Coughlan, Melinda - Monash University - Central Clinical School

个人简介

Associate Professor Melinda Coughlan has a BSc (Biology) with Honours in Human Nutrition from Deakin University, and a PhD in Obstetrics & Gynaecology from the University of Melbourne. Her PhD focused on mediators of inflammation and oxidative stress in the development of gestational diabetes (Mercy Hospital for Women). After completing her PhD, Melinda joined the Baker Heart Research Institute as a postdoctoral researcher in Prof Mark Cooper’s Diabetes Complications Division. In 2012, she became the Head of the Glycation, Nutrition and Metabolism Laboratory at the Baker IDI Heart and Diabetes Institute. In Nov 2016, she was recruited to Monash University’s Central Clinical School as one of the key recruits to help establish the Department of Diabetes. Associate Professor Coughlan holds a Career Development Fellowship from the JDRF and has research grants from the NHMRC. Achievements and Awards JDRF Career Development Award Nutrition Society of Australia Mid Career Research Award Roche-Australian and New Zealand Society of Nephrology Senior Scientist Career Development Award Australian Diabetes Society Skip Martin Early Career Fellowship National Health and Medical Research Council of Australia (NHMRC) New Investigator Project Grant Registered Nutritionist (Nutrition Society of Australia)

研究领域

Dietary factors in the initiation of diabetes and its complications: Maillard reaction products/advanced glycation end-products (AGEs). Dietary constituents and incretins (GLP-1). Ultraprocessed foods and gut microbial ecology. Mitochondrial health in diabetes: Mapping the mitochondrial bioenergetic signature of individuals with diabetic kidney disease. Investigating pathways of mitochondrial quality control. Validation of mitochondria-targeted therapies in pre-clinical models. Identification of novel targets of therapy for chronic kidney disease: Multiomic profiling of human renal biospecimens from subjects with diabetes and kidney disease.

近期论文

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Gut microbiome, prebiotics, intestinal permeability and diabetes complications Snelson, M., de Pasquale, C., Ekinci, E. I. & Coughlan, M. T., 17 Feb 2021, (Accepted/In press) In : Best Practice and Research: Clinical Endocrinology and Metabolism. 13 p., 101507. Long Term High Protein Diet Feeding Alters the Microbiome and Increases Intestinal Permeability, Systemic Inflammation and Kidney Injury in Mice Snelson, M., Clarke, R. E., Nguyen, T. V., Penfold, S. A., Forbes, J. M., Tan, S. M. & Coughlan, M. T., 6 Feb 2021, (Accepted/In press) In : Molecular Nutrition & Food Research. 12 p. Processed foods drive intestinal barrier permeability and microvascular diseases Snelson, M., Tan, S. M., Clarke, R. E., de Pasquale, C., Thallas-Bonke, V., Nguyen, T-V., Penfold, S. A., Harcourt, B. E., Sourris, K. C., Lindblom, R. S. J., Ziemann, M., Steer, D., El-Osta, A., Davies, M. J., Donnellan, L., Deo, P., Kellow, N. J., Cooper, M. E., Woodruff, T. M., Mackay, C. R. & 2 others, , 31 Mar 2021, In : Science Advances. 7, 14, 15 p., eabe4841. Complement C5a induces renal injury in diabetic kidney disease by disrupting mitochondrial metabolic agility Tan, S. M., Ziemann, M., Thallas-Bonke, V., Snelson, M., Kumar, V., Laskowski, A., Nguyen, T. V., Huynh, K., Clarke, M. V., Libianto, R., Baker, S. T., Skene, A., Power, D. A., MacIsaac, R. J., Henstridge, D. C., Wetsel, R. A., El-Osta, A., Meikle, P. J., Wilson, S. G., Forbes, J. M. & 4 others, , 1 Jan 2020, In : Diabetes. 69, 1, p. 83-98 16 p. Confirmation of the Cardioprotective Effect of MitoGamide in the Diabetic Heart Park, M., Nishimura, T., Baeza-Garza, C. D., Caldwell, S. T., Pun, P. B. L., Prag, H. A., Young, T., Sauchanka, O., Logan, A., Forkink, M., Gruszczyk, A. V., Prime, T. A., Arndt, S., Naudi, A., Pamplona, R., Coughlan, M. T., Tate, M., Ritchie, R. H., Caicci, F., Kaludercic, N. & 5 others, , Dec 2020, In : Cardiovascular Drugs and Therapy. 34, 6, p. 823-834 12 p. Correction to: The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart (Cardiovascular Drugs and Therapy, (2019), 33, 6, (669-674), 10.1007/s10557-019-06914-9) Tate, M., Higgins, G. C., De Blasio, M. J., Lindblom, R., Prakoso, D., Deo, M., Kiriazis, H., Park, M., Baeza-Garza, C. D., Caldwell, S. T., Hartley, R. C., Krieg, T., Murphy, M. P., Coughlan, M. T. & Ritchie, R. H., 1 Apr 2020, In : Cardiovascular Drugs and Therapy. 34, 2, p. 223 1 p. Deficiency of Prebiotic Fiber and Insufficient Signaling through Gut Metabolite-Sensing Receptors Leads to Cardiovascular Disease Kaye, D. M., Shihata, W. A., Jama, H. A., Tsyganov, K., Ziemann, M., Kiriazis, H., Horlock, D., Vijay, A., Giam, B., Vinh, A., Johnson, C., Fiedler, A., Donner, D., Snelson, M., Coughlan, M. T., Phillips, S., Du, X-J., El-Osta, A., Drummond, G., Lambert, G. W. & 4 others, , 28 Apr 2020, In : Circulation. 141, 17, p. 1393-1403 11 p. Delineating a role for the mitochondrial permeability transition pore in diabetic kidney disease by targeting cyclophilin D Lindblom, R. S. J., Higgins, G. C., Nguyen, T. V., Arnstein, M., Henstridge, D. C., Granata, C., Snelson, M., Thallas-Bonke, V., Cooper, M. E., Forbes, J. M. & Coughlan, M. T., 29 Jan 2020, In : Clinical Science. 134, 2, p. 239-259 21 p. Exploring the role of the metabolite-sensing receptor GPR109a in diabetic nephropathy Snelson, M., Tan, S. M., Higgins, G. C., Lindblom, R. S. J. & Coughlan, M. T., 1 Mar 2020, In : American Journal of Physiology-Renal Physiology. 318, 3, p. F835-F842 8 p. Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes Davey, J. R., Estevez, E., Thomson, R. E., Whitham, M., Watt, K. I., Hagg, A., Qian, H., Henstridge, D. C., Ludlow, H., Hedger, M. P., McGee, S. L., Coughlan, M. T., Febbraio, M. A. & Gregorevic, P., Apr 2020, In : The FASEB Journal. 34, 4, p. 5697-5714 18 p. Mutation of regulatory phosphorylation sites in PFKFB2 worsens renal fibrosis Lee, M., Harley, G., Katerelos, M., Gleich, K., Sullivan, M. A., Laskowski, A., Coughlan, M., Fraser, S. A., Mount, P. F. & Power, D. A., 3 Sep 2020, In : Scientific Reports. 10, 1, 12 p., 14531. The Devil's in the Detail: The Importance of Specific, Descriptive Language for Reproducibility in Nutrition Science Snelson, M. & Coughlan, M., Jul 2020, In : Journal of Renal Nutrition. 30, 4, p. 274-275 2 p. Dietary Advanced Glycation End Products: Digestion, Metabolism and Modulation of Gut Microbial Ecology Snelson, M. & Coughlan, M. T., 22 Jan 2019, In : Nutrients. 11, 2, 15 p., 215. Globally elevating the AGE clearance receptor, OST48, does not protect against the development of diabetic kidney disease, despite improving insulin secretion Zhuang, A., Yap, F. Y. T., McCarthy, D., Leung, C., Sourris, K. C., Penfold, S. A., Thallas-Bonke, V., Coughlan, M. T., Schulz, B. L. & Forbes, J. M., 20 Sep 2019, In : Scientific Reports. 9, 1, 10 p., 13664. Gut feelings: What happens when Maillard reaction products meet the gut microbiota? Snelson, M. & Coughlan, M., 15 Jul 2019, IMARS Highlights, 14, 4, p. 5-10 6 p. Modulation of the Gut Microbiota by Resistant Starch as a Treatment of Chronic Kidney Diseases: Evidence of Efficacy and Mechanistic Insights Snelson, M., Kellow, N. J. & Coughlan, M., 1 Mar 2019, In : Advances in Nutrition. 10, 2, p. 303-320 18 p. Nourishing Australia: A decadal plan for the science of nutrition Gidley, M., Simpson, S., Coughlan, M., Noakes, M., Raubenheimer, D. & Truby, H., Jul 2019, Australia: Australian Academy of Science. 42 p. The Mitochondria-Targeted Methylglyoxal Sequestering Compound, MitoGamide, Is Cardioprotective in the Diabetic Heart Tate, M., Higgins, G., De Blasio, M. J., Lindblom, R., Prakoso, D., Deo, M., Kiriazis, H., Park, M., Baeza-Garz, C. D., Caldwell, S. T., Hartley, R. C., Krieg, T., Murphy, M. P., Coughlan, M. & Ritchie, R. H., Dec 2019, In : Cardiovascular Drugs and Therapy. 33, 6, p. 669-674 6 p. Association between habitual dietary and lifestyle behaviours and skin autofluorescence (SAF), a marker of tissue accumulation of advanced glycation endproducts (AGEs), in healthy adults Kellow, N. J., Coughlan, M. T. & Reid, C. M., Sep 2018, In : European Journal of Nutrition. 57, 6, p. 2209-2216 8 p. Methods in renal research: Measurement of autophagic flux in the renal cortex ex vivo Higgins, G. C., Nguyen, T-V., Ramm, G. & Coughlan, M. T., 1 Sep 2018, In : Nephrology. 23, 9, p. 815-820 6 p.