王四宝 - 中国科学院大学

个人简介

招生专业 071002-动物学招生方向媒介昆虫与微生物相互作用，昆虫微生物组学蚊媒传染病昆虫微生物组学教育背景 2003-09--2006-12 中国科学院上海生命科学研究院博士工作简历 2019-05~现在, 中国科学院分子植物科学卓越创新中心, 研究员 2013-02~2019-04,中国科学院上海生命科学研究院植物生理生态所, 研究员 2009-09~2013-02,美国约翰霍普金斯大学, 博士后 2007-01~2009-08,美国马里兰大学, 博士后 2003-09~2006-12,中国科学院上海生命科学研究院, 博士 2000-07~2003-06,安徽农业大学, 讲师、副教授教授课程现代昆虫学奖励信息（1）真菌杀虫剂产业化及森林害虫持续控制技术, 二等奖, 国家级, 2009 （2）真菌杀虫剂产业化及森林害虫持续控制技术的研究, 一等奖, 省级, 2008 （3）虫草和近缘属及其无性型的物种多样性和遗传多样性的研究, 一等奖, 省级, 2006 专利成果（ 1 ） Genetically containing transgenic pathogens by disrupting their ability to survive outside the host, particularly in soils, 2012, 第 2 作者, 专利号: 35 U.S.C.18 （ 2 ）一种松褐天牛引诱剂及其应用, 2005, 第 2 作者, 专利号: CN1709068 （ 3 ）松材线虫的微卫星扩增引物、检测方法及检测试剂盒, 2003, 第 3 作者, 专利号: 200310109374.9 发表著作 The use of semiochemicals and the fungus Beauveria bassiana to control the vector beetle Monochamus alternatus of pine wilt disease. In Kiyoshi Nakamuta, Jocelyn G. Millar (Ed). Chemical ecology of wood-boring insects (pp.80-98), Chemical ecology of wood-boring insects (pp.80-98). Tsukuba: The Forestry and Forest Products Research Institute, 2009-08, 第 1 作者（ 2 ）昆虫信息素研究进展。孔垂华和娄永根主编《化学生态学前沿》pp.1-38, 2010, 2010-06, 第 1 作者 Paratransgenesis applications: fighting malaria with engineered mosquito symbiotic bacteria, Elsevier, 2018-05, 第 1 作者科研项目（ 1 ）按蚊中肠共生细菌Serratia sp.阻断疟疾传播的分子机理, 主持, 国家级, 2015-01--2018-12 （ 2 ）种内信息流靶标分子的遗传转化技术体系构建, 主持, 部委级, 2014-07--2019-06 （ 3 ）按蚊中肠共生菌阻断疟疾传播的分子机制, 主持, 省级, 2014-07--2016-06 （ 4 ）杀虫真菌-昆虫寄主互作的表观遗传调控机制, 主持, 国家级, 2017-07--2020-12 （ 5 ）肠道微生物促进真菌杀蚊的机制研究, 主持, 国家级, 2018-01--2021-12 （ 6 ）中科院****终期评估优秀, 主持, 部委级, 2018-01--2020-12 （ 7 ）中华按蚊肠道共生菌协同抗疟的分子机制, 主持, 国家级, 2019-01--2023-12 （ 8 ）高版本工业丝状真菌底盘构建, 主持, 国家级, 2019-07--2024-06 参与会议（1）病原真菌与宿主昆虫互作的表观遗传机制 2019-12-27 （2）致病真菌与昆虫互作的表观遗传机制 2019-12-21 （3）生防真菌与昆虫互作的表观遗传机制 2019-12-21 （4）昆虫微生物组与宿主互作的分子机制 2019-12-14 （5）A fungal pathogen deploys a small RNA to suppress mosquito immunity by hijacking the host RNAi machinery 2019-09-06 （6）The fungal pathogen deploys a small RNA to suppress mosquito immunity by hijacking the host RNAi machinery 2019-07-19 （7）Microbiota in mosquitoes: their roles in infection and disease control 2019-04-10 （8）Symbiotic bacteria in the Anopheles mosquito: their roles in infection and malaria control 2018-10-27 （9）Paratransgenesis for vector-born disease control 2018-10-20 （10）Symbiotic bacteria in the Anopheles mosquito: their roles in infection and malaria control 2018-08-19 （11）Paratransgenesis for vector-born diseases control 2018-08-15 （12）The entomopathogenic fungus recruits gut microbiota to kill mosquitoes 2017-08-17 （13）Blocking malaria transmission with engineered symbiotic bacteria from vector mosquitoes 2016-11-09 （14）Histone Methyltransferases Regulate Fungal Pathogenesis and Stress Tolerance in Mosquito Fungal Pathogen Metarhizium robertsii 第十二届海峡两岸菌物学学术研讨会 2015-11-06 （15）Regulation mechanism of H3K4 and H3K36 methylation in fungal sporulation and its interaction with insect host 2015-03-12 （16）昆虫共生菌功能基因组研究中国昆虫学会2014年学术年会 2014-10-22 （17）Genetic basis of local adaptation of an introduced fungal entomopathoge 第十届国际真菌学大会 2014-08-03 （18）昆虫真菌光受体蛋白MVVD及其功能研究第五届全国农业微生物研究及产业化研讨会 2014-07-18 （19）利用昆虫共生菌阻断疾病传播中国昆虫学会2013年学术年会 2013-10-15 （20）Fighting malaria with engineered symbiotic bacteria from vector mosquitoes 第五次国际寄生虫学学术研讨会 2013-07-31 （21）Fighting Malaria with Engineered Symbiotic Bacteria from Vector Mosquitoes 2013-05-27 （22）Toward Paratransgenesis: Identification of a Symbiotic Bacterium that is Vertically and Horizontally Transmitted by Vector Mosquitoes 2013-05-22

近期论文

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（1） Coordinated regulation of infection-related morphogenesis by the KMT2-Cre1-Hyd4 regulatory pathway to facilitate fungal infection, Science Advances, 2020, 通讯作者（2） Use of microbiota to fight mosquito-borne disease, Frontiers in Genetics, 2020, 第 2 作者（3） Mosquito microbiota and implications for disease control, Trends in Parasitology, 2020, 通讯作者（4） Genomic landscape and genetic manipulation of the black soldier fly Hermetia illucens, a natural waste recycler, Cell Research, 2019, 其他（合作组作者）（5） A fungal pathogen deploys a small RNA to attenuate mosquito immunity and facilitate infection, Nature Communications, 2019, 通讯作者（6） A gut symbiotic bacterium Serratia marcescens renders mosquito resistance to Plasmodium infection through activation of mosquito immune responses, Frontiers in Microbiology, 2019, 通讯作者（7） Interaction of entomopathogenic fungi with the host immune system, Developmental and Comparative Immunology, 2018, 通讯作者（8） Driving mosquito refractoriness to Plasmodium falciparum with engineered symbiotic bacteria, Science, 2017, 通讯作者（9） Insect pathogenic fungus interacts with the gut microbiota to accelerate mosquito mortality, PNAS, 2017, 通讯作者（10） CRISPR/Cas9-mediated efficient genome editing via blastospore-based transformation in entomopathogenic fungus Beauveria bassiana, Scientific Reports, 2017, 通讯作者（11） Insect pathogenic fungi: genomics, molecular interactions, and genetic improvements., Annual Review of Entomology, 2017, 第 2 作者（12） In vivo gene expression profiling of the entomopathogenic fungus Beauveria bassiana elucidates its infection stratagems in mosquito., Science China Life Science, 2017, 通讯作者（13）蚊媒传染病的遗传控制和共生控制, 应用昆虫学报, 2015, 通讯作者（14） Genome-wide analysis of DNA methylation in the sexual stage of the insect pathogenic fungus Cordyceps militaris, Fungal Biology, 2015, 通讯作者（15） Transmission Risk from Imported Plasmodium vivax Malaria in the China-Myanmar Border Region, Emerg Infection Disease, 2015, 通讯作者（16） Genetic approaches to interfere with malaria transmission by vector mosquito, Trends in Biotechnology, 2013, 通讯作者（17） Fighting malaria with engineered symbiotic bacteria from vector mosquitoes, PNAS, 2012, 第 1 作者（18） Local adaptation of an introduced transgenic insect fungal pathogen due to new beneficial mutations, PNAS, 2011, 第 1 作者（19） Insertion of an esterase gene into a specific locust pathogen (Metarhizium acridum) enables it to infect caterpillars, PLoS Pathogens, 2011, 第 1 作者（20） Comparative genomics using microarrays reveals divergence and loss of virulence associated genes in host specific strains of the insect pathogen Metarhizium anisopliae, Eukaryotic Cell, 2009, 第 1 作者（21） The structure of the bacterial and archaeal community in a biogas digester as revealed by denaturing gradient gel electrophoresis and 16S rDNA sequencing analysis, Journal of Applied Microbiology, 2009, 第 1 作者（22） Genetic diversity and population structure among strains of the entomopathogenic fungus, Beauveria bassiana, as revealed by inter-simple sequence repeats (ISSR), Mycological Research, 2005, 第 1 作者

学术兼职

2019-09-20-今,上海市昆虫学会, 理事长 2018-01-01-今,Frontiers in Microbiology, Associate Editor 2017-07-01-今,中国菌物学会菌物组学专业委员会, 主任 2017-07-01-今,中国昆虫学会昆虫微生物组专业委员会, 副主任 2017-07-01-今,中国昆虫学会昆虫比较免疫与互作专业委员会, 副主任 2014-07-01-今,中国菌物学会, 副秘书长