Lai, Ching Tat - University of Western Australia - School of Chemistry and Biochemistry

研究领域

Dr Lai's overall research is on milk production and the physiology of breast feeding, but he is currently researching expression regimes and milk production over time for pre-term babies. There are an increasing number of pre-term babies being born, and with medical advances a greater number of pre-term babies are able to survive, however the appropriate nutrition for these babies remains unknown. A pre-term baby has a very different nutritional environment to a fetus of the same age, which will still be receiving all its nutrition via the placenta. The effects of this change on pre-term babies are not yet known, but it is suspected that breast milk is extremely important for them. The exact composition of breastmilk varies between individual mothers and has an extremely complex composition which consists of a lot of biologically active compounds that help with growth and development.

近期论文

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Alsaweed, M., Lai, C.T., Hartmann, P.E., Geddes, D.T., Kakulas, F. 2016, 'Human milk miRNAs primarily originate from the mammary gland resulting in unique miRNA profiles of fractionated milk', Scientific Reports, 6, Detail Trend, S.E., Strunk, T., Lloyd, M.L., Kok, Y., Metcalfe, J., Geddes, D.T., Lai, C.T., Richmond, P.C., Doherty, D.A., Simmer, K.N., Currie, A.J. 2016, 'Levels of innate immune factors in preterm and term mothers’ breast milk during the 1st month postpartum', BRITISH JOURNAL OF NUTRITION, 115, 7, pp. 1178-1193. Detail Cannon, A.M., Sakalidis, V.S., Lai, C.T., Perrella, S.L., Geddes, D.T. 2016, 'Vacuum characteristics of the sucking cycle and relationships with milk removal from the breast in term infants', Early Human Development, 96, pp. 1-6. Detail Alsaweed, M., Lai, C.T., Hartmann, P.E., Geddes, D.T., Kakulas, F. 2016, 'Human milk cells and lipids conserve numerous known and novel miRNAs, some of which are differentially expressed during lactation', PLoS ONE, 11, 4, Detail Alsaweed, M., Lai, C.T., Hartmann, P.E., Geddes, D.T., Kakulas, F. 2016, 'Human milk cells contain numerous miRNAs that may change with milk removal and regulate multiple physiological processes', International Journal of Molecular Sciences, 17, 6, Detail Gardner, H., Kent, J.C., Lai, C.T., Mitoulas, L.R., Cregan, M.D., Hartmann, P.E., Geddes, D.T. 2015, 'Milk ejection patterns: An intra- individual comparison of breastfeeding and pumping', BMC PREGNANCY AND CHILDBIRTH, 15, 1, pp. 1-6. Detail Perrella, S.L., Lai, C.T., Geddes, D.T. 2015, 'Case report of nipple shield trauma associated with breastfeeding an infant with high intra-oral vacuum', BMC PREGNANCY AND CHILDBIRTH, 15, 1, pp. Article 155. Detail Cannon, A.M., Kakulas, F., Hepworth, A.R., Lai, C.T., Hartmann, P.E., Geddes, D.T. 2015, 'The effects of leptin on breastfeeding behaviour', International Journal of Environmental Research and Public Health, 12, 10, pp. 12340-12355. Detail Zhang, G., Lai, C.T., Hartmann, P.E., Oddy, W.H., Kusel, M.M.H., Sly, P.D., Holt, P.G. 2014, 'Anti-infective proteins in breast milk and asthma-associated phenotypes during early childhood', Pediatric Allergy and Immunology, 25, 6, pp. 544-551. Detail Arthur, P.G., Niu, X.-W., Huang, W.-H., DeBoer, B., Lai, C.T., Rossi, E., Joseph, J., Jeffrey, G.P. 2013, 'Desferrioxamine in warm reperfusion media decreases liver injury aggravated by cold storage', World Journal of Gastroenterology, 19, 5, pp. 673-681. Detail Hassiotou, F., Hepworth, A.R., Williams, T.M., Twigger, A.-J., Perrella, S., Lai, C.T., Filgueira, L., Geddes, D.T., Hartmann, P.E. 2013, 'Breastmilk Cell and Fat Contents Respond Similarly to Removal of Breastmilk by the Infant', PLOS ONE, 8, pp. 11pp. Detail Christen, L., Lai, C. T., Hartmann, B., Hartmann, P.E., Geddes, D.T. 2013, 'Ultraviolet-C Irradiation: A Novel Pasteurization Method for Donor Human Milk', PLOS ONE, 8, 6, pp. 7pp. Detail Khan, S., Prime, D.K., Hepworth, A.R., Lai, C.T., Trengove, N.J., Hartmann, P.E. 2013, 'Investigation of short-term variations in term breast milk composition during repeated breast expression sessions', JOURNAL OF HUMAN LACTATION, 29, 2, pp. 196-204. Detail Christen, L., Lai, C.T., Hartmann, B.T., Hartmann, P.E., Geddes, D.T. 2013, 'The Effect of UV-C Pasteurization on Bacteriostatic Properties and Immunological Proteins of Donor Human Milk', PLOS ONE, 8, 12, pp. 9pp. Detail Hassiotou, F., Hepworth, A.R., Metzger, P., Lai, C.T., Trengove, N., Hartmann, P.E., Filgueira, L. 2013, 'Maternal and infant infections stimulate a rapid leukocyte response in breastmilk', Clinical & Translational Immunology, 2, 4, pp. 10pp. Detail Geddes, D.T., Sakalidis, V.S., Hepworth, A.R., McClellan, H.L., Kent, J.C., Lai, C.T., Hartmann, P.E. 2012, 'Tongue movement and intra-oral vacuum of term infants during breastfeeding and feeding from an experimental teat that released milk under vacuum only', Early Human Development, 88, pp. 443-449. Detail Hassiotou, F., Beltran, A, Chetwynd, E, Stuebe, AM, Twigger, A., Metzger, P, Trengrove, N, Lai, C.T., Filgueira, L., Blancafort, P., Hartmann, P.E. 2012, 'Breastmilk is a novel source of stem cells with multilineage differentiation potential', STEM CELLS, 30, pp. 2164-2174. Detail Morton, J., Wong, R.J., Hall, J.Y., Pang, W.W., Lai, C.T., Lui, J., Hartmann, P.E., Rhine, W.D. 2012, 'Combining hand techniques with electric pumping increases the caloric content of milk in mothers of preterm infants', Journal of Perinatology, 32, pp. 1-6. Detail Khan, S., Hepworth, A.R., Prime, D.K., Lai, C.T., Trengove, N.J., Hartmann, P.E. 2012, 'Variation in Fat, Lactose, and Protein Composition in Breast Milk over 24 Hours: Associations with Infant Feeding Patterns', JOURNAL OF HUMAN LACTATION, 2013, pp. 1–9. Detail Sakalidis, V., McClellan, H.L., Hepworth, A.R., Kent, J.C., Lai, C.T., Hartmann, P.E., Geddes, D.T. 2012, 'Oxygen Saturation and Suck-Swallow-Breathe Coordination of Term Infants during Breastfeeding and Feeding froma Teat Releasing Milk Only with Vacuum', International Journal of Pediatrics, 2013, pp. 1-10. Detail