Arthur, Peter - University of Western Australia - School of Chemistry and Biochemistry

研究领域

PGA is an active multidisciplinary researcher with expertise in oxidative stress, a process when reactive oxygen species (ROS), also known as free radicals, overwhelm the body’s antioxidant defences. ROS are thought to contribute to the complications of many chronic and lifestyle diseases such as muscle wasting, blindness, Alzheimer’s, emphysema, muscular dystrophy, Parkinson’s disease, diabetes, renal failure and aging. To progress research on ROS, PGA is involved in collaborative research with others involved in a range of disciplines including neurotrauma, exercise science, physiology, anatomy, zoologists, and agriculture. As a consequence of multidisciplinary research, PGA has been involved in projects utilising cell culture, animal models and human subjects. To support this research, PGA has led the development of novel techniques sensitive enough to identify proteins undergoing reversible thiol oxidation (see patents). This work led to the discovery that protein thiol oxidation was elevated in dystrophic muscle tissue and we have linked prevention of protein thiol oxidation to decreased muscle damage.

近期论文

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Terrill, J.R., Pinniger, G.J., Graves, J.A., Grounds, M.D., Arthur, P.G. 2016, 'Increasing taurine intake and taurine synthesis improves skeletal muscle function in the mdx mouse model for Duchenne muscular dystrophy', The Journal of Physiology, JP271418 - vol 594, pp. 1-16. Detail Arthur, P., Ludwig, M., Castelli, J., Kirkwood, P., Attwood, P. 2016, 'Prepare, Do, Review: A skills-based approach for laboratory practical classes in biochemistry and molecular biology', Biochemistry and Molecular Biology Education, 44, 3, pp. 276-287. Detail Terrill, J.R., Duong, M.N., Turner, R., Le Guiner, C., Boyatzis, A., Kettle, A.J., Grounds, M.D., Arthur, P.G. 2016, 'Levels of inflammation and oxidative stress, and a role for taurine in dystropathology of the Golden Retriever Muscular Dystrophy dog model for Duchenne Muscular Dystrophy', Redox Biology, 9, pp. 276-286. Detail Lim, C., Prêle, C.M., Baltic, S., Arthur, P.G., Creaney, J., Neil Watkins, D., Thompson, P.J., Mutsaers, S.E. 2015, 'Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis', Oncotarget, 6, 3, pp. 1519-1530. Detail Tan, P.L., Shavlakadze, T., Grounds, M.D., Arthur, P.G. 2015, 'Differential thiol oxidation of the signaling proteins Akt, PTEN or PP2A determines whether Akt phosphorylation is enhanced or inhibited by oxidative stress in C2C12 myotubes derived from skeletal muscle', International Journal of Biochemistry and Cell Biology, 62, pp. 72-79. Detail Terrill, J.R., Grounds, M.D., Arthur, P.G. 2015, 'Taurine deficiency, synthesis and transport in the mdx mouse model for Duchenne Muscular Dystrophy', International Journal of Biochemistry and Cell Biology, 66, pp. 141-148. Detail Mashimo, K., Arthur, P.G., Ohno, Y. 2015, 'Ethanol dose-and time-dependently increases a and ß subunits of mitochondrial ATP synthase of cultured neonatal rat cardiomyocytes', Journal of Nippon Medical School, 82, 5, pp. 237-245. Detail Tohma, H., El-Shafey, A.F., Croft, K.D., Shavlakadze, T., Grounds, M.D., Arthur, P.G. 2014, 'Protein thiol oxidation does not change in skeletal muscles of aging female mice', Biogerontology, 15, 1, pp. 87-98. Detail Molinari, C.E., Casadio, Y.S., Hartmann, B.T., Arthur, P.G., Hartmann, P.E. 2013, 'Longitudinal analysis of protein glycosylation and β-casein phosphorylation in term and preterm human milk during the first 2 months of lactation', BRITISH JOURNAL OF NUTRITION, 110, 1, pp. 105-115. Detail Arthur, P.G., Niu, X.-W., Huang, W.-H., DeBoer, B., Lai, C.T., Rossi, E., Joseph, J., Jeffrey, G.P. 2013, 'Desferrioxamine in warm reperfusion media decreases liver injury aggravated by cold storage', World Journal of Gastroenterology, 19, 5, pp. 673-681. Detail Terrill, J.R., Radley-Crabb, H.G., Iwasaki, T., Lemckert, F.A., Arthur, P.G., Grounds, M.D. 2013, 'Oxidative stress and pathology in muscular dystrophies: focus on protein thiol oxidation and dysferlinopathies', The FEBS Journal, 280, 17, pp. 4149-4164. Detail Terrill, J.R., Boyatzis, A., Grounds, M.D., Arthur, P.G. 2013, 'Treatment with the cysteine precursor L-2-oxothiazolidine-4-carboxylate (OTC) implicates taurine deficiency in severity of dystropathology in mdx mice', The International Journal of Biochemistry & Cell Biology, 45, 9, pp. 2097-2108. Detail Iwasaki, T., Terrill, J., Shavlakadze, T., Grounds, M.D., Arthur, P.G. 2013, 'Visualizing and quantifying oxidized protein thiols in tissue sections: A comparison of dystrophic mdx and normal skeletal mouse muscles', Free Radical Biology and Medicine, 65, pp. 1408-1416. Detail Molinari, C.E., Casadio, Y.S., Hartmann, B.T., Livk, A., Bringans, S., Arthur, P.G., Hartmann, P.E. 2012, 'Proteome Mapping of Human Skim Milk Proteins in Term and Preterm Milk', Journal of Proteome Research, 11, pp. 1696-1714. Detail Terrill, J., Radley, H.G., Grounds, M.D., Arthur, P.G. 2012, 'N-Acetylcysteine treatment of dystrophic mdx mice results in protein thiol modifications and inhibition of exercise induced myofibre necrosis', NEUROMUSCULAR DISORDERS, 22, pp. 427-434. Detail Radley-Crabb, H.G., Terrill, J., Shavlakadze, T., Tonkin, J.N., Arthur, P.G., Grounds, M.D. 2012, 'A single 30 min treadmill exercise session is suitable for 'proof-of concept studies' in adult mdx mice: A comparison of the early consequences of two different treadmill protocols', NEUROMUSCULAR DISORDERS, 22, pp. 170-182. Detail El-Shafey, A, Armstrong, A.E., Terrill, J., Grounds, M.D., Arthur, P.G. 2011, 'Screening for increased protein thiol oxidation in oxidatively stressed muscle tissue', FREE RADICAL RESEARCH, 17 May 2011, pp. 1-9. Detail Tohma, H., Hepworth, A.R., Shavlakadze, T., Grounds, M.D., Arthur, P.G. 2011, 'Quantification of Ceroid and Lipofuscin in Skeletal Muscle', JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 59, 8, pp. 769-779. Detail Molinari, C.E., Casadio, Y.S., Arthur, P.G., Hartmann, P.E. 2011, 'The effect of storage at 25 degrees C on proteins in human milk', INTERNATIONAL DAIRY JOURNAL, 21, pp. 286-293. Detail Armstrong, A.E., Zerbes, R., Fournier, P.A., Arthur, P.G. 2011, 'A fluorescent dual labeling technique for the quantitative measurement of reduced and oxidized protein thiols in tissue samples', FREE RADICAL BIOLOGY AND MEDICINE, 50, pp. 510-517. Detail