Bond, Charles - University of Western Australia - School of Chemistry and Biochemistry

研究领域

As a structural biologist, Prof. Bond studies the three dimensional structure of biological molecules, such as nucleic acids and proteins, which helps to explain how the molecules function. The applications of Prof. Bond’s studies are very broad and far reaching. Protein structures can be used as a basis to design drugs to treat infectious diseases, and researching how proteins contribute to errors in DNA and RNA expression increases our understanding of how cancers and other disorders are caused, and how they might be treated.

近期论文

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Cheng, S., Gutmann, B.C., Zhong, X., Ye, Y., Fisher, M.F., Bai, F., Castleden, I.R., Song, Y., Song, B., Huang, J., Liu, X., Xu, X., Lim, B.L, Bond, C.S., Yiu, S.M., Small, I. 2016, 'Redefining the structural motifs that determine RNA binding and RNA editing by pentatricopeptide repeat proteins in land plants', The Plant Journal, 85, 4, pp. 532-547. Detail Knott, G.J., Panjikar, S., Thorn, A., Fox, A.H., Conte, M.R., Lee, M., Bond, C.S. 2016, 'A crystallographic study of human NONO (p54^nrb): overcoming pathological problems with purification, data collection and noncrystallographic symmetry', Acta Crystallographica Section D-Structural Biology, D72, pp. 761-769. Detail Newsholme, P., Hartmann, P., Tuckey, R., Bond, C. 2015, 'Biochemistry in Western Australia', Biochemist, 37, 6, pp. 32-34. Detail Hennig, S., Kong, G.S., Mannen, T., Sadowska, A., Kobelke, S.J., Blythe, A.J., Knott, G.J., Swaminatha Iyer, K.L., Ho, D., Newcombe, E.A., Hosoki, K., Goshima, N., Kawaguchi, T., Hatters, D., Trinkle-Mulcahy, L., Hirose, T., Bond, C.S., Fox, A. 2015, 'Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles', JOURNAL OF CELL BIOLOGY, 210, pp. 529-539. Detail Knott, G.J., Lee, M, Passon, D.M., Fox, A., Bond, C.S. 2015, 'Caenorhabditis elegans NONO-1: Insights into DBHS protein structure, architecture, and function', PROTEIN SCIENCE, 24, pp. 2033-2043. Detail Gully, B.S., Shah, K.R., Lee, M., Shearston, K.D., Smith, N.M., Sadowska, A., Blythe, A.J., Bernath-Levin, K., Stanley, W.A., Small, I., Bond, C.S. 2015, 'The design and structural characterization of a synthetic pentatricopeptide repeat protein', ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 71, 2, pp. 196-208. Detail Shi, M.W., Sobolev, A.N., Schirmeister, T., Engels, B., Schmidt, T.C., Luger, P., Mebs, S., Dittrich, B., Chen, Y., Bak, J.M., Jayatilaka, D., Bond, C.S., Turner, M.J., Stewart, S.G., Spackman, M.A., Grabowsky, S. 2015, 'Electrostatic complementarity in pseudoreceptor modeling based on drug molecule crystal structures: The case of loxistatin acid (E64c)', New Journal of Chemistry, 39, pp. 1628-1633. Detail Kindgren, P., Yap, A., Bond, C.S., Small, I.D. 2015, 'Predictable alteration of sequence recognition by RNA editing factors from arabidopsis', Plant Cell, 27, 2, pp. 403-416. Detail Lee, M., Sadowska, A., Bekere, I., Ho, D., Gully, B.S., Lu, Y., Swaminatha Iyer, K.L., Trewhella, J., Fox, A.H., Bond, C.S. 2015, 'The structure of human SFPQ reveals a coiled-coil mediated polymer essential for functional aggregation in gene regulation', Nucleic Acids Research, 43, 7, pp. 3826-3840. Detail Gully, B.S., Cowieson, N., Stanley, W.A., Shearston, K., Small, I.D., Barkan, A., Bond, C.S. 2015, 'The solution structure of the pentatricopeptide repeat protein PPR10 upon binding atpH RNA', Nucleic Acids Research, 43, 3, pp. 1918-1926. Detail Conn, C.E., Bythell-Douglas, R., Neumann, D., Yoshida, S., Whittington, B., Westwood, J.H., Shirasu, K., Bond, C.S., Dyer, K.A., Nelson, D.C. 2015, 'Convergent evolution of strigolactone perception enabled host detection in parasitic plants', Science, 349, 6247, pp. 540-543. Detail Bythell-Douglas, R., Suttisansanee, U., Flematti, G.R., Challenor, M., Lee, M., Panjikar, S.K., Honek, J.F., Bond, C.S. 2015, 'The crystal structure of a homodimeric Pseudomonas glyoxalase I enzyme reveals asymmetric metallation commensurate with half-of-sites activity', CHEMISTRY-A EUROPEAN JOURNAL, 21, 2, pp. 541-544. Detail Boussardon, C., Avon, A., Kindgren, P., Bond, C.S., Challenor, M., Lurin, C., Small, I.D. 2014, 'The cytidine deaminase signature HxE(x)nCxxC of DYW1 binds zinc and is necessary for RNA editing of ndhD-1', New Phytologist, 203, 4, pp. 1090-1095. Detail Meyer, G.R., Aragão, D., Mudie, N.J., Caradoc-Davies, T.T., Mcgowan, S., Bertling, P.J., Groenewegen, D., Quenette, S.M., Bond, C.S., Buckle, A.M., Androulakis, S.G. 2014, 'Operation of the Australian Store. Synchrotron for macromolecular crystallography', ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY, 70, 10, pp. 2510-2519. Detail Middleton, C.L., Parker, J.L., Knott, G.J., White, M.F., Bond, C.S. 2014, 'Crystal 'unengineering': Reducing the crystallisability of sulfolobus solfataricus hjc', Australian Journal of Chemistry, 67, 12, pp. 1818-1823. Detail Pröpper, K., Holstein, J.J., Hübschle, C.B., Bond, C.S., Dittrich, B. 2013, 'Invariom refinement of a new monoclinic solvate of thiostrepton at 0.64 Å resolution', Acta Crystallographica Section D: Biological Crystallography, 69, pp. 1530-1539. Detail Bythell-Douglas, R., Waters, M.T., Scaffidi, A., Flematti, G.R., Smith, S.M., Bond, C.S. 2013, 'The Structure of the Karrikin-Insensitive Protein (KAI2) in Arabidopsis thaliana', PLoS ONE, 8, 1, pp. 1-8. Detail Ling, I., Swaminatha Iyer, K.L., Bond, C.S., Sobolev, A.N., Alias, Y., Raston, C.L. 2012, 'Sodium ion association via bridging water molecules for different charged p-phosphonated calix[4]arene bilayers', CrystEngComm, 14, pp. 8541–8546. Detail Scaffidi, A., Waters, M.T., Bond, C.S., Dixon, K.W., Smith, S.M., Ghisalberti, E.L., Flematti, G.R. 2012, 'Exploring the molecular mechanism of karrikins and strigolactones', BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 22, 11, pp. 3743-3746. Detail Scaffidi, A., Waters, M.T., Skelton, B.W., Bond, C.S., Sobolev, A.N., Bythell-Douglas, R., McKinley, A.J., Dixon, K.W., Ghisalberti, E.L., Smith, S.M., Flematti, G.R. 2012, 'Solar irradiation of the seed germination stimulant karrikinolide produces two novel head-to-head cage dimers', ORGANIC & BIOMOLECULAR CHEMISTRY, 10, pp. 4069-4073. Detail