个人简介

A.B. 1980, Barnard College Ph.D. 1986, University of California at Berkeley Fulford Junior Research Fellow, Oxford University 1986-88 Henry Rutgers Research Fellow Awards & Honors Editorial Board for Letters in Peptide Science Alfred P. Sloan Fellow Rutgers University Board of Trustees Scholarly Excellence Fellowship Margaret O. Dayhoff Biophysical Society Award Camille & Henry Dreyfus Teacher-Scholar Award Johnson and Johnson Discovery Research Fund Searle Scholar

研究领域

Analytical Chemistry

The Baum Group studies protein-protein interaction and protein aggregation through biochemical and biophysical techniques, including Nuclear Magnetic Resonance

近期论文

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Moriarty, G.M., C. Minetti, D.P. Remeta, and J. Baum. "A Revised Picture of the Cu(II) α-Synuclein Complex: The Role of N-Terminal Acetylation", in press, Biochemistry (2014). Moriarty, G.M., M.K. Janowska, L. Kang, and J. Baum. "Exploring the accessible conformations of N-terminal acetylated α-synuclein", FEBS Lett., 587(8), 1128-38 (2013). Kang, L., M.K. Janowska, G.M. Moriarty, and J. Baum. "Mechanistic insight into the relationship between N-terminal acetylation of α-synuclein and fibril formation rates by NMR and fluorescence", PLoS One, 8(9), e75018 (2013). Kim, S., K-P Wu, and J. Baum. "Fast hydrogen exchange affects ¹⁵N relaxation measurements in intrinsically disordered proteins", J. Biomol NMR, 55(3), 249-56 (2013). Narayanan, C., D.S. Weinstock, K-P Wu, J. Baum, and RM Levy. "Investigation of the Polymeric Properties of α-Synuclein and Comparison with NMR Experiments: A Replica Exchange Molecular Dynamics Study", J. Chem Theory Comput., 3939-3942 (2012). Kang, L., G.M. Moriarty, L.A. Woods, A.E. Ashcroft, S.E. Radford, and J. Baum. "N-terminal acetylation of α-synuclein induces increased transient helical propensity and decreased aggregation rates in the intrinsically disordered monomer" Protein Sci., 7, 911-7 (2012). Xiao, J., B. Madhan, Y. Li, B. Brodsky, and J. Baum. "Osteogenesis imperfecta model peptides: incorporation of residues replacing Gly within a triple helix achieved by renucleation and local flexibility", J. Biophysical, 101(2), 449-58 (2011). Xiao, J., H. Cheng, T. Silva, J. Baum, and B. Brodsky. "Osteogenesis imperfecta missense mutations in collagen: structural consequences of a glycine to alanine replacement at a highly charged site", Biochemistry, 50, 10771-80 (2011). Kang, L., K-P Wu, M. Vendruscolo, and J. Baum. "The A53T mutation is key in defining the differences in the aggregation kinetics of human and mouse α-synuclein", J Am Chem Soc., 133(34):13465-70 (2011). Wu, K-P, and J. Baum. "Backbone assignment and dynamics of human α-synuclein in viscous 2 M glucose solution", Biomol NMR Assign., 5(1), 43-6 (2011). Xiao, J., RM Addabbo, JL Lauer, GB Fields, and J. Baum. "Local conformation and dynamics of isoleucine in the collagenase cleavage site provide a recognition signal for matrix metalloproteinases", J Biol Chem., 285(44), 34181-90 (2010). Wu, K-P and J. Baum "Detection of transient inter-chain interactions in the intrinsically disordered protein alpha-synuclein by NMR paramagnetic relaxation enhancement" J. Am. Chem. Soc. Communication, 133(34) 13465-70 (2010). Xiao, J. and J. Baum "Structural insights from 15N relaxation data for an anisotropic collagen peptide" J. Am. Chem. Soc. Communication, 131(51), 18194-5 (2009). Wu K-P., D.S. Weinstock, C. Narayanan, R.M. Levy, and J. Baum. "Structural reorganization of α-synuclein at low pH observed by NMR and REMD simulations", J. Mol. Biol., 391(4):784-96. (2009). Li, Y.J., B. Brodsky and J. Baum. "NMR conformational and dynamic consequences of a Gly to Ser substitution in an osteogenesis imperfecta collagen model peptide" J. Biol. Chem., 284(31), 20660-20667 (2009). Chen, Y-J., K-P. Wu, S. Kim, L. Falzon, M. Inouye and J. Baum. "Backbone NMR assignments of DFP-inhibited mature subtilisin E" Biomolecular NMR Assignments, 2:131–133 (2008). Thiagarajan, G., Y. Li, A. Mohs, C. Strafaci, M. Popiel, J. Baum, and B. Brodsky. "Common interruptions in the repeating tripeptide sequence of non-fibrillar collagens: Sequence analysis and structural studies on triple-helix peptide models", J. Mol. Biol., 376(3), 736-48 (2008). Weinstock, D.S., C. Narayanan, J. Baum, and R.M. Levy. "Correlation between 13C-alpha chemical shifts and helix content of peptide ensembles", Protein Science, 17(5), 950-4 (2008). Wu, K-P, S. Kim, D.A. Fela and J. Baum. "Characterization of conformational and dynamic properties of natively unfolded human and mouse alpha;-synuclein ensembles by NMR: implication for aggregation", J. Mol. Biol., 378(5), 1104-15 (2008). Brodsky, B. and J. Baum. "Structural biology: Modeling collagen diseases" Nature, 453(7198), 998-9 (2008). Madhan, B., J. Xiao, G. Thiagarajan, J. Baum and B. Brodsky. "NMR monitoring of chain-specific stability in heterotrimeric collagen peptides" J. Am. Chem. Soc., 130(41), 13520-1 (2008). Go, A., S. Kim, J. Baum and M.H. Hecht. "Structure and dynamics of de novo proteins from a designed superfamily of 4-helix bundles" Protein Science, 17(5), 821-32 (2008). Weinstock, D.S., C. Naranayan, A.K. Felts, M, Andrec, R.M. Levy, K-P. Wu, and J. Baum. "Distingusihing among structural ensembles of the GB1 peptide: REMD simulations and NMR experiments", J. Am. Chem. Soc., 129(16), 4858-9. (2007). Baum, J. Protein Folding Protocols. Methods in Molecular Biology, 350 Edited by Yawen Bai (National Institutes of Health, Bethesda, MD) and Ruth Nussinov (National Cancer Institute, Frederick, MD and Tel Aviv University, Israel). Humana Press: Totowa, NJ. 2006 review in J. Am. Chem. Soc., 129(38), 11873 (2007). Li, Y., B. Brodsky, and J. Baum. "NMR shows hydrophobic interactions replace glycine packing in the triple helix at a natural break in the (Gly-X-Y)n repeat", J. Biol. Chem., 282(31), 22699-706 (2007). Go, A., S. Kim, M. Hecht, and J. Baum. "NMR assignment of S836: a de novo protein from a designed superfamily", Biomolecular NMR assignments, 1(2), 213-215 (2007). Mohs, A., M. Popiel, Y. Li, J. Baum, and B. Brodsky. "Conformational features of a natural break in the type IV collagen Gly-X-Y repeat", J. Biol. Chem., 281(25), 17197-202 (2006). Hyde, T., M. Bryan, B. Brodsky, and J. Baum. "Sequence dependence of renucleation after a Gly mutation in model collagen peptides", J. Biol. Chem., 281(48), 36937-43 (2006). Mohs, A., Y. Li, E. Doss-Pepe, J. Baum and B. Brodsky. "Stability junction at a common mutation site in the collagenous domain of the mannose binding lectin", Biochemistry, 44, 1793-9 (2005). Li, Y., S. Kim, B. Brodsky, and J. Baum. "Identification of partially disordered peptide intermediates through residue specific NMR diffusion measurements", J. Am. Chem. Soc., 127, 10490-1 (2005).