Scaffidi, Adrian - University of Western Australia - School of Chemistry and Biochemistry

研究领域

Karrikins are a new class of germination stimulants present in smoke that have attracted significant interest due to their ability to promote the germination of species present in both fire and non-fire prone regions at remarkably low concentrations. Karrikins provide an opportunity for improving the restoration of natural and disturbed ecosystems by increasing the germination rate of various species, in addition to plant conservation and weed control. My research aims to further understand the role of karrikins in Nature by investigating their metabolism, molecular targets and environmental fate. Collaborators Assoc. Prof. Gavin Flematti, Chemistry, UWA Asst. Prof. David Nelson, University of Georgia, USA Dr David Merritt, Kings Park and Botanical Garden Prof. Christine Beveridge, School of Biological Sciences, UQ

近期论文

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Scaffidi, A., Algar, D., Bohman, B., Ghisalberti, E.L., Flematti, G. 2016, 'Identification of the Cat Attractants Isodihydronepetalactone and Isoiridomyrmecin from Acalypha indica', Australian Journal of Chemistry, 69, 2, pp. 169-173. Detail Flematti, G.R., Scaffidi, A., Waters, M.T., Smith, S.M. 2016, 'Stereospecificity in strigolactone biosynthesis and perception', Planta, 243, 6, pp. 1361-1373. Detail Brewer, P.B., Yoneyama, K., Filardo, F., Meyers, E., Scaffidi, A., Frickey, T., Akiyama, K., Seto, Y., Dun, E.A., Cremer, J.E., Kerr, S.C., Waters, M.T., Flematti, G.R., Mason, M.G., Weiller, G., Yamaguchi, S., Nomura, T., Smith, S.M., Beveridge, C.A. 2016, 'Lateral branching oxidoreductase acts in the final stages of strigolactone biosynthesis in Arabidopsis', Proceedings of the National Academy of Sciences of the United States of America, 113, 22, pp. 6301-6306. Detail Waters, M.T., Scaffidi, A., Moulin, S.L.Y., Sun, Y.K., Flematti, G.R., Smith, S.M. 2015, 'A selaginella moellendorffii ortholog of KARRIKIN INSENSITIVE2 functions in arabidopsis development but cannot mediate responses to karrikins or strigolactones', Plant Cell, 27, 7, pp. 1925-1944. Detail Zhao, L.H., Zhou, X.E., Yi, W., Wu, Z., Liu, Y., Kang, Y., Hou, L., De Waal, P.W., Li, S., Jiang, Y., Scaffidi, A., Flematti, G.R., Smith, S.M., Lam, V.Q., Griffin, P.R., Wang, Y., Li, J., Melcher, K., Xu, H.E. 2015, 'Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3', Cell Research, 25, 11, pp. 1219-1236. Detail Waters, M.T., Scaffidi, A., Flematti, G.R., Smith, S.M. 2015, 'Substrate-Induced Degradation of the α/β-Fold Hydrolase KARRIKIN INSENSITIVE2 Requires a Functional Catalytic Triad but Is Independent of MAX2', MOLECULAR PLANT, 8, 5, pp. 814-817. Detail Scaffidi, A., Waters, M.T., Sun, Y.K., Skelton, B.W., Dixon, K.W., Ghisalberti, E.L., Flematti, G.R., Smith, S.M. 2014, 'Strigolactone hormones and their stereoisomers signal through two related receptor proteins to induce different physiological responses in arabidopsis', Plant Physiology, 165, 3, pp. 1221-1232. Detail Waters, M.T., Scaffidi, A., Sun, Y.K., Flematti, G.R., Smith, S.M. 2014, 'The karrikin response system of Arabidopsis', Plant Journal, 79, 4, pp. 623-631. Detail Zhang, Y., van Dijk, A.D.J., Scaffidi, A., Flematti, G.R., Hofmann, M., Charnikhova, T., Verstappen, F., Hepworth, J., van der Krol, S., Leyser, O., Smith, S.M., Zwanenburg, B., Al-Babili, S., Ruyter-Spira, C., Bouwmeester, H.J. 2014, 'Rice cytochrome P450 MAX1 homologs catalyze distinct steps in strigolactone biosynthesis', NATURE CHEMICAL BIOLOGY, 10, 12, pp. 1028-1033. Detail Flematti, G.R., Waters, M.T., Scaffidi, A., Merritt, D.J., Ghisalberti, E.L., Dixon, K.W., Smith, S.M. 2013, 'Karrikin and Cyanohydrin Smoke Signals Provide Clues to New Endogenous Plant Signalling Compounds', MOLECULAR PLANT, 6, 1, pp. 29-37. Detail Bythell-Douglas, R., Waters, M.T., Scaffidi, A., Flematti, G.R., Smith, S.M., Bond, C.S. 2013, 'The Structure of the Karrikin-Insensitive Protein (KAI2) in Arabidopsis thaliana', PLoS ONE, 8, 1, pp. 1-8. Detail Scaffidi, A., Waters, M.T., Ghisalberti, E.L., Dixon, K.W., Flematti, G.R., Smith, S.M. 2013, 'Carlactone-independent seedling morphogenesis in Arabidopsis', Plant Journal, 76, 1, pp. 9pp. Detail Waters, M.T., Scaffidi, A., Flematti, G.R., Smith, S.M. 2013, 'The origins and mechanisms of karrikin signalling', Current Opinion in Plant Biology, 16, pp. 667-673. Detail Boulos, R.A., Eroglu, E., Chen, X., Scaffidi, A., Edwards, B.R., Toster, J., Raston, C.L. 2013, 'Unravelling the structure and function of human hair', Green Chemistry, 15, pp. 1268-1273. Detail Scaffidi, A., Waters, M.T., Bond, C.S., Dixon, K.W., Smith, S.M., Ghisalberti, E.L., Flematti, G.R. 2012, 'Exploring the molecular mechanism of karrikins and strigolactones', BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22, 11, pp. 3743-3746. Detail Scaffidi, A., Waters, M.T., Skelton, B.W., Bond, C.S., Sobolev, A.N., Bythell-Douglas, R., McKinley, A.J., Dixon, K.W., Ghisalberti, E.L., Smith, S.M., Flematti, G.R. 2012, 'Solar irradiation of the seed germination stimulant karrikinolide produces two novel head-to-head cage dimers', ORGANIC & BIOMOLECULAR CHEMISTRY, 10, pp. 4069-4073. Detail Waters, M.T., Nelson, D.C., Scaffidi, A., Flematti, G.R., Sun, Y., Dixon, K.W., Smith, S.M. 2012, 'Specialisation within the DWARF14 protein family confers distinct responses to karrikins and strigolactones in Arabidopsis', Development, 139, pp. 1285-1295. Detail Waters, M.T., Scaffidi, A., Flematti, G.R., Smith, S.M. 2012, 'Karrikins force a rethink of strigolactone mode of action', PLANT SIGNALING AND BEHAVIOR, 7, 8, pp. 969-972. Detail SCAFFIDI, A., FLEMATTI, G.R., NELSON, D., DIXON, K.W., SMITH, S.M., GHISALBERTI, E.L. 2011, 'The synthesis and biological evaluation of labelled karrikinolides for the elucidation of the mode of action of the seed germination stimulant', Tetrahedron, 67, pp. 152-157. Detail Nelson, D., Scaffidi, A., Dun, EA, Waters, M.T., Flematti, G.R., Dixon, K.W., Beveridge, CA, Ghisalberti, E.L., Smith, S.M. 2011, 'F-box protein MAX2 has dual roles in karrikin and strigolactone signaling in Arabidopsis thaliana', PNAS, 108, pp. 8897-8902. Detail