Tuckey, Robert - University of Western Australia - School of Chemistry and Biochemistry

研究领域

Current research involves structure-function studies on cytochrome P450scc, regulation of progesterone synthesis in the human placenta, cholesterol transport for steroid synthesis, and metabolism of vitamins D2 and D3 and their precursors by cytochrome P450scc.

近期论文

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1.Slominski, A., Semak, I., Wortsman, J., Zjawiony, J., Li, W., Zbytek, B. and Tuckey, R.C. An alternate pathway of vitamin D2 metabolism: Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2, The FEBS Journal, in press (2006) 2.Slominski, A., Semak, I., Zjawiony, J., Wortsman, J., Gandy, M.N., Li, J., Zbytek, B., Li, W. and Tuckey, R.C. Enzymatic Metabolism of Ergosterol by Cytochrome P450scc to Biologically Active 17α, 24-Dihydroxyergosterol, Chemistry & Biology, 12: pp 931-939 (2005) 3.Slominski, A., Semak, I., Zjawiony, J., Wortsman, J., Wei, L., Szczesniewski, A. and Tuckey, R.C. The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism, The FEBS Journal, 272 : pp 4080-4090 (2005) 4.Tuckey, R.C. Progesterone Synthesis by the Human Placenta, Placenta, 26: pp 273-281 (Review) (2005) 5.Slominski, A., Zjawiony, J., Wortsman, J., Semak, I., Stewart, J., Pisarchik, A., Sweatman, T., Marcos, J., Dunbar, C. and Tuckey, R.C. A novel pathway for sequential transformation of 7-dehydrocholesterol and expression of the P450scc system in mammalian skin, European Journal of Biochemistry, 271: pp 4178-4188 (2004) 6.Tuckey, R.C., Bose, H., Czerwionka, I. and Miller, W.L. Molten Globule Structure and Steroidogenic Activity of N-218 MLN64 in Human Placental Mitochondria, Endocrinology, 145:4, pp 1700-1707 (2004) 7.Johnson, D., Norman, S., Tuckey, R.C. and Martin, L.L. Electrochemical behaviour of human adrenodoxin on a pyrolytic graphite electrode, Bioelectrochemistry, 59: pp 41-47 (2003) 8.Headlam, M.J., Wilce, M.C. and Tuckey, R.C. The F-G loop region of cytochrome P450scc (CYP11A1) interacts with the phospholipid membrane, Biochimica et Biophysica Acta, 1617: pp 96-108 (2003) 9.Tuckey, R.C., Headlam, M.J., Bose, H.S. and Miller, W.L. Transfer of Cholesterol between Phospholipid Vesicles Mediated by the Steroidogenic Acute Regulatory Protein (StAR), The Journal of Biological Chemistry, 277:49, December 06, pp 47123-47128 (2002) 10.Tuckey, R.C. and Headlam, M.J. Placental cytochrome P450scc (CYP11A1): comparison of catalytic properties between conditions of limiting and saturating adrenodoxin reductase, Journal of Steroid Biochemistry and Molecular Biology, 81: pp 153-158 (2002) 11.Headlam, M.J. and Tuckey, R.C. The effect of glycerol on cytochrome P450scc (CYP11A1) spin state, activity, and hydration, Archives of Biochemistry and Biophysics, 407: pp 95-102 (2002) 12.Tuckey, R.C., McKinley, A.J. and Headlam, M.J. Oxidized adrenodoxin acts as a competitive inhibitor of cytochrome P450scc in mitochondria from the human placenta, European Journal of Biochemistry, 268: pp 2338-2343 (2001) 13.Tuckey, R. C. McKinley, A. and Sadleir, J. "Adrenodoxin Reductase Limits Cytochrome P450scc Activity in the Human Placenta" in Molecular Steroidogenesis, (Okamoto, M., Ishimura, Y. and Nawata, H. eds) pp 119-120 (2000). Universal Academy Press, Tokyo. 14.Tuckey, R. C. and Sadleir, J. The Concentration of Adrenodoxin Reductase Limits Cytochrome P450scc Activity in the Human Placenta. Eur. J. Biochem. 263: pp 319-325 (1999) 15.Kisselev, P., Tuckey, R. C., Woods, S., Triantopolous, T. and Schwarz, D. Enzymatic properties of Vesicle-Reconstituted Human Cytochrome P450scc (CYP11A1). Differences in Functioning of the Mitochondrial Electron Transfer Chain using Human and Bovine Adrenodoxin and Activation by Cardiolipin. Eur. J. Biochem. 260: pp 768-773 (1999) 16.Woods, S. T., Sadleir, J., Downs, T., Triantopoulos, T., Headlam, M. J. and Tuckey, R. C. Expression of Catalytically Active Human Cytochrome P450scc in Escherichia coli and Mutagenesis of Isoleucine-462. Arch. Biochem. Biophys. 353: pp 109-115 (1998) 17.Glencross, B., Mullan, B. P., Tuckey, R. C. and Hartmann, P. E. A Simplification of the Deuterium Oxide Dilution Technique using FT-IR Analysis of Plasma, for Estimating Piglet Milk Intake. Aust. J. Agric. Res. 48: pp 1099-1104 (1997) 18.Tuckey, R. C., Woods, S. T. and Tajbakhsh, M. Electron Transfer to Cytochrome P-450scc Limits Cholesterol Side-Chain-Cleavage Activity in the Human Placenta. Eur. J. Biochem. 244: pp 835-839 (1997) 19.Tuckey, R. C., Lawrence, J. and Cameron, K. J. Side Chain Cleavage of Cholesterol Esters by Human Cytochrome P-450scc. J. Steroid. Biochem. Mol. Biol. 58: pp 605-610 (1996) 20.Jennings, G. J., Sechi, S., Stevenson, P. M., Tuckey, R. C., Parmellee, D. and Mcalister-Henn, L. Cytoplasmic NADP+-Dependent Isocitrare Dehydrogenase: Isolation of Rat cDNA and Study of the Tissue Specific and Developmental Expression of mRNA. J. Biol. Chem. 269: pp 23128-23134 (1994)