Pauli, Guido Frank - The University of Illinois at Chicago

个人简介

A pharmacist by training with specialization in pharmaceutical analysis, he holds a doctoral degree (Dr. rer. nat.) in pharmacognosy. Dr. Pauli is a Professor and University Scholar in the College of Pharmacy at the University of Illinois at Chicago. He is PI and collaborator in NIH-funded interdisciplinary and translational projects involving bioactive natural products, including Technology and Botanical Research Centers. Main research interests involve the metabolomic analysis of natural health products, botanicals, anti-TB drug discovery, and dental biomodifiers. Contributing his key expertise in the development of analytical methodology and innovative approaches, Dr. Pauli seeks to address challenges posed by nature's metabolomic variation and complexity. His academic track record includes mentoring of 17 Ph.D. students, 14 postdoctoral scientist, 7 visiting professors, and active international collaborations particularly in China and Europe. His publication portfolio comprises 150+ peer-reviewed journal articles and an h-index of 34 (Scopus).

近期论文

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Simmler C, Graham JG, Chen S, Pauli GF. Integrated analytical assets aid botanical authenticity and adulteration management.. Fitoterapia. 2018;129:401-414. doi:10.1016/j.fitote.2017.11.017. McAlpine JB, Chen S, Kutateladze A, MacMillan JB, Appendino G, Barison A, Beniddir MA, Biavatti MW, Bluml S, Boufridi A, Butler MS, Capon RJ, Choi YH, Coppage D, Crews P, Crimmins MT, Csete M, Dewapriya P, Egan JM, Garson MJ, Genta-Jouve G, Gerwick WH, Gross H, Harper MK, Hermanto P, Hook JM, Hunter L, Jeannerat D, Ji NY, Johnson TA, Kingston DGI , Koshino H, Lee HW, Lewin G, Li J, Linington RG, Liu M, McPhail KL, Molinski TF, Moore BS, Nam J, Neupane RP, Niemitz M, Nuzillard JM, Oberlies NH, Ocampos FMM , Pan G, Quinn RJ, Reddy DS, Renault JH, Rivera-Chávez J, Robien W, Saunders CM, Schmidt TJ, Seger C, Shen B, Steinbeck C, Stuppner H, Sturm S, Taglialatela-Scafati O, Tantillo DJ, Verpoorte R, Wang BG, Williams CM, Williams PG, Wist J, Yue JM, Zhang C, Xu Z, Simmler C, Lankin DC, Bisson J, Pauli GF. The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research.. Natural Product Reports. 2018;. doi:10.1039/c7np00064b. Choules MP, Klein L, Lankin DC, McAlpine JB, Cho S, Cheng J, Lee H, Suh JW, Jaki BU, Franzblau SG, Pauli GF. Residual Complexity Does Impact Organic Chemistry and Drug Discovery: The Case of Rufomyazine and Rufomycin.. The Journal of organic chemistry. 2018;83(12):6664-6672. doi:10.1021/acs.joc.8b00988. Fan Q, Liu Y, Kulakowski D, Chen S, Friesen JB, Pauli GF, Song Q. Countercurrent separation assisted identification of two mammalian steroid hormones in Vitex negundo.. Journal of chromatography. A. 2018;1553:108-115. doi:10.1016/j.chroma.2018.04.033. Liu Y, Zhang Y, Chen S, Friesen JB, Nikolić D, Choules MP, McAlpine JB, Lankin DC, Gemeinhart RA, Pauli GF. The influence of natural deep eutectic solvents on bioactive natural products: studying interactions between a hydrogel model and Schisandra chinensis metabolites.. Fitoterapia. 2018;127:212-219. doi:10.1016/j.fitote.2018.02.024. Hajirahimkhan A, Mbachu OC, Simmler C, Ellis SG, Dong H, Nikolic DS, Lankin DC, van Breemen RB, Chen S, Pauli GF, Dietz BM, Bolton JL. Estrogen Receptor (ER) Subtype Selectivity Identifies 8-Prenylapigenin as an ERβ Agonist from Glycyrrhiza inflata and Highlights the Importance of Chemical and Biological Authentication.. Journal of natural products. 2018;81(4):966-975. doi:10.1021/acs.jnatprod.7b01070. Liu Y, Friesen JB, McAlpine JB, Lankin DC, Chen S, Pauli GF. Natural Deep Eutectic Solvents: Properties, Applications, and Perspectives.. Journal of natural products. 2018;81(3):679-690. doi:10.1021/acs.jnatprod.7b00945. Allard PM, Bisson J, Azzollini A, Pauli GF, Cordell GA, Wolfender JL. Pharmacognosy in the digital era: shifting to contextualized metabolomics.. Current opinion in biotechnology. 2018;54:57-64. doi:10.1016/j.copbio.2018.02.010. Phansalkar RS, Nam J, Chen S, McAlpine JB, Leme AA, Aydin B, Bedran-Russo AK, Pauli GF. Centrifugal partition chromatography enables selective enrichment of trimeric and tetrameric proanthocyanidins for biomaterial development.. Journal of chromatography. A. 2018;1535:55-62. doi:10.1016/j.chroma.2017.12.050. Dunlap TL, Howell C, Mukand N, Chen S, Pauli GF, Dietz BM, Bolton JL. Red Clover Aryl Hydrocarbon Receptor (AhR) and Estrogen Receptor (ER) Agonists Enhance Genotoxic Estrogen Metabolism.. Chemical research in toxicology. 2017;30(11):2084-2092. doi:10.1021/acs.chemrestox.7b00237. Li G, Simmler C, Chen L, Nikolic DS, Chen S, Pauli GF, van Breemen RB. Cytochrome P450 inhibition by three licorice species and fourteen licorice constituents.. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2017;109:182-190. doi:10.1016/j.ejps.2017.07.034. Keiler AM, Macejova D, Dietz BM, Bolton JL, Pauli GF, Chen S, van Breemen RB, Nikolic DS, Goerl F, Muders MH, Zierau O, Vollmer G. Evaluation of estrogenic potency of a standardized hops extract on mammary gland biology and on MNU-induced mammary tumor growth in rats.. The Journal of steroid biochemistry and molecular biology. 2017;174:234-241. doi:10.1016/j.jsbmb.2017.09.020. Gao W, McAlpine JB, Choules MP, Napolitano JG, Lankin DC, Simmler C, Ho NA, Lee H, Suh JW, Burton IW, Cho S, Franzblau SG, Chen S, Pauli GF. Structural Sequencing of Oligopeptides Aided by 1H Iterative Full-Spin Analysis.. Journal of natural products. 2017;80(10):2630-2643. doi:10.1021/acs.jnatprod.7b00207. Friesen JB, McAlpine JB, Chen S, Pauli GF. (2017). The 9th International Countercurrent Chromatography Conference held at Dominican University, Chicago, USA, August 1-3, 2016.. Journal of chromatography. A. Vol. 1520. Page(s) 1-8. Keiler AM, Helle J, Bader MI, Ehrhardt T, Nestler K, Kretzschmar G, Bernhardt R, Vollmer G, Nikolić D, Bolton JL, Pauli GF, Chen S, Dietz BM, van Breemen RB, Zierau O. A standardized Humulus lupulus (L.) ethanol extract partially prevents ovariectomy-induced bone loss in the rat without induction of adverse effects in the uterus.. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2017;34:50-58. doi:10.1016/j.phymed.2017.08.001. Warit S, Rukseree K, Prammananan T, Hongmanee P, Billamas P, Jaitrong S, Chaiprasert A, Jaki BU, Pauli GF, Franzblau SG, Palittapongarnpim P. In Vitro Activities of Enantiopure and Racemic 1′-Acetoxychavicol Acetate against Clinical Isolates of Mycobacterium tuberculosis.. Scientia pharmaceutica. 2017;85(3). doi:10.3390/scipharm85030032. Simmler C, Lankin DC, Nikolić D, van Breemen RB, Pauli GF. Isolation and structural characterization of dihydrobenzofuran congeners of licochalcone A.. Fitoterapia. 2017;121:6-15. doi:10.1016/j.fitote.2017.06.017. Dietz BM, Chen S, Alvarenga RFR , Dong H, Nikolić D, Biendl M, van Breemen RB, Bolton JL, Pauli GF. DESIGNER Extracts as Tools to Balance Estrogenic and Chemopreventive Activities of Botanicals for Women’s Health.. Journal of natural products. 2017;80(8):2284-2294. doi:10.1021/acs.jnatprod.7b00284. Melchor-Martínez EM, Silva-Mares DA, Torres-López E, Waksman-Minsky N, Pauli GF, Chen S, Niemitz M, Sánchez-Castellanos M, Toscano A, Cuevas G, Rivas-Galindo VM. Stereochemistry of a Second Riolozane and Other Diterpenoids from Jatropha dioica.. Journal of natural products. 2017;80(8):2252-2262. doi:10.1021/acs.jnatprod.7b00193. Jaja-Chimedza A, Graf BL, Simmler C, Kim Y, Kuhn P, Pauli GF, Raskin I. Biochemical characterization and anti-inflammatory properties of an isothiocyanate-enriched moringa (Moringa oleifera) seed extract.. PloS one. 2017;12(8):e0182658. doi:10.1371/journal.pone.0182658. Liu Y, Friesen JB, Grzelak E, Fan Q, Tang T, Durić K, Jaki BU, McAlpine JB, Franzblau SG, Chen S, Pauli GF. Sweet spot matching: A thin-layer chromatography-based countercurrent solvent system selection strategy.. Journal of chromatography. A. 2017;1504:46-54. doi:10.1016/j.chroma.2017.04.055. AbouZid SF, Ahmed HS, Moawad AS, Owis AI, Chen S, Nachtergael A, McAlpine JB, Brent Friesen J, Pauli GF. Chemotaxonomic and biosynthetic relationships between flavonolignans produced by Silybum marianum populations.. Fitoterapia. 2017;119:175-184. doi:10.1016/j.fitote.2017.04.002.