个人简介
招生专业
070301-无机化学
070302-分析化学
0703J1-纳米科学与技术
招生方向
纳米材料,生物传感, 生物成像
教育背景
1998-09--2003-07 中国科学院上海应用物理研究所 博士学位
工作简历
2018-10~现在, 中国科学院上海高等研究院,上海光源, 研究员
2014-12~2018-10,中国科学院上海应用物理研究所, 研究员
2008-01~2014-12,中国科学院上海应用物理研究所, 副研究员
2003-07~2007-12,中国科学院上海应用物理研究所, 助理研究员
1998-09~2003-07,中国科学院上海应用物理研究所, 博士学位
奖励信息
(1) 国家自然科学奖, 二等奖, 国家级, 2016
(2) 上海市三八红旗手, 省级, 2016
(3) 上海自然科学奖, 一等奖, 省级, 2014
(4) 上海市科技系统三八红旗手十佳, , 其他, 2012
(5) 中国科学院青年促进会会员, , 院级, 2011
(6) 中国分析测试协会科学技术奖, 一等奖, 其他, 2008
(7) 上海市科技系统三八红旗手, , 市地级, 2008
(8) 上海市青年启明星, , 省级, 2008
(9) 中国科学院卢嘉锡青年人才奖, , 院级, 2008
(10) 中国分析测试协会科学技术奖, 一等奖, 其他, 2007
专利成果
( 1 ) 一种基于同步光源的X-射线遗传标记探针及其制备方法以及应用, 2020, 第 5 作者, 专利号: ZL201710228597.9
( 2 ) 一种基于超连续激光器构建的多模式全光谱暗场显微镜及其应用, 2018, 第 2 作者, 专利号: 201810661599.1
( 3 ) 一种检测目标DNA或miRNA的方法, 2018, 第 2 作者, 专利号: 201810516888.2
( 4 ) 一种基于DNA纳米结构的多色荧光探针及其制备方法以及应用, 2020, 第 1 作者, 专利号: 202010334213.3
( 5 ) 一种用于大尺寸脑组织的高效的高尔基染色方法, 2020, 第 3 作者, 专利号: 202010104757
( 6 ) 一种光生物学制氢体系及其制备方法以及应用, 2020, 第 3 作者, 专利号: 202010104558.X
( 7 ) 一种磁性纳米材料介导的CRISPR/Cas9 T细胞内递送系统及其制备方法和应用, 2020, 第 3 作者, 专利号: ZL201710728571.0
发表著作
( 1 ) 功能纳米材料用于生物分析,纳米药物和生物电子器件--第4章, Functional nanoparticles for bioanalysis, nanomedicine, and bioelectronic devices--Chapter 4, ACS , 2012-04, 第 2 作者
科研项目
( 1 ) 生物探针的设计和研制, 主持, 国家级, 2013-01--2017-12
( 2 ) 基于同步辐射 X 射线集成技术的细胞高分辨成像方法与研究, 主持, 国家级, 2016-07--2021-06
( 3 ) 细胞内单颗粒示踪显微系统的研制, 主持, 部委级, 2016-01--2017-12
( 4 ) 动态调控的DNA“纳米开关”在肿瘤诊断与治疗中的应用, 主持, 国家级, 2017-01--2020-12
研究领域
2020-01-01-今,第四届抗菌科学与技术论坛学术委员会, 委员
2016-05-10-今,生物物理学会规划发展委员会, 副主任
近期论文
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(1) Treating acute kidneyinjury with antioxidative black phosphorus nanosheets, Nano Letters, 2020, 通讯作者
(2) DNA Nanoribbon-templated Self-assembly of ultrasmall fluorescent copper nanoclusters with enhanced luminescence, Angewandte Chemie International Edition, 2020, 通讯作者
(3) DNA origami radiometers for measuring ultraviolet exposure, Journal of the American Chemical Society, 2020, 通讯作者
(4) Implementing digital computing with DNA-based switching circuits, Nature Communications, 2020, 通讯作者
(5) Encoding quantized fluorescence states with fractal DNA frameworks, Nature Communications, 2020, 通讯作者
(6) Prescribing DNA Origami Patterns via Scaffold Decoration, Small, 2020, 通讯作者
(7) Mechanical stress-dependent autophagy component release via extracellular nanovesicles in tumor cells, ACS Nano, 2019, 通讯作者
(8) Epitope Binning Assay Using an Electron Transfer-Modulated Aptamer Sensor., Acs Applied Materials & Interfaces, 2018, 通讯作者
(9) Nanodiamond autophagy inhibitor allosterically improves the arsenical-based therapy of solid tumors, Nature Communications, 2018, 通讯作者
(10) Graphene oxide-silver nanocomposites modulate biofilm formation and extracellular polymeric substance (EPS) production, Nanoscale, 2018, 通讯作者
(11) Serum protein corona-responsive autophagy tuning in cells, Nanoscale, 2018, 通讯作者
(12) Yolk–shell nanostructured Fe3O4@C magnetic nanoparticles with enhanced peroxidase-like activity for label-free colorimetric detection of H2O2 and glucose, Nanoscale, 2017, 通讯作者
(13) Multiple-Armed Tetrahedral DNA Nanostructures for Tumor-Targeting, Dual-Modality in Vivo Imaging, ACS Appl. Mater. Interface, 2016, 通讯作者
(14) Constructing Higher-Order DNA Nanoarchitectures with Highly Purified DNA Nanocages, ACS Appl. Mater. Interface, 2015, 通讯作者
(15) Nanomaterial-Based Fluorescent DNA Analysis: A Comparative Study of the Quenching Effects of Graphene Oxide, Carbon Nanotubes, and Gold Nanoparticles, Adv Funct Mater , 2013, 通讯作者
(16) A power-free microfluidic chip for SNP genotyping using graphene oxide and a DNA intercalating dye, Chem Commun, 2013, 通讯作者
(17) A graphene oxide-based nano-beacon for DNA phosphorylation analysis. , Chemical Communications, 2011, 通讯作者
(18) A Graphene–Conjugated Oligomer Hybrid Probe for Light-Up Sensing of Lectin and Escherichia Coli, Advanced Materials, 2011, 第 1 作者
(19) Metal ion-modulated graphene-DNAzyme interactions: design of a nanoprobe for fluorescent detection of lead(II) ions with high sensitivity, selectivity and tunable dynamic range, Chemical Communication, 2011, 通讯作者
(20) Amplified Fluorescent Recognition of G-Quadruplex Folding with a Cationic Conjugated Polymer and DNA Intercalator. , Acs Applied Materials Interfaces, 2010, 通讯作者
(21) A graphene-enhanced molecular beacon for homogeneous DNA detection, Nanoscale, 2010, 通讯作者
(22) Gold nanoparticle-based sensing strategies for biomolecular detection, Pure Appl. Chem., 2010, 第 1 作者
(23) Mannose-Substituted Conjugated Polyelectrolyte and Oligomer as an Intelligent Energy Transfer Pair for Label-Free Visual Detection of Concanavalin A. , Macromolecules, 2010, 第 3 作者
(24) Biomolecular sensing via coupling DNA-based recognition with gold nanoparticles, J. Phys. D: Appl. Phys, 2010, 第 1 作者
(25) Aptamer-Based Multicolor Fluorescent Gold Nanoprobes for Multiplex Detection in Homogeneous Solution, Small, 2010, 第 2 作者
(26) A colorimetric strategy based on a water-soluble conjugated polymer for sensing pH-driven conformational conversion of DNA i-motif structure. , Biosensors Bioelectronics, 2010, 第 1 作者
(27) Amplified biosensing strategies for the detection of biologically related molecules with silica nanoparticles and conjugated polyelectrolytes , COSMOS, 2010, 第 1 作者
(28) Adenosine detection by using gold nanoparticles and designed aptamer sequences, Analyst, 2009, 通讯作者
(29) Ultrasonic-assisted synthesis and strepavidin conjugation of amino-magnetic nanoparticles. , Nuclear Science and Techniques, 2008, 通讯作者
(30) Visual cocaine detection with gold nanoparticles and rationally engineered aptamer structures. , Small, 2008, 第 2 作者
(31) Gold nanoparticle-based optical probes for target-responsive DNA structures., Gold Bull., 2008, 第 1 作者
(32) Aptamer-based biosensors. , Trends Anal. Chem., 2008, 第 2 作者
(33) A centrifugation-based method for preparation of gold nanoparticles and its application in biodetection., Int. J. Mol. Sci. , 2007, 通讯作者
(34) DNA hybridization turns on electrocatalysis at gold electrodes. , Chemical Communications, 2007, 第 2 作者
(35) A gold nanoparticle-based aptamer target binding readout for ATP assay., Advanced Materials , 2007, 第 1 作者
(36) A gold nanoparticle-based chronocoulometric DNA sensor for amplified detection of DNA. , Nature Protocols, 2007, 第 3 作者
(37) Unmodified gold nanoparticles as a colorimetric probe for potassium DNA aptamers. , Chemical Communications, 2006, 第 1 作者
(38) Effects of nanoparticle-mediated amplification and nanoscale control of DNA assembly at electrodes. , Journal of the American Chemical Society, 2006, 第 4 作者