Dunlop, Sarah - University of Western Australia

研究领域

Professor Sarah Dunlop leads an integrated program of laboratory and clinical research at The University of Western Australia & Royal Perth Hospital to promote functional recovery after traumatic injury to the nervous system. Laboratory studies use rodent models and focus on understanding and preventing the spread of secondary degeneration to intact tissue. Clinical studies comprise three multi-centre randomized controlled trials “Spinal Cord Injury and Physical Activity (SCIPA)” involving all 8 spinal units in Australia and New Zealand to examine novel ways to exercise the paralysed limbs to promote neurological recovery and improve health. The trials span acute care to the community, reflecting the lifetime need of these patients. SCIPA.Com has developeda program to train the trainers, break down barriers to exercise and increase participation once patients are living in the community. “ICED” Immediate Cooling and Early Decompression) is another multi-centre clinical initiative focusing on acute spinal cord injury involving immediate hypothermia in the ambulance to buy time and limit secondary damage before emergency surgical decompression. Another recent multi-centre initiative involves examining bladder care and urinary tract infections, a major secondary complication following spinal cord injury, to promote best practice for bladder care in Australia and New Zealand, Sarah is a past Director of the Spinal Cord Injury Network, a collaborative of clinicians, researchers and people living with spinal cord injury, and past Chair of its Clinical Trials Committee http://www.spinalnetwork.org.au

近期论文

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Harvey LA, Dunlop SA, Churilov L, (Hsueh, Y-S (A), Galea MP. (2011) Early intensive hand rehabilitation after spinal cord injury (“Hands On”): a protocol for a randomized controlled trial. BioMed Central Open Access. Trials. 12: 14-. Seitz M, Grosheva M, Skouras E, Angelova SK, Ankerne J, Jungnickel J, Grothe C, Klimaschewski L, Hübbers CU, Dunlop SA, Angelov DN. (2011) Poor functional recovery and muscle polyinnervation after facial nerve injury in fibroblast growth factor-2-/- mice can be improved by manual stimulation of denervated vibrissal muscles. Neuroscience182: 241-247. Ho D, Fitzgerald M, Bartlett C, Zdyrko B, Luzinov IA, Dunlop SA,* and K. Swaminathan Iyer*. (2011). The Effects of Concentration-Dependent Morphology of Self-assembling RADA16 Nanoscaffolds on Mixed Retinal Cultures. Nanoscale 3: 907-910. Payne SC, Bartlett, CA, Harvey AR, Dunlop SA, Fitzgerald M. (2011). Chronic swelling and abnormal myelination during secondary degeneration, following partial injury to a central nervous system tract. J. Neurotrauma. 8: 1077-1088. Bendella H, Pavlov, SP. Grosheva M, Maier S, AIrintchev A, Skouras E, Angelova SK, Merkel D, Sinis N, Kaidoglou K, Dunlop SA, Angelov DN (2011). Non-invasive stimulation of the vibrissal pad improves recovery of whisking function after simultaneous lesion of the facial and trigeminal nerves in rats. Experimental Brain Res 212: 65-79. Clemons TD, Evans CW, Zdyrko B, Luzinov I, Fitzgerald M, Dunlop SA, Harvey AR, Swaminathan Iyer K, * Stubbs KA* Multifunctional nanoadditives for the thermodynamic and kinetic stabilization of enzymes. Nanoscale 3: 4085-4087. Evans CW, Fitzgerald M, Clemons TD, House, MJ, Padman BS, Shaw JA, Saunders M, Harvey AR, Zdyrko B, Luzinov I. Silva GA, Dunlop SA, Iyer, KS. (2011) Multimodal Analysis of PEI-Mediated Endocytosis of Nanoparticles in Neural Cells" ACS Nano 5: 8640-8648. Roberton T, Romola S. Bucks, Timothy C. Skinner, Gary T. Allison, and Sarah A. Dunlop (2011). Barriers to Physical Activity in Individuals with Spinal Cord Injury: A West Australian Study. Australian Journal of Rehabilitation Counselling 17: 74-88. Wells J, Kilburn M, Shaw J, Bartlett C, Harvey A, Dunlop S, Fitzgerald. (2012) Early in vivo changes in calcium ions, oxidative stress markers and ion channel immunoreactivity following partial injury to the optic nerve. J Neuroscience Research 90: 606-618. Chai J, Vukovic J, Dunlop S, Grounds M, Shavlakadze T (2012) Striking denervation of neuromuscular junctions, without lumbar motoneuron loss, in geriatric mouse muscle. PloSONE 16: 12 e28090. Hizay A, Ozsoy U, Demirel BD, Ozsoy O, Angelova S, Ankerne J, Sarikcioglu SB, Dunlop SA, Angelov DN, Sarikcioglu L (2012) Use of a Y-Tube-Conduit Following Facial Nerve Injury Reduces Collateral Axonal Branching at the Lesion Site but Neither Reduces Polyinnervation of Motor Endplates nor Improves Functional Recovery. Neurosurgery 70: 1544-1556. Rodger J, Christina Mo, Tenelle Wilks, Sarah A Dunlop, Rachel M Sherrard (2012) Transcranial pulsed magnetic field stimulation facilitates reorganisation of abnormal neural circuits and corrects behavioural deficits without disrupting normal connectivity. FASEB 26:1593-1606. Harrison J, Bartlett CA, Cowin G, Nicholls PK, Evans CW, Clemons TD, Zdyrko B, Luzinov IA, Harvey AR, Swaminathan Iyer K, Dunlop SA, Fitzgerald M. In vivo Imaging and Biodistribution of Multimodal Polymeric Nanoparticles delivered to the Optic Nerve. Small DOI: 10.1002/Smll.20110264 Morellini N, Fear MW, Rea S, West AK, Wood FM, Dunlop SA. Burn injury has a systemic effect on reinnervation of skin and restoration of nociceptive function. Wound Repair and Regeneration. 20:367-377. Evans CW, Latter MJ, Ho D, Clemons TD, Fitzgerald M, Dunlop SA*, Swaminathan Iyer K* (2012) Multimodal and Multifunctional Stealth Block Copolymer Nanoparticles for Sustained Drug Delivery. New Journal of Chemistry 10.1039/c2nj40016b. Bates KA, Clark VW, Meloni BP, Dunlop SA, Rodger J. (2012) Short-term low intensity PMF does not improve functional or histological outcomes in a rat model of transient focal cerebral ischemia. Brain Research 1485:76-85. Ozsoy O, Ozsoy U, Stein G, Semler O, Skouras E, Schempf G, Wellmann K, Wirth F, Angelova S, Ankerne J, Ashrafi M, Schönau E, Papamitsou-Sidoropolou T, Jaminet P, Irintchev A, Dunlop SA#, Angelov DN# (Share equal last authorship). Functional deficits and morphological changes in the neurogenic bladder match the severity of spinal cord compression. Restorative Neurology and Neuroscience 30:363-381. Martin AD, Houlihan E, Morellini N, Eggers PK, James E, Stubbs KA, Harvey AR, Fitzgerald M, Raston CL, Dunlop SA. (2012) Synthesis and Toxicology of p-Phosphonic acid calixarenes and O-Alkylated Analogues as Potential Calixarene-based Phospholipids. ChemPlusChem, 2012 vol.77(4), 308-313. Payne SC, Bartlett CA, Harvey AR, Dunlop SA, Fitzgerald M. Myelin sheath decompaction, axon swelling and functional loss during chronic secondary degeneration in rat optic nerve. IOVS 53:6093-6101. Farid WO, Lawrence AJ, Krstew EV, Tait RJ, Hulse GK, Dunlop SA. (2012). Maternally administered sustained-release naltrexone in rats affects offspring neurochemistry and behaviour in adulthood. PLOS ONE 7: 12 e52812.