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个人简介

工作经历: 2018.09至今,浙江大学,航空航天学院,副教授 2011.08-2018.08,北京理工大学,宇航学院力学系,讲师、副教授 2012.06-2012.07,澳大利亚CSIRO-Computational and Simulation Sciences TCP,访问学者 教育经历: 2006.09-2011.07,北京,清华大学,航天航空学院,力学,博士 2002.09-2006.07,北京,清华大学,航天航空学院,力学,本科 主要从事分子生物力学方向研究,利用模拟和理论建模等手段并结合实验,定量揭示生物分子的动力学过程、结构与功能关系,实现对生物分子功能的预测和调控,并对重要疾病靶向治疗提供理论指导。包括:1.单分子力谱方法;2.生物分子的结构与功能关系;3.多尺度计算模型;4.纳米复合材料优化设计。 教学与课程 材料力学,本科生课程 2019-2020学年,春夏学期,64学时,39人 2018-2019学年,春夏学期,64学时,88人 2018.03-2018.07,72学时,北京理工大学,69人 2017.03-2017.07,80学时,北京理工大学,62人 2016.03-2016.07,40学时,北京理工大学,60人 2015.03-2015.07,40学时,北京理工大学,60人 2014.03-2014.07,40学时,北京理工大学,101人 2013.03-2013.07,16学时,北京理工大学,101人 2012.03-2012.07,16学时,北京理工大学,97人 力学科研训练II,本科生课程 2017.09-2017.09,4学时,北京理工大学,36人 2016.09-2016.09,4学时,北京理工大学,36人 2015.09-2015.09,4学时,北京理工大学,36人 2014.09-2014.09,4学时,北京理工大学,24人 2013.09-2013.09,4学时,北京理工大学,27人 2012.09-2012.09,4学时,北京理工大学,27人 分子动力学,研究生课程 2017.09-2018.01,32学时,北京理工大学,22人 2016.09-2017.01,32学时,北京理工大学,8人 2014.09-2015.01,36学时,北京理工大学,8人 2013.09-2014.01,36学时,北京理工大学,17人 2012.09-2013.12,36学时,北京理工大学,7人 Google Scholar主页链接:https://scholar.google.com/citations?user=YLyq21kAAAAJ&hl=en&oi=ao ResearcherID主页链接:http://www.researcherid.com/rid/D-2766-2009 ResearchGate主页链接:https://www.researchgate.net/profile/Dechang_Li 课题组成员 现有成员: 吴徐伟,水凝胶与皮肤相互作用的分子机制研究,硕士,2019.09至今,浙江大学。 沈文辉,丝蛋白结构与力学性能的分子动力学模拟研究,硕士,2018.09至今,北京理工大学。 已毕业学生: 梅乐,脂质膜与蛋白质和高分子聚合物相互作用机制研究,硕士,2017.09-2020.09,北京理工大学。毕业去向:中科信电子装备有限公司,北京。 马娟,树状分子穿越细胞膜运动机理分子动力学模拟研究,硕士,2015.09-2018.03,北京理工大学。毕业去向:元计算科技发展有限公司,北京。 刘杰,树形分子与细胞膜相互作用的分子动力学模拟研究,硕士,2014.09-2016.07,北京理工大学。毕业去向:北京理工大学博士研究生。 舒素云,光滑粒子流体动力学方法代码开发及其在冲击模拟中的应用,硕士,2013.09-2015.07,北京理工大学。毕业去向:北京航天奥祥通风科技有限公司,北京。 徐昌建,丝蛋白微观结构及简单层状复合材料破坏行为分子动力学模拟研究,硕士,2012.09-2015.03,北京理工大学。毕业去向:东风日产乘用车公司,广州。 招生招聘 研究生 课题组每年计划招收博士生、硕士生各一名,研究方向为分子力学,主要从事分子模拟与建模、纳米材料优化设计等研究。欢迎力学、物理、化学等专业学生报考。

研究领域

细胞与分子力学 生物材料的结构与力学行为

近期论文

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(*通讯作者): 40.Hung‐Chin Wu,Franziska Lissel,Ging‐Ji Nathan Wang,David M.Koshy,Shayla Nikzad,Hongping Yan,Jie Xu,Shaochuan Luo,Naoji Matsuhisa,Yuan Cheng,Fan Wang,Baohua Ji,Dechang Li,Wen‐Chang Chen,Gi Xue,Zhenan Bao*:Metal–Ligand Based Mechanophores Enhance Both Mechanical Robustness and Electronic Performance of Polymer Semiconductors.Advanced Functional Materials 2021; 39.Jie Liu,Bing Bu,Michael Crowe,Dechang Li*,Jiajie Diao*,Baohua Ji*:Membrane packing defects in synaptic vesicles recruit complexin and synuclein.Physical Chemistry Chemical Physics 2020; 38.Dechang Li,Qianchun Wang,Changjian Xu,Yuan Cheng,Yong-Wei Zhang,Baohua Ji*:How Does Nature Evade the“Larger is Weaker”Fate of Ultralong Silkβ-Sheet Nanocrystallites.Nano Letters 2020;20(12):8516-8523. 37.Le Mei,Wenhui Shen,Xuwei Wu,Jie Liu,Dechang Li*,Baohua Ji:Interactions of human islet amyloid polypeptide with lipid structure of different curvatures.Theoretical&Applied Mechanics Letters 2020;10(6):412-418. 36.Kai Wu,Dechang Li*,Peng Xiu*,Baohua Ji,Jiajie Diao*:O-GlcNAcylation inhibits the oligomerization of alpha-synuclein by declining intermolecular hydrogen bonds through a steric effect.Physical Biology 2020;18(1):016002. 35.Liang Pan,Pingqiang Cai,Le Mei,Yuan Cheng,Yi Zeng,Ming Wang,Ting Wang,Ying Jiang,Baohua Ji,Dechang Li*,Xiaodong Chen*:A Compliant Ionic Adhesive Electrode with Ultralow Bioelectronic Impedance.Advanced Materials 2020;2003723. 34.Bin Cai,Jie Liu,Yunfei Zhao,Xiangyu Xu,Bing Bu,Dechang Li*,Lei Zhang*,Wei Dong*,Baohua Ji,Jiajie Diao*:Single-vesicle imaging quantifies calcium’s regulation of nanoscale vesicle clustering mediated byα-synuclein.Microsystems&Nanoengineering 2020;6:38. 33.Fan Wang,Kui Liu,Dechang Li*,Baohua Ji*:Fracture toughness of biological composites with multi-level structural hierarchy.Journal of Applied Mechanics 2020;87(7):071004. 32.Fan Wang,Zhongzhong Cui,Dechang Li*,Baohua Ji*:Bidirectional regulation of configuration of the carbon nanotube containing a water droplet.Nanotechnology 2020;31:295603. 31.Liang Pan,Fan Wang,Yuan Cheng,Wan Ru Leow,Yong-Wei Zhang,Ming Wang,Pingqiang Cai,Baohua Ji,Dechang Li*,Xiaodong Chen*:A supertough electro-tendon based on spider silk composites.Nature Communications 2020;11:1332. 30.Dechang Li*,Baohua Ji*:Protein conformational transitions coupling with ligand interactions:simulations from molecules to medicine.Medicine in Novel Technology and Devices 12/2019;3:100026. 29.Zhiqi Tian,Jihong Gong,Michael Crowe,Ming Lei,Dechang Li*,Baohua Ji*,Jiajie Diao*:Biochemical studies of membrane fusion at the single-particle level.Progress in Lipid Research 01/2019;73:92-100. 28.Qianchun Wang,Xiaobo Zhai,Michael Crowe,Lu Gou,Yinfeng Li,Dechang Li*,Lei Zhang*,Jiajie Diao*,Baohua Ji*:Heterogeneous oxidization of graphene nanosheets damages membrane.Science China-Physics,Mechanics&Astronomy 01/2019;62(6):064611. 27.Xiaohang Zhou,Dechang Li*,Sijie Wan,Qunfeng Cheng,Baohua Ji*:In silicon testing of the mechanical properties of graphene oxide-silk nanocomposites.Acta Mechanica 04/2019;230:1413-1425. 26.Bing Bu,Michael Crowe,Jiajie Diao*,Baohua Ji*,Dechang Li*:Cholesterol suppresses membrane leakage by decreasing water penetrability.Soft Matter 05/2018;14:5277-5282. 25.Bing Bu,Xin Tong,Dechang Li*,Yachong Hu,Wangxiao He,Chunyu Zhao,Rui Hu,Xiaoqing Li,Yongping Shao,Cong Liu,Qing Zhao*,Baohua Ji*,Jiajie Diao*:N-Terminal Acetylation Preservesα-Synuclein from Oligomerization by Blocking Intermolecular Hydrogen Bonds.ACS Chemical Neuroscience 07/2017;8:2145-2151. 24.Sijie Wan,Qi Zhang,Xiaohang Zhou,Dechang Li,Baohua Ji,Lei Jiang,Qunfeng Cheng*:Fatigue Resistant Bioinspired Composite from Synergistic Two-Dimensional Nanocomponents.ACS Nano 06/2017;11:7074-7083. 23.Yuan Cheng,Leng-Duei Koh,Fan Wang,Dechang Li,Bahua Ji,Jingjie Yeo,Guijian Guan,Mingyong Han*,Yong-Wei Zhang*:Carbon Nanoscroll-Silk Crystallite Hybrid Structure with Controllable Hydration and Mechanical Properties.Nanoscale 06/2017;9:9181-9189. 22.Bing Bu,Dechang Li*,Jiajie Diao,Baohua Ji*:Mechanics of water pore formation in lipid Membrane under electric field.Acta Mechanica Sinica 02/2017;33(2):234-242. 21.Bing Bu,Zhiqi Tian,Dechang Li*,Baohua Ji*:High Transmembrane Voltage Raised by Close Contact Initiates Fusion Pore.Frontiers in Molecular Neuroscience 12/2016;9:136. 20.Dechang Li*,Ming S Liu*,Baohua Ji*:Mapping the Dynamics Landscape of Conformational Transitions in Enzyme:The Adenylate Kinase Case.Biophysical Journal 08/2015;109(3):647-660. 19.Zhongzhong Cui,Dechang Li*,Baohua Ji*:Effect of curvature on the behaviors of confined water layers.International Journal of Applied Mechanics 11/2015;7:1550084. 18.Yuan Cheng,Leng-Duei Koh,Dechang Li,Baohua Ji,Yingyan Zhang,Jingjie Yeo,Guijian Guan,Ming-Yong Han*,Yong-Wei Zhang*:Peptide-Graphene Interactions Enhance the Mechanical Properties of Silk Fibroin.ACS Applied Materials&Interfaces 09/2015;7:21787-21796. 17.Changjian Xu,Dechang Li*,Yuan Cheng,Ming Liu,Yongwei Zhang,Baohua Ji*:Pulling out a peptide chain fromβ-sheet crystallite:Propagation of instability of H-bonds under shear force.Acta Mechanica Sinica 05/2015;31:416-424. 16.Ying Lai,Lin Zhao,Bing Bu,Xiaochu Lou,Dechang Li,Baohua Ji,Jiankang Liu,Jiajie Diao*,Yeon-Kyun Shin*:Lipid molecules influence early stages of yeast SNARE-mediated membrane fusion.Physical Biology 04/2015;12:025003. 15.Xiaofeng Chen,Dechang Li,Baohua Ji,Bin Chen*:Reconciling bond strength of a slip bond at low loading rates with rebinding.EPL(Europhysics Letters)03/2015;109(6):68002. 14.Dechang Li*,Baohua Ji*:Crucial Roles of Bond Rebinding in Rupture Behaviors of Single Molecular Bond at Ultralow Loading Rates.International Journal of Applied Mechanics 02/2015;7(1):1550015. 13.Dechang Li,Baohua Ji*:Predicted Rupture Force of a Single Molecular Bond Becomes Rate Independent at Ultralow Loading Rates.Physical Review Letters 02/2014;112(7):078302. 12.Zhiyang Xu,Dechang Li*,Baohua Ji:Quantification of the stiffness and strength of cadherin ectodomain binding with different ions.Theoretical&Applied Mechanics Letters 05/2014;4(3):034001. 11.Yuan Cheng,Leng-Duei Koh,Dechang Li,Baohua Ji,Ming-Yong Han*,Yong-Wei Zhang*:On the strength ofβ-sheet crystallites of Bombyx mori silk fibroin.Journal of The Royal Society Interface 04/2014;11(96):20140305. 10.Dechang Li,Baohua Ji*:Free energy calculation of single molecular interaction using Jarzynski's identity method:The case of HIV-1 protease inhibitor system.Acta Mechanica Sinica 06/2012;28:891-903. 9.Dechang Li,Ming S Liu*,Baohua Ji*,Keh-Chih Hwang,Yonggang Huang*:Identifying the Molecular Mechanics and Binding Dynamics Characteristics of Potent Inhibitors to HIV-1 Protease.Chemical Biology&Drug Design 05/2012;80(3):440-454. 8.Ran Xu,Bin Liu*,Xiaoqiao He,Dechang Li:Kinetic Energy-Based Temperature Computation in Non-Equilibrium Molecular Dynamics Simulation.Journal of Computational and Theoretical Nanoscience 03/2012;9:428-433. 7.Dechang Li,Baohua Ji*,Keh-Chih Hwang,Yonggang Huang:Strength of Hydrogen Bond Network Takes Crucial Roles in the Dissociation Process of Inhibitors from the HIV-1 Protease Binding Pocket.PLoS ONE 04/2011;6:e19268. 6.Yuan Cheng*,Dechang Li,Baohua Ji,Xinghua Shi,Huajian Gao:Structure-based design of carbon nanotubes as HIV-1 protease inhibitors:Atomistic and coarse-grained simulations.Journal of molecular graphics&modelling 09/2010;29(2):171-177. 5.Dechang Li,Baohua Ji*,Kehchih Hwang,Yonggang Huang*:Crucial Roles of the Subnanosecond Local Dynamics of the Flap Tips in the Global Conformational Changes of HIV-1 Protease.The Journal of Physical Chemistry B 02/2010;114(8):3060-3069. 4.Dechang Li,Ming S Liu*,Baohua Ji*,Kehchih Hwang,Yonggang Huang*:Coarse-grained molecular dynamics of ligands binding into protein:The case of HIV-1 protease inhibitors.The Journal of Chemical Physics 07/2009;130(21):215102. 3.Dechang Li,Baohua Ji*,Kehchih Hwang,Yonggang Huang*:Coarse grained modeling of biopolymers and proteins:methods and applications.International Journal of Applied Mechanics 03/2009;01:113-136. 2.Dechang Li,Baohua Ji,Ming S.Liu,K.C.Hwang,Yonggang Huang:Coarse-grained Molecular Dynamics of Inhibitors Binding into HIV-1 Protease.In:Dössel O.,Schlegel W.C.(eds)World Congress on Medical Physics and Biomedical Engineering,September 7-12,2009,Munich,Germany.IFMBE Proceedings,vol 25/4.Springer,Berlin,Heidelberg 1.李德昌,季葆华*,黄永刚*,黄克智:生物大分子自组织坍塌行为的研究.医用生物力学01/2007;22(01):40-49.

学术兼职

中国力学学会固体力学专业委员会生物材料与仿生组组员(2020-) 世界华人生物医学工程协会(WACBE)青年委员(Young Scholar Committee)(2020-) Medicine in Novel Technology and Devices期刊编委 Review Editor: Frontiers in Neuroscience; 期刊审稿人 Briefings in Bioinformatics ACS Biomaterials Science & Engineering Journal of The Royal Society Interface Journal of Biomechanics Acta Mechanica Solida Sinica Materials Science & Engineering C Journal of Materials Science RSC Advances Frontiers in Neuroscience Journal of Applied Mechanics-ASME Frontiers in Molecular Neuroscience Chemical Biology & Drug Design Acta Mechanica Sinica Diamond and Related Materials Colloids and Surfaces A: Physicochemical and Engineering Aspects Scientific Reports Journal of Micromechanics and Molecular Physics International Journal of Computational Methods Interface focus: a theme supplement of Journal of the Royal Society interface Current Proteomics PeerJ PLoS ONE Advances in Civil Engineering

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