个人简介
吴禹,博士,浙江大学教授,博士生导师。现任浙江大学航空航天学院应用力学研究所副所长。在浙江大学工程力学系获得学士、博士学位,先后在美国田纳西大学、耶鲁大学从事博士后研究。2011年获耶鲁大学Rudolph Anderson Postdoctoral Fellowship,2019获浙江省杰出青年科学基金。通过随机动力学建模、计算与实验的有机结合,从基因、蛋白、细胞和信号调控网络等多尺度水平探索和揭示微环境在肿瘤产生发展中的机理。
教育背景
2003年9月-2008年6月,浙江大学,工程力学,博士
1999年9月-2003年6月,浙江大学,工程力学,学士
工作经历
2014年2月-至今,浙江大学,航空航天学院工程力学系,教授
2010年1月-2014年1月,美国耶鲁大学,生物医学工程系,博士后
2008年12月-2009年12月,美国田纳西大学,机械、航空航天与生物医学工程系,博士后
(招收上述研究方向的研究生和博士后,博士后薪酬12-26万元/年)
奖励或荣誉
耶鲁大学Rudolph Anderson Postdoctoral Fellowship 2011
浙江省151人才工程2015
浙江省杰出青年科学基金2019
教学与课程
本科生课程:工程力学(秋冬学期)
振动力学(秋冬学期)
研究生课程:非线性力学(冬学期)
实验室成员
在读研究生:
博士生
2015级:贾祥宇(硕博连读)
2016级:林楠(学科交叉培养直博)
2017级:周雨薇(直博)
2018级:化梦姣(普博)
硕士生
2018级:刘凯强
已毕业学生(去向)
陈逸安,2016年硕士毕业(中国商用飞机有限责任公司)
俞微,2017年硕士毕业(上海华力微电子有限公司)
雷灵宏,2017年硕士毕业(中国移动通信集团公司)
韩闯,2019年硕士毕业(南京景三医疗科技有限公司)
陈然,2020年硕士毕业(中国电子科技集团公司)
仪器设备
本实验室位于浙江大学玉泉校区教十二109和110房间,合计50余平方米,含近40平方米的千级超净间,共计购置设备60余台件,价值200余万元。已建成三个功能区块:微流控实验室、细胞生物学实验室和高通量荧光成像实验室。
一、微流控实验室
光刻机等离子清洗机
二、细胞生物学实验室
三、高通量荧光成像实验室
蔡司全电动活细胞荧光成像系统奥林巴斯全电动荧光显微镜
近期论文
查看导师新发文章
(温馨提示:请注意重名现象,建议点开原文通过作者单位确认)
27 X.Y.Jia and Y.Wu*,A brief introduction to epidemic dynamics modeling,Journal of Dynamics and Control(in Chinese),18(1):104-106(2020).
26 K.Q.Liu,M.J.Hua,N.Lin and Y.Wu*,Morphologically based cell classification in mixed cultures,Journal of Medical Biomechanics(in Chinese),34(2):153-159(2019).
25 R.Chen and Y.Wu*,Dynamics modeling and anti-drug resistance strategy analysis based on let7-LIN28 bistable phenomena,Journal of Medical Biomechanics(in Chinese),34(2):127-132(2019).
24 C.Han and Y.Wu*,A model of NSCLC microenvironment predicts optimal receptor targets,Quantitative Biology,7(2):147–161(2019).
23 X.Y.Jia and Y.Wu*,An Overview on the Interdisciplinary Studies of Dynamics and Life Sciences,Journal of Dynamics and Control(in Chinese),2017(3):279-288(2017).
22 W.Yu and Y.Wu*,A systematic analysis of intrinsic regulators for HIV-1 R5 to X4 phenotypic switch,Quantitative Biology,5(2):173-182(2017).
21 L.Mao,L.Shen,J.H.Chen,X.B.Zhang,M.Kwak,Y.Wu,R.Fan,L.Zhang,J.Pei,G.Y.Yuan,C.L.Song,J.B.Ge,and W.J.Ding,A promising biodegradable magnesium alloy suitable for clinical vascular stent application,Scientific Reports,7,46343(2017).
20 L.Mao,L.Shen,J.H.Chen,Y.Wu,M.Kwak,Y.Lu,Q,Xue,J.Pei,L.Zhang,G.Y.Yuan,R.Fan,J.B.Ge,and W.J.Ding,Enhanced Bioactivity of Mg−Nd−Zn−Zr Alloy Achieved with Nanoscale MgF2 Surface for Vascular Stent Application,ACS Applied Materials&Interfaces,7(9):5320-5330(2015).
19.L.Han,X.Y.Zi,L.X.Garmire,Y.Wu,S.M.Weissman,X.H.Pan,and R.Fan,Co-detection and sequencing of genes and transcripts from the same single cells facilitated by a microfluidics platform,Scientific Reports,4:6485(2014).
18.M.Kwak,D.J.Kim,M.R.Lee,Y.Wu,L.Han,S.K.Lee,and R.Fan,Nanowire array chips for molecular typing of rare trafficking leukocytes with application to neurodegenerative pathology,Nanoscale,6(12):6537-6550(2014).
This article was highlighted on the cover of the issue in which it appeared.
17.S.Jonas,E.Zhou,E.Deniz,B.Huang,K.Chandrasekera,D.Bhattacharya,Y.Wu,R.Fan,T.M.Deserno,M.K.Khokha,and M.A.Choma,A novel approach to quantifying ciliary physiology:microfluidic mixing driven by a ciliated biological surface,Lab on a Chip,13:4160-4163(2013).
16.L.Mao,L.Shen,J.L.Niu,J.Zhang,W.J.Ding,Y.Wu,R.Fan,and G.Y.Yuan,Nanophasic biodegradation enhances the durability and biocompatibility of magnesium alloys for the next-generation vascular stents,Nanoscale,5:9517-9522(2013)
15.M.Kwak,L.Mu,Y.Lu,J.J.Chen,Y.Wu,K.Brower,and R.Fan,Single-cell protein secretomic signatures as potential correlates to tumor cell lineage evolution and cell-cell interaction,Frontiers in oncology,3:10(2013).
14.Y.Lu,J.J.Chen,L.Mu,Q.Xue,Y.Wu,P.H.Wu,K.Miller-Jensen,D.Wirtz,and R.Fan,High-throughput secretomic analysis of single cells to assess functional cellular heterogeneity,Analytical Chemistry,85(4):2548–2556(2013).
13.Y.Wu,Y.Lu,W.Q.Chen,J.P.Fu,and R.Fan,In silico experimentation of glioma microenvironment development and anti-tumor therapy,PLoS Computational Biology,8(2):e1002355(2012).
12.J.Zhou*,Y.Wu*,S.K.Lee,and R.Fan,High-content single-cell analysis on-chip using a laser microarray scanner,Lab on a Chip,12(23):5025-5033(2012).(*equal contribution)
11.Y.Wu,L.X.Garmire,and R.Fan,Inter-cellular signaling network reveals a mechanistic transition in tumor microenvironment,Integrative Biology,4:1478-1486(2012).
10.S.K.Lee,G.S.Kim,Y.Wu,D.J.Kim,Y.Lu,M.Kwak,L.Han,J.H.Hyung,J.K.Seol,C.Sander,A.Gonzalez,J.Li and R.Fan,Nanowire substrate-based laser scanning cytometry for quantitation of circulating tumor cells,Nano Letters,12(6):2697-2704(2012).
9.D.J.Kim,J.K.Seol,Y.Wu,S.Ji,G.S.Kim,J.H.Hyung,S.Y.Lee,H.Lim,R.Fan,and S.K.Lee,A quartz nanopillar hemocytometer for high-yield separation and counting of CD4+T lymphocytes,Nanoscale,4(7):2500-2507(2012).
This article was highlighted on the cover of the issue in which it appeared.
8.Y.Wu,M.J.Zhang,J.Wu,X.P.Zhao,and L.J.Xia,Evolutionary game theoretic strategy for optimal drug delivery to influence selection pressure in treatment of HIV-1.Journal of Mathematical Biology,64(3):495-512(2012).
7.Y.Wu,X.P.Zhao,and M.J.Zhang,Dynamics of stochastic mutation to immunodominance.Mathematical Biosciences and Engineering,9(4):937-952(2012).
6.L.J.Xia,S.C.Lenaghan,M.J.Zhang,Y.Wu,X.P.Zhao,J.N.Burris,and C.N.Stewart Jr,Characterization of English ivy(Hedera helix)adhesion force and imaging using atomic force microscopy.Journal of Nanoparticle Research,13:1029-1037(2011).
5.Y.Wu,L.J.Xia,M.J.Zhang,and X.P.Zhao,Immunodominance analysis through interactions of CD8+T cells and DCs in lymph nodes.Mathematical Biosciences,225:53-58(2010).
4.Y.Wu,X.P.Zhao,and M.J.Zhang,Adhesion mechanics of ivy nanoparticles.Journal of Colloid and Interface Science,344:533-540(2010).
3.Y.Wu and W.Q.Zhu,Stationary response of multi-degree-of-freedom vibro-impact systems to Poisson white noises.Physics Letters A,372:623-630(2008).
2.Y.Wu and W.Q.Zhu,Stationary response of MDOF dissipated Hamiltonian systems to Poisson white noises.ASME Journal of Applied Mechanics,75:044502(2008).
1.Y.Wu and W.Q.Zhu,Stochastic analysis of a pulse-type prey-predator model,Physical Review E,77:041911(2008).