个人简介
招生专业
071005-微生物学
081703-生物化工
招生方向
微生物代谢工程和比较基因组学
教育背景
1997-09--2001-09 日本九州工业大学 获得博士学位
1994-09--1997-08 浙江大学 获得硕士学位
1990-09--1994-08 浙江大学 获得学士学位
工作简历
2008-07~现在, 中国科学院上海生命科学研究院植物生理生态研究所, 研究员
2004-05~2008-07,美国Burnham医学研究所, 博士后
2001-10~2004-04,日本庆应大学，先端生命科学研究所, 博士后
专利与奖励
2010.09.032015.11.2514ZL201310128943.8利用蓝藻生产异戊二烯 杨琛，高翔，刘邓，高方
近期论文
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Xiaoqun Nie, Hua Qiang, Xu Ping, Chen Yang* (2020) Biological insights into non-model microbial hosts through stable-isotope metabolic flux analysis. Current Opinion in Biotechnology 64:32.
Ningning Zhuang#, Hao Zhang#, Lingting Li, Xiaoxian Wu, Chen Yang*, Yu Zhang* (2020) Crystal structures and biochemical analyses of the bacterial arginine dihydrolase ArgZ suggests a "bond rotation" catalytic mechanism. Journal of Biological Chemistry 295: 2113-2124.
Bin Yang, Xiaoqun Nie, Yang Gu, Weihong Jiang, Chen Yang* (2020) Ferrous-Iron-Activated Transcriptional Factor AdhR Regulates Redox Homeostasis in Clostridium beijerinckii. Applied Environmental Microbiology 86:e02782-19.
Bin Yang, Xiaoqun Nie, Yang Gu, Weihong Jiang, Chen Yang* (2020) Control of solvent production by sigma-54 factor and the transcriptional activator AdhR in Clostridium beijerinckii. Microbial biotechnology 13: 328-338.
Xuejing Liu, Li Xie, Kuo Du, Chang Liu, Ningping Zhang, Chenjian Gu, Ying Wang, Manal F. Abdelmalek, Wenyue Dong, Xiuping Liu, Chen Niu*, Chen Yang, Anna Mae Diehl*, Jian Wu* (2020) Succinate-GPR-91 receptor signaling is responsible for nonalcoholic steatohepatitis-associated fibrosis: effects of DHA supplementation. Liver International 40: 830-843.
Xiaoqun Nie, Wenyue Dong, Chen Yang* (2019) Genomic reconstruction of sigma(54) regulons in Clostridiales. BMC Genomics 20:565.
Hao Zhang, Chen Yang* (2019) Arginine and nitrogen mobilization in cyanobacteria. Molecular Microbiology 111:863-867.
Hao Zhang, Yujie Liu, Xiaoqun Nie, Lixia Liu, Qiang Hua, Guo-Ping Zhao, Chen Yang* (2018) The cyanobacterial ornithine-ammonia cycle involves an arginine dihydrolase. Nature Chemical Biology 14: 575-581.
Yunpeng Yang#, Xiaoqun Nie#, Yuqian Jiang, Chen Yang*, Yang Gu*, Weihong Jiang* (2018) Metabolic regulation in solventogenic clostridia: regulators, mechanisms and engineering. Biotechnology Advances 36: 905-914.
Yangyang Shao, Ning Lu, Zhenfang Wu, Chen Cai, Shanshan Wang, Lingli Zhang, Fan Zhou, Shijun Xiao, Lin Liu, Xiaofei Zeng, Huajun Zheng, Chen Yang, Zhihu Zhao, Guo-Ping Zhao*, Jin-Qiu Zhou*, Xiaoli Xue*, Zhongjun Qin* (2018) Creating a functional single-chromosome yeast. Nature 560: 331-335.
Manman Zhang, Chao Gao*, Xiaoting Guo, Shiting Guo, Zhaoqi Kang, Dan Xiao, Jinxin Yan, Fei Tao, Wen Zhang, Wenyue Dong, Pan Liu, Chen Yang, Cuiqing Ma, Ping Xu* (2018) Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving L-2-hydroxyglutarate. Nature Communications 9: 2114
5. Elizabeth Brunk, Roger L. Chang, Jing Xia, Hooman Hefzi, James T. Yurkovich, Donghyuk Kim, Evan Buckmiller, Harris H. Wang, Byung-Kwan Cho, Chen Yang, Bernhard O. Palsson, George M. Church, Nathan E. Lewis (2018) Characterizing posttranslational modifications in prokaryotic metabolism using a multiscale workflow. Proceedings of the National Academy of Sciences of the United States of America 115(43): 11096-11101.
Xiang Gao, Fang Gao, Deng Liu, Hao Zhang, Xiaoqun Nie, Chen Yang* (2016) Engineering the methylerythritol phosphate pathway in cyanobacteria for photosynthetic isoprene production from CO2. Energy and Environmental Science 9: 1400-1411.
Chen Yang#, Xiang Gao#, Yu Jiang#, Bingbing Sun, Fang Gao, Sheng Yang* (2016) Synergy between methylerythritol phosphate pathway and mevalonate pathway for isoprene production in Escherichia coli.
Xiaoqun Nie#, Bin Yang#, Lei Zhang, Yang Gu, Sheng Yang, Weihong Jiang, Chen Yang* (2016) PTS regulation domain-containing transcriptional activator CelR and sigma factor σ54 control cellobiose utilization in Clostridium acetobutylicum. Molecular Microbiology 100: 289-302.
Jingfeng Tong#, Lu Meng#, Xinwei Wang#, Lixia Liu#, Liangdong Lyu, Chuan Wang, Yang Li, Qian Gao, Chen Yang*, Chen Niu* (2016) The FBPase encoding gene glpX is required for gluconeogenesis, bacterial proliferation and division in vivo of Mycobacterium marinum. PLoS ONE 11(5): e0156663.
Aiyou Huang, Lixia Liu, Peipei Zhao,Chen Yang *, Guangce Wang* (2016) Metabolic flux ratio analysis and cell staining suggest the existence of C4 photosynthesis in Phaeodactylum tricornutum. Journal of Applied Microbiology 120(3): 705-713.
Deng Liu and Chen Yang* (2014) The nitrogen-regulated response regulator NrrA controls cyanophycin synthesis and glycogen catabolism in the cyanobacterium Synechocystis sp. PCC 6803. Journal of Biological Chemistry 289: 2055-2071.
Lei Zhang, Xiaoqun Nie, Dmitry Ravcheev, Dmitry Rodionov, Jia Sheng, Yang Gu, Sheng Yang, Weihong Jiang, Chen Yang* (2014) Redox-responsive repressor Rex modulates alcohol production and oxidative stress tolerance in Clostridium acetobutylicum. Journal of Bacteriology 196(22): 3949-3963.
Dongfeng Liu, Guomin Ai, Qingxiang Zheng, Chang Liu, Chengying Jiang, Lixia Liu, Bo Zhang, Yiming Liu, Chen Yang*, Shuangjiang Liu* (2014) Metabolic flux responses to genetic modification for shikimic acid production by Bacillus subtilis strains. Microbial Cell Factory 13(1): 40.
Yongzhen Tao#, Deng Liu#, Xing Yan, Zhihua Zhou, Jeong K. Lee, Chen Yang* (2012) Network identification and flux quantification of glucose metabolism in under photoheterotrophic H2-producing conditions. Journal of Bacteriology 194(2): 274-283.
Lixia Liu#, Lei Zhang#, Wei Tang, Yang Gu, Qiang Hua, Sheng Yang, Weihong Jiang, Chen Yang* (2012) Phosphoketolase pathway for xylose catabolism in Clostridium acetobutylicum revealed by 13C metabolic flux analysis. Journal of Bacteriology 194(19): 5413-5422.
Semen A. Leyn#, Fang Gao#, Chen Yang*, Dmitry A. Rodionov* (2012) N-Acetylgalactosamine utilization pathway and regulon in proteobacteria. Genomic reconstruction and experimental characterization in Shewanella. Journal of Biological Chemistry 287(33): 28047-56.
Yang Gu#, Yi Ding#, Cong Ren, Zhe Sun, Dmitry A. Rodionov, Weiwen Zhang, Sheng Yang, Chen Yang*, Weihong Jiang* (2010) Reconstruction of xylose utilization pathway and regulons in Firmicutes. BMC Genomics 11: 255.
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