphate acyltransferase involved in FASII fatty acid utilization in the malaria parasite apicoplast. Cellular Microbiology. 2016 Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes. Science. 352. 2016 Targeting of a transporter to the outer apicoplast membrane in the human malaria parasite Plasmodium falciparum. PLoS One. 11. 2016 The Plasmodium translocon of exported proteins component EXP2 is critical for establishing a patent malaria infection in mice. Cellular Microbiology. 18. 2016 A serine-arginine-rich (SR) splicing factor modulates alternative splicing of over a thousand genes in Toxoplasma gondii. Nucleic Acids Research. 43. 2015 Endosymbiosis undone by stepwise elimination of the plastid in a parasitic dinoflagellate. Proceedings of the National Academy of Sciences of the United States of America. 112. 2015 Fatty acid metabolism in the Plasmodium apicoplast: Drugs, doubts and knockouts. Molecular and Biochemical Parasitology. 199. 2015 Macrolides rapidly inhibit red blood cell invasion by the human malaria parasite, Plasmodium falciparum. BMC Biology. 13. 2015 Mitochondrial ATP synthase is dispensable in blood-stage Plasmodium berghei rodent malaria but essential in the mosquito phase. Proceedings of the National Academy of Sciences of the United States of America. 112. 2015 Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites. Blood. 125. 2015