个人简介

B.S. 1967, National Taiwan University M.Ph. 1970, Yale University Ph.D. 1972, Yale University

研究领域

Biophysical Chemistry

Biophysical and biological chemistry, polyamines in cancer and aging Specific areas of current interest in the lab are: Function of polyamines; Biochemistry of hypusine formation and eukaryotic initiation factor 5A (eIF5A); Mechanism of the action of nutraceuticals; Stress and heat shock factor activation.

近期论文

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Oza, J., Yang, J., Chen, K.Y. and Liu, A.Y-C. Changes in the regulation of heat shock gene expression in neuronal cell differentiation. Cell Stress and Chaperons, 13, 73-84, 2008. Gosslau, A., Pabbaraja, S., Knapp and Chen, K.Y. Trans- and cis-stilbene polyphenols induced rapid perinuclear mitochondrial clustering and p53-independent apoptosis in cancer cells but not normal cells. European J. Pharmacology, 587, 25-34, 2008. Yang, J., Oza, J., Bridges, K, Chen, K.Y. Liu, A.Y.-C. Neural differentiation and the attenuated heat shock response. Brain Research, 1203, 39-50, 2008. Yang, J., Bridges, K., Chen, K.Y. and Liu, A. Y.-C. Riluzole increases the amount of latent HSF1 for an amplified heat shock response and cytoprotection. PloS ONE 1-11, 2008 Lu, J., Gosslau, A. , Liu, A.Y.-C. and Chen, K.Y. PCR differential display-based identification of regulator of G protein signaling 10 as the target gene in human colon cancer cells induced by black tea polyphenol theaflavin monogallate. European J Pharmacology, 601, 66-72, 2008 Lee, Y.K. , Liu, D., Lu , J., Chen, K.Y. and Liu, A. Y.-C. Aberrant regulation and modification of heat shock factor 1 in senescent human diploid fibroblasts. J. Cell Biochem. 106, 267-278, 2009 Gosslau, A., Jao, D., Liu, A.Y-C. and Chen, K.Y. Thermal killing of human colon cancer cells Is associated with the loss of eukaryotic initiation factor 5A. J Cell Physiol, 219, 485-493, 2009 Jao, D.L. and Chen, K.Y. Subcellular localization of the hypusine-containing eukaryotic initiation factor 5A by immunofluorescent staining and Green Fluorescent protein tagging. J. Cell. Biochem., 86, 590-600, 2002. Matuoka, K. and Chen, K.Y. Transcriptional regulation of cellular senescence by the CCAAT box-binding proteins CBF/NF-Y. Aging Research Reviews, 1, 639-651, 2002. Matuoka, K. and Chen, K.Y. Telomerase positive human diploid fibroblasts are resistant to replicative senescence but not premature senescence induced by chemical reagents. Biogerontology, 3, 365-372, 2002. Matuoka, K., Chen, K.Y. and Takenawa, T. A positive role of phosphatidylinositol 3-kinase in aging phenotype expression in cultured human diploid fibroblasts. Archives Gerontology and Geriatrics, ,36, 203-219, 2003. Gosslau, A. and Chen, K.Y. Nutraceuticals, apoptosis, and disease prevention. Nutrition, 20, 95 102, 2004, Xu, A.Jao, D.L. and Chen, K.Y. Identification of messenger RNA species that bind specifically to eukaryotic initiation factor 5A by affinity co-purification and differential display. Biochemical Journal, 384, 585-590, 2004 Gosslau, A., Chen, M., Ho, C.-T. and Chen, K.Y. A methoxy derivative of resveratrol analog exhibits potent and striking differential growth inhibitory effect against human cancer cells. British J. Cancer, 92, 513-521, 2005. Fang, F., Sang, S., Chen, K.Y., Gosslau, A., Ho, C.-T., and Rosen, R.T. Isolation and identification of cytotoxic compounds from bay leaf (Laurus nobilis). Food Chem., 93, 497-501, 2005 Chatterjee I, Gross SR, Kinzy TG, Chen KY. Rapid depletion of mutant eukaryotic initiation factor 5A at restrictive temperature reveals connections to actin cytoskeleton and cell cycle progression. Mol Genet Genomics. 275:264-276, 2006 Jao DL, Chen KY. Tandem affinity purification revealed the hypusine-dependent binding of eukaryotic initiation factor 5A to the translating 80S ribosomal complex. J Cell Biochem. 97:583-598, 2006