Flematti, Gavin - University of Western Australia - School of Chemistry and Biochemistry

研究领域

Natural Products and Chemical Ecology The primary research interest in the Flematti Lab is the isolation and identification of bioactive natural products. The specific activity of these compounds ranges from antibacterial and anticancer activity, through to organism defence and chemical communication. As well as traditional natural product extraction and isolation, we make use of sophisticated analytical instruments including HPLC, GC-MS, HPLC-MS and more recently GC-EAD/MS, to aid in the detection and isolation of bioactive compounds, which are characterised using NMR spectroscopy and high resolution MS techniques. Depending on the structure and function, interesting compounds are confirmed through chemical synthesis.

近期论文

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Scaffidi, A., Algar, D., Bohman, B., Ghisalberti, E.L., Flematti, G. 2016, 'Identification of the Cat Attractants Isodihydronepetalactone and Isoiridomyrmecin from Acalypha indica', Australian Journal of Chemistry, 69, 2, pp. 169-173. Detail Banik, B.K., Durmic, Z., Erskine, W., Revell, C.K., Vadhanabhuti, J., McSweeney, C.S., Padmanabha, J., Flematti, G.R., Algreiby, A., Vercoe, P.E. 2016, 'Bioactive fractions from the pasture legume Biserrula pelecinus L. have an anti-methanogenic effect against key rumen methanogens', Anaerobe, 39, pp. 173-182. Detail Newson, H.L., Wild, D.A., Yeung, S.Y., Skelton, B.W., Flematti, G.R., Allan, J.E., Piggott, M.J. 2016, 'Access to 1,2,3,4-Tetraoxygenated Benzenes via a Double Baeyer-Villiger Reaction of Quinizarin Dimethyl Ether: Application to the Synthesis of Bioactive Natural Products from Antrodia camphorata', Journal of Organic Chemistry, 81, 8, pp. 3127-3135. Detail Flematti, G.R., Scaffidi, A., Waters, M.T., Smith, S.M. 2016, 'Stereospecificity in strigolactone biosynthesis and perception', Planta, 243, 6, pp. 1361-1373. Detail Brewer, P.B., Yoneyama, K., Filardo, F., Meyers, E., Scaffidi, A., Frickey, T., Akiyama, K., Seto, Y., Dun, E.A., Cremer, J.E., Kerr, S.C., Waters, M.T., Flematti, G.R., Mason, M.G., Weiller, G., Yamaguchi, S., Nomura, T., Smith, S.M., Beveridge, C.A. 2016, 'Lateral branching oxidoreductase acts in the final stages of strigolactone biosynthesis in Arabidopsis', Proceedings of the National Academy of Sciences of the United States of America, 113, 22, pp. 6301-6306. Detail Kochanek, J., Long, R.L., Lisle, A.T., Flematti, G.R. 2016, 'Karrikins identified in biochars indicate post-fire chemical cues can influence community diversity and plant development', PLoS ONE, 11, 8, Detail Ho, L.A., Thomas, E., McLaughlin, R.A., Flematti, G.R., Fuller, R.O. 2016, 'A new selective fluorescent probe based on tamoxifen', Bioorganic and Medicinal Chemistry Letters, 26, 20, pp. 4879-4883. Detail Bythell-Douglas, R., Suttisansanee, U., Flematti, G.R., Challenor, M., Lee, M., Panjikar, S.K., Honek, J.F., Bond, C.S. 2015, 'The crystal structure of a homodimeric Pseudomonas glyoxalase I enzyme reveals asymmetric metallation commensurate with half-of-sites activity', CHEMISTRY-A EUROPEAN JOURNAL, 21, 2, pp. 541-544. Detail Bohman, B., Flematti, G.R. 2015, 'Oxidation of hydroxymethylpyrazines and hydroxylated phenyl compounds in a gas chromatography inlet', Analytical Methods, 7, 6, pp. 2283-2286. Detail Waters, M.T., Scaffidi, A., Moulin, S.L.Y., Sun, Y.K., Flematti, G.R., Smith, S.M. 2015, 'A selaginella moellendorffii ortholog of KARRIKIN INSENSITIVE2 functions in arabidopsis development but cannot mediate responses to karrikins or strigolactones', Plant Cell, 27, 7, pp. 1925-1944. Detail Bohman, B., Flematti, G.R., Barrow, R.A. 2015, 'Identification of hydroxymethylpyrazines using mass spectrometry', Journal of Mass Spectrometry, 50, 8, pp. 987-993. Detail Zhao, L.H., Zhou, X.E., Yi, W., Wu, Z., Liu, Y., Kang, Y., Hou, L., De Waal, P.W., Li, S., Jiang, Y., Scaffidi, A., Flematti, G.R., Smith, S.M., Lam, V.Q., Griffin, P.R., Wang, Y., Li, J., Melcher, K., Xu, H.E. 2015, 'Destabilization of strigolactone receptor DWARF14 by binding of ligand and E3-ligase signaling effector DWARF3', Cell Research, 25, 11, pp. 1219-1236. Detail Waters, M.T., Scaffidi, A., Flematti, G.R., Smith, S.M. 2015, 'Substrate-Induced Degradation of the α/β-Fold Hydrolase KARRIKIN INSENSITIVE2 Requires a Functional Catalytic Triad but Is Independent of MAX2', MOLECULAR PLANT, 8, 5, pp. 814-817. Detail Linthorne, J., Chang, B.J., Flematti, G.R., Ghisalberti, E.L., Sutton, D.C. 2015, 'A Direct Pre-screen for Marine Bacteria Producing Compounds Inhibiting Quorum Sensing Reveals Diverse Planktonic Bacteria that are Bioactive', MARINE BIOTECHNOLOGY, 17, pp. 33-42. Detail Zhang, Y., van Dijk, A.D.J., Scaffidi, A., Flematti, G.R., Hofmann, M., Charnikhova, T., Verstappen, F., Hepworth, J., van der Krol, S., Leyser, O., Smith, S.M., Zwanenburg, B., Al-Babili, S., Ruyter-Spira, C., Bouwmeester, H.J. 2014, 'Rice cytochrome P450 MAX1 homologs catalyze distinct steps in strigolactone biosynthesis', NATURE CHEMICAL BIOLOGY, 10, 12, pp. 1028-1033. Detail Paczkowski, S., Paczkowska, M., Dippel, S., Flematti, G.R., Schütz, S. 2014, 'Volatile Combustion Products of Wood Attract Acanthocnemus nigricans (Coleoptera: Acanthocnemidae)', Journal of Insect Behavior, 27, 2, pp. 228-238. Detail Buccini, M., Punch, K.A., Kaskow, B.J., Flematti, G.R., Skelton, B.W., Abraham, L.J., Piggott, M.J. 2014, 'Ethynylbenzenoid metabolites of Antrodia camphorata: Synthesis and inhibition of TNF expression', Organic and Biomolecular Chemistry, 12, 7, pp. 1100-1113. Detail Reynolds, C.J., Long, R.L., Flematti, G.R., Cherry, H., Turner, S.R. 2014, 'Karrikins promote germination of physiologically dormant seeds of Chrysanthemoides monilifera ssp. monilifera (boneseed)', Weed Research, 54, 1, pp. 48-57. Detail Bohman, B., Phillips, R.D., Menz, M.H.M., Berntsson, B.W., Flematti, G.R., Barrow, R.A., Dixon, K.W., Peakall, R. 2014, 'Discovery of pyrazines as pollinator sex pheromones and orchid semiochemicals: Implications for the evolution of sexual deception', New Phytologist, 203, 3, pp. 939-952. Detail Scaffidi, A., Waters, M.T., Sun, Y.K., Skelton, B.W., Dixon, K.W., Ghisalberti, E.L., Flematti, G.R., Smith, S.M. 2014, 'Strigolactone hormones and their stereoisomers signal through two related receptor proteins to induce different physiological responses in arabidopsis', Plant Physiology, 165, 3, pp. 1221-1232. Detail