Chooi, Yit Heng - University of Western Australia - School of Chemistry and Biochemistry

个人简介

ARC DECRA Fellow, Research School of Biology, Australian National University, 2013-15 Postdoc., Dept of Chemical & Biomolecular Engineering, University of California, Los Angeles (UCLA), 2009-13 PhD., School of Applied Science, RMIT University

研究领域

Discovering Untapped Natural Chemical Diversity with Genomics and Synthetic Biology Extended Central Dogma for Microbial Secondary Metabolite Biosynthesis Chemical ecogenomics approach for understanding the roles of secondary metabolites in plant pathogens

近期论文

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Discovery and heterologous biosynthesis of glycosylated polyketide luteodienoside A reveals unprecedented glucinol-mediated product offloading by a fungal carnitine O-acyltransferase domain Arishi, A. A., Shang, Z., Lacey, E., Crombie, A., Vuong, D., Li, H., Bracegirdle, J., Turner, P., Lewis, W., Flematti, G. R., Piggott, A. M. & Chooi, Y. H., 29 Jan 2024, In: Chemical Science. 15, 9, p. 3349-3356 8 p. Discovery of Two Novel Phthalide Phytotoxins from the Wheat Tan Spot Fungal Pathogen Pyrenophora tritici-repentis Rawlinson, C., Nealon, G., Chooi, Y. H., Oliver, R. P., Moffat, C. S. & See, P. T., 11 Sept 2024, In: Journal of Agricultural and Food Chemistry. 72, 36, p. 19594-19603 10 p. Ether-Diol Ambiguity: An Inconspicuous Issue in the Structure Elucidation of Oxygenated Natural Products Bulcock, B. W., Chen, R., Lacey, E., Chooi, Y. H. & Flematti, G. R., 23 Aug 2024, In: Journal of Natural Products. 87, 8, 9 p. Geministatins: new depside antibiotics from the fungus Austroacremonium gemini Crombie, A., Kalaitzis, J. A., Chen, R., Vuong, D., Lacey, A. E., Lacey, E., Shivas, R. G., Tan, Y. P., Sbaraini, N., Chooi, Y. H. & Piggott, A. M., Oct 2024, In: Journal of Antibiotics. 77, 10, p. 639-646 8 p. Heterologous Biosynthesis of the Sterol O-Acyltransferase Inhibitor Helvamide Unveils an α-Ketoglutarate-Dependent Cross-Linking Oxygenase Wang, R., Liang, J. J., Yang, W., Vuong, D., Kalaitzis, J. A., Lacey, A. E., Lacey, E., Piggott, A. M., Chooi, Y. H. & Li, H., 8 Mar 2024, In: Organic Letters. 26, 9, p. 1807-1812 6 p. Next-generation AMA1-based plasmids for enhanced heterologous expression in filamentous fungi Roux, I., Woodcraft, C., Sbaraini, N., Pepper, A., Wong, E., Bracegirdle, J. & Chooi, Y. H., Sept 2024, In: Microbial Biotechnology. 17, 9, e70010. The Velvet transcription factor PnVeA regulates necrotrophic effectors and secondary metabolism in the wheat pathogen Parastagonospora nodorum Morikawa, S., Verdonk, C., John, E., Lenzo, L., Sbaraini, N., Turo, C., Li, H., Jiang, D., Chooi, Y. H. & Tan, K. C., Dec 2024, In: BMC Microbiology. 24, 1, 299. CAGECAT: The CompArative GEne Cluster Analysis Toolbox for rapid search and visualisation of homologous gene clusters van den Belt, M., Gilchrist, C., Booth, T. J., Chooi, Y. H., Medema, M. H. & Alanjary, M., Dec 2023, In: BMC Bioinformatics. 24, 1, 181. Resorculins: hybrid polyketide macrolides from Streptomyces sp. MST-91080 Lacey, H. J., Chen, R., Vuong, D., Lacey, E., Rutledge, P. J., Chooi, Y. H., Piggott, A. M. & Booth, T. J., 28 Feb 2023, In: Organic and Biomolecular Chemistry. 21, 12, p. 2531-2538 8 p. Stereodivergent Hydroxylation of Berkeleylactones by Penicillium turbatum Cowled, M. S., Li, H., Gilchrist, C. L. M., Lacey, E., Chooi, Y-H. & Piggott, A. M., 24 Mar 2023, In: Journal of Natural Products. 86, 3, p. 541-549 9 p. Turonicin A, an Antifungal Linear Polyene Polyketide from an Australian Streptomyces sp. Chen, R., Minns, S. A., Kalaitzis, J. A., Butler, M. S., Rosin, M., Vuong, D., Lean, S. S., Chooi, Y. H., Lacey, E. & Piggott, A. M., 25 Aug 2023, In: Journal of Natural Products. 86, 8, p. 2054-2058 5 p. Cre/lox-Mediated Chromosomal Integration of Biosynthetic Gene Clusters for Heterologous Expression in Aspergillus nidulans Roux, I. & Chooi, Y-H., 18 Mar 2022, In: ACS Synthetic Biology. 11, 3, p. 1186-1195 10 p. Discovery, bioactivity and biosynthesis of fungal piperazines Wang, R., Piggott, A. M., Chooi, Y-H. & Li, H., 14 Nov 2022, In: Natural Product Reports. 40, 2, p. 387-411 25 p. Discovery of brevijanazines from Aspergillus brevijanus reveals the molecular basis for p-nitrobenzoic acid in fungi Li, H., Mirzayans, P. M., Butler, M. S., Lacey, A. E., Vuong, D., Chen, R., Kalaitzis, J. A., Moggach, S. A., Lacey, E., Piggott, A. M. & Chooi, Y. H., 4 May 2022, In: Chemical communications (Cambridge, England). 58, 43, p. 6296-6299 4 p. Effect of a reduced fat and sugar maternal dietary intervention during lactation on the infant gut microbiome Sindi, A. S., Stinson, L. F., Lean, S. S., Chooi, Y. H., Leghi, G. E., Netting, M. J., Wlodek, M. E., Muhlhausler, B. S., Geddes, D. T. & Payne, M. S., 17 Aug 2022, In: Frontiers in Microbiology. 13, 21 p., 900702. Heterologous Expression of Fungal Biosynthetic Pathways in Aspergillus nidulans Using Episomal Vectors Roux, I. & Chooi, Y. H., 2022, In: Methods in molecular biology (Clifton, N.J.). 2489, p. 75-92 18 p. Intra-hemocoel injection of pseurotin A from Metarhizium anisopliae, induces dose-dependent reversible paralysis in the Greater Wax Moth (Galleria mellonella) Sbaraini, N., Phan, C. S., Silva e Souza, E., Perin, A. P. A., Rezaee, H., Geremia, F., da Silva Camargo, M., Barbosa, E. G., Schrank, A., Chooi, Y. H. & Staats, C. C., Apr 2022, In: Fungal Genetics and Biology. 159, 103675. Out for a RiPP: challenges and advances in genome mining of ribosomal peptides from fungi Kessler, S. C. & Chooi, Y-H., Feb 2022, In: Natural Product Reports. 39, 2, p. 222-230 9 p. RiPP-ing through the plant kingdom Chooi, Y. H., Jan 2022, In: Nature Chemical Biology. 18, 1, p. 2-3 2 p. The expanding CRISPR toolbox for natural product discovery and engineering in filamentous fungi Woodcraft, C., Chooi, Y-H. & Roux, I., 7 Oct 2022, In: Natural Product Reports. 40, 1, p. 158-173 16 p. cblaster: a remote search tool for rapid identification and visualization of homologous gene clusters Gilchrist, C., Booth, T., van Wersch, B., van Grieken, L., Medema, M. H. & Chooi, Y-H., 5 Aug 2021, In: Bioinformatics Advances. 1, 1, vbab016. Characterisation and heterologous biosynthesis of burnettiene A, a new polyene-decalin polyketide from Aspergillus burnettii Roux, I., Bowles, S., Kalaitzis, J. A., Vuong, D., Lacey, E., Chooi, Y-H. & Piggott, A. M., 21 Nov 2021, In: Organic & Biomolecular Chemistry. 19, 43, p. 9506-9513 8 p. Chlorinated metabolites from Streptomyces sp. highlight the role of biosynthetic mosaics and superclusters in the evolution of chemical diversity Morshed, M. T., Lacey, E., Vuong, D., Lacey, A. E., Lean, S. S., Moggach, S. A., Karuso, P., Chooi, Y. H., Booth, T. J. & Piggott, A. M., 21 Jul 2021, In: Organic and Biomolecular Chemistry. 19, 27, p. 6147-6159 13 p. clinker & clustermap.js: automatic generation of gene cluster comparison figures Gilchrist, C. L. M. & Chooi, Y., 15 Aug 2021, In: Bioinformatics. 37, 16, p. 2473-2475 3 p. Genome Mining of Aspergillus hancockii Unearths Cryptic Polyketide Hancockinone A Featuring a Prenylated 6/6/6/5 Carbocyclic Skeleton Li, H., Shu, S., Kalaitzis, J. A., Shang, Z., Vuong, D., Crombie, A., Lacey, E., Piggott, A. M. & Chooi, Y-H., 19 Nov 2021, In: Organic Letters. 23, 22, p. 8789–8793 5 p. Hancockiamides: phenylpropanoid piperazines fromAspergillus hancockiiare biosynthesised by a versatile dual single-module NRPS pathway Li, H., Lacey, A. E., Shu, S., Kalaitzis, J. A., Vuong, D., Crombie, A., Hu, J., Gilchrist, C. L. M., Lacey, E., Piggott, A. M. & Chooi, Y. H., 21 Jan 2021, In: Organic and Biomolecular Chemistry. 19, 3, p. 587-595 9 p. Polyketides produced by the entomopathogenic fungus Metarhizium anisopliae induce Candida albicans growth Sbaraini, N., Hu, J., Roux, I., Phan, C. S., Motta, H., Rezaee, H., Schrank, A., Chooi, Y. H. & Staats, C. C., Jul 2021, In: Fungal Genetics and Biology. 152, 103568. Synthaser: a CD-Search enabled Python toolkit for analysing domain architecture of fungal secondary metabolite megasynth(et)ases Gilchrist, C. & Chooi, Y-H., Dec 2021, In: Fungal Biology and Biotechnology. 8, 1, 13. The genome of Micrococcus luteus MST-118984C isolated from Australian soil harbours a bacteriocin biosynthetic gene cluster and biocide/multidrug efflux genes Lean, S. S., Shang, A. Z., Booth, T., Lacey, E. & Chooi, Y. H., Sept 2021, In: International Journal of Antimicrobial Agents. 58, 21002727. Biosynthesis of a New Benzazepine Alkaloid Nanangelenin A from Aspergillus nanangensis Involves an Unusual l-Kynurenine-Incorporating NRPS Catalyzing Regioselective Lactamization Li, H., Gilchrist, C. L. M., Phan, C-S., Lacey, H. J., Vuong, D., Moggach, S. A., Lacey, E., Piggott, A. M. & Chooi, Y-H., 15 Apr 2020, In: Journal of the American Chemical Society. 142, 15, p. 7145-7152 8 p. Comprehensive chemotaxonomic and genomic profiling of a biosynthetically talented Australian fungus, Aspergillus burnettii sp. nov. Gilchrist, C. L. M., Lacey, H. J., Vuong, D., Pitt, J. I., Lange, L., Lacey, E., Pilgaard, B., Chooi, Y. H. & Piggott, A. M., Oct 2020, In: Fungal Genetics and Biology. 143, 103435. Conglobatins B-E: cytotoxic analogues of the C2-symmetric macrodiolide conglobatin Lacey, H. J., Booth, T. J., Vuong, D., Rutledge, P. J., Lacey, E., Chooi, Y-H. & Piggott, A. M., 1 Nov 2020, In: Journal of Antibiotics. 73, 11, p. 756–765 10 p. CRISPR-Mediated Activation of Biosynthetic Gene Clusters for Bioactive Molecule Discovery in Filamentous Fungi Roux, I., Woodcraft, C., Hu, J., Gilchrist, C. L. M. & Chooi, Y-H., 17 Jul 2020, In: ACS Synthetic Biology. 9, 7, p. 1843-1854 12 p. Fungal Dirigent Protein Controls the Stereoselectivity of Multicopper Oxidase-Catalyzed Phenol Coupling in Viriditoxin Biosynthesis Hu, J., Li, H. & Chooi, Y-H., 2020, In: Journal of the American Chemical Society. 141, 20, p. 8068-8072 5 p. Fungal planet description sheets: 1042-1111 Crous, P. W., Wingfield, M. J., Chooi, Y. H., Gilchrist, C. L. M., Lacey, E., Pitt, J. I., Roets, F., Swart, W. J., Cano-Lira, J. F., Valenzuela-Lopez, N., Hubka, V., Shivas, R. G., Stchigel, A. M., Holdom, D. G., Jurjević, Ž., Kachalkin, A. V., Lebel, T., Lock, C., Martín, M. P., Tan, Y. P., & 139 others, Jul 2020, In: Persoonia: Molecular Phylogeny and Evolution of Fungi. 44, p. 301-459 159 p. Fungal Polyketide-Nonribosomal Peptide Synthetases and Their Associated Natural Products Li, H., Booth, T. & Chooi, Y-H., 2020, Comprehensive Natural Products III: Chemistry and Biology. Liu, H-W. & Begley, T. P. (eds.). 3 ed. Elsevier, Vol. 1. p. 415-444 Genomics-Driven Discovery of Phytotoxic Cytochalasans Involved in the Virulence of the Wheat Pathogen Parastagonospora nodorum Li, H., Wei, H., Hu, J., Lacey, E., Sobolev, A. N., Stubbs, K. A., Solomon, P. S. & Chooi, Y. H., 17 Jan 2020, In: ACS Chemical Biology. 15, 1, p. 226-233 8 p. Three Recently Diverging Duplicated Methyltransferases Exhibit Substrate-Dependent Regioselectivity Essential for Xantholipin Biosynthesis Kong, L., Wang, Q., Yang, W., Shen, J., Li, Y., Zheng, X., Wang, L., Chu, Y., Deng, Z., Chooi, Y. H. & You, D., 21 Aug 2020, In: ACS Chemical Biology. 15, 8, p. 2107-2115 9 p. Victorin, the host-selective cyclic peptide toxin from the oat pathogen Cochliobolus victoriae, is ribosomally encoded Kessler, S. C., Zhang, X., McDonald, M. C., Gilchrist, C. L. M., Lin, Z., Rightmyer, A., Solomon, P. S., Gillian Turgeon, B. & Chooi, Y. H., 29 Sept 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 39, p. 24243-24250 8 p. Volatile Molecules Secreted by the Wheat Pathogen Parastagonospora nodorum Are Involved in Development and Phytotoxicity Muria-Gonzalez, M. J., Yeng, Y., Breen, S., Mead, O., Wang, C., Chooi, Y. H., Barrow, R. A. & Solomon, P. S., 25 Mar 2020, In: Frontiers in Microbiology. 11, 466. Acquisition and Loss of Secondary Metabolites Shaped the Evolutionary Path of Three Emerging Phytopathogens of Wheat Thynne, E., Mead, O. L., Chooi, Y. H., McDonald, M. C. & Solomon, P. S., 1 Mar 2019, In: Genome Biology and Evolution. 11, 3, p. 890-905 16 p. Biosynthesis of a Tricyclo[6.2.2.02,7]dodecane System by a Berberine Bridge Enzyme-Like Aldolase Li, H., Hu, J., Wei, H., Solomon, P. S., Stubbs, K. A. & Chooi, Y. H., 27 Nov 2019, In: Chemistry - A European Journal. 25, 66, p. 15062-15066 5 p. Biosynthesis of bioactive natural products from Basidiomycota Lin, H-C., Hewage, R. T., Lu, Y-C. & Chooi, Y-H., 7 Feb 2019, In: Organic & Biomolecular Chemistry. 17, 5, p. 1027-1036 10 p. Bipolenins K-N: New sesquiterpenoids from the fungal plant pathogen Bipolaris sorokiniana Phan, C. S., Li, H., Kessler, S., Solomon, P. S., Piggott, A. M. & Chooi, Y. H., 9 Aug 2019, In: Beilstein Journal of Organic Chemistry. 15, p. 2020-2028 9 p. Discovery and Heterologous Biosynthesis of the Burnettramic Acids: Rare PKS-NRPS-Derived Bolaamphiphilic Pyrrolizidinediones from an Australian Fungus, Aspergillus burnettii Li, H., Gilchrist, C. L. M., Lacey, H. J., Crombie, A., Vuong, D., Pitt, J. I., Lacey, E., Chooi, Y. H. & Piggott, A. M., 1 Mar 2019, In: Organic Letters. 21, 5, p. 1287-1291 5 p. Heterologous biosynthesis of elsinochrome A sheds light on the formation of the photosensitive perylenequinone system Hu, J., Sarrami, F., Li, H., Zhang, G., Stubbs, K. A., Lacey, E., Stewart, S. G., Karton, A., Piggott, A. M. & Chooi, Y-H., 7 Feb 2019, In: Chemical Science. 10, 5, p. 1457-1465 9 p. Nanangenines: Drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensis Lacey, H. J., Gilchrist, C. L. M., Crombie, A., Kalaitzis, J. A., Vuong, D., Rutledge, P. J., Turner, P., Pitt, J. I., Lacey, E., Chooi, Y. H. & Piggott, A. M., 5 Nov 2019, In: Beilstein Journal of Organic Chemistry. 15, p. 2631-2643 13 p. The fungal gene cluster for biosynthesis of the antibacterial agent viriditoxin Urquhart, A. S., Hu, J., Chooi, Y-H. & Idnurm, A., 1 Jul 2019, In: Fungal Biology and Biotechnology. 6, 1, p. 2 9. The identification and deletion of the polyketide synthase-nonribosomal peptide synthase gene responsible for the production of the phytotoxic triticone A/B in the wheat fungal pathogen Pyrenophora tritici-repentis Rawlinson, C., See, P. T., Moolhuijzen, P., Li, H., Moffat, C. S., Chooi, Y. H. & Oliver, R. P., 1 Dec 2019, In: Environmental Microbiology. 21, 12, p. 4875-4886 12 p.