Terpolilli, Jason - Murdoch University - School of Veterinary and Life Sciences，Molecular and Biomedical Sciences

研究领域

My specific areas of research are: Understanding what determines how effective nitrogen-fixing symbiotic interactions are with the aim of identifying the genetic basis of highly effective symbioses. Applying this information to agriculture will result in more nitrogen fed into the system, a decreased reliance on synthetic fertilisers and ultimately an increase in the N-economy and sustainability of the system. Unravelling the basis of ‘selective nodulation’: One of the biggest problems facing the introduction of new legume species into existing farming systems is the aggressive nodulation of these hosts by ‘resident’ soil rhizobia which fix little or no N. Often, this occurs even when an elite inoculant strain capable of highly effective fixation is supplied with the legume. However a phenomenon of selective nodulation has been identified at the Centre for Rhizobium studies, whereby a host legume can select for a strain capable of highly efficient nitrogen fixation, even if the effective strain is outnumbered in the soil by poorly effective isolates. This work aims to identify the determinants of this phenomenon and apply the findings in the field. Studying root nodule bacteria metabolism and physiology to explain how these organisms cope and survive in the diverse environments of the soil, nodule and plant infection threads as well as understanding how nitrogen fixation is regulated by the plant.

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Haskett, T., Wang, P., Ramsay, J., O'Hara, G., Reeve, W., Howieson, J., Terpolilli, J., (2016), Complete Genome Sequence of Mesorhizobium ciceri bv. biserrulae Strain WSM1284, an Efficient Nitrogen-Fixing Microsymbiont of the Pasture Legume Biserrula pelecinus, Genome Announcements, 4, 3, pages -. Haskett, T., Wang, P., Ramsay, J., O'Hara, G., Reeve, W., Howieson, J., Terpolilli, J., (2016), Complete Genome Sequence of Mesorhizobium ciceri Strain CC1192, an Efficient Nitrogen-Fixing Microsymbiont of Cicer arietinum, Genome Announcements, 4, 3, pages -. Terpolilli, J., Tian, T., Yates, R., Howieson, J., Reeve, W., Poole, P., Munk, C., Tapia, R., Han, C., Markowitz, V., Tatiparthi, R., Mavrommatis, K., Ivanova, N., Pati, A., Goodwin, L., Woyke, T., Kyrpides, N., (2014), Genome sequence of Rhizobium leguminosarum bv trifolii strain WSM1689, the microsymbiont of the one flowered clover Trifolium uniflorum, Standards in Genomic Sciences, 9, , pages 527 - 539. Reeve, W., Ardley, J., Tian, T., De Meyer, S., Terpolilli, J., Melino, V., Tiwari, R., Yates, R., O'Hara, G., Howieson, J., Ninawi, M., Zhang, X., Bruce, D., Detter, C., Tapia, R., Han, C., Wei, C., Huntemann, M., Han, J., Chen, I., Mavromatis, K., Markowitz, V., Szeto, E., Ivanova, N., Pagani, I., Pati, A., Goodwin, L., Woyke, T., Kyrpides, N., (2014), Genome sequence of the Listia angolensis microsymbiont Microvirga lotononidis strain WSM3557T, Standards in Genomic Sciences, 9, , pages 540 - 550. Garau, G., Terpolilli, J., Hill, Y., Tian, T., Howieson, J., Brau, L., Goodwin, L., Han, C., Reddy, T., Huntemann, M., Pati, A., Woyke, T., Mavrommatis, K., Markowitz, V., Ivanova, N., Kyrpides, N., Reeve, W., (2014), Genome sequence of Ensifer medicae Di28; an effective N2-fixing microsymbiont of Medicago murex and M. polymorpha, Standards in Genomic Sciences, 9, 4, pages -. Reeve, W., Terpolilli, J., Melino, V., Ardley, J., Tian, T., De Meyer, S., Tiwari, R., Yates, R., O'Hara, G., Howieson, J., Ninawi, M., Held, B., Bruce, D., Detter, C., Tapia, R., Han, C., Wei, C., Huntemann, M., Han, J., Chen, I., Mavromatis, K., Markowitz, V., Ivanova, N., Ovchinnikova, G., Pagani, I., Pati, A., Goodwin, L., Woyke, T., Kyrpides, N., (2013), Genome sequence of the South American clover-nodulating Rhizobium leguminosarum bv. trifolii strain WSM597, Standards in Genomic Sciences, 9, 2, pages 264 - 272. Reeve, W., Melino, V., Ardley, J., Tian, T., De Meyer, S., Terpolilli, J., Tiwari, R., Yates, R., O'Hara, G., Howieson, J., Ninawi, M., Held, B., Bruce, D., Detter, C., Tapia, R., Han, C., Wei, C., Huntemann, M., Han, J., Chen, I., Mavromatis, K., Markowitz, V., Szeto, E., Ivanova, N., Mikhailova, N., Pagani, I., Pati, A., Goodwin, L., Woyke, T., Kyrpides, N., (2013), Genome sequence of the Trifolium rueppellianum -nodulating Rhizobium leguminosarum bv. trifolii strain WSM2012, Standards in Genomic Sciences, 9, 2, pages 283 - 293. Reeve, W., De Meyer, S., Terpolilli, J., Melino, V., Ardley, J., Tian, T., Tiwari, R., Howieson, J., Yates, R., O'Hara, G., Ninawi, M., Lu, M., Bruce, D., Detter, C., Tapia, R., Han, C., Wei, C., Huntemann, M., Han, J., Chen, I., Mavromatis, K., Markowitz, V., Ivanova, N., Pagani, I., Pati, A., Goodwin, L., Woyke, T., Kyrpides, N., (2013), Genome sequence of the Ornithopus/Lupinus-nodulating Bradyrhizobium sp. strain WSM471, Standards in Genomic Sciences, 9, , pages 254 - 263. Reeve, W., Tian, T., De Meyer, S., Melino, V., Terpolilli, J., Ardley, J., Tiwari, R., Howieson, J., Yates, R., O'Hara, G., Ninawi, M., Teshima, H., Bruce, D., Detter, C., Tapia, R., Han, C., Wei, C., Huntemann, M., Han, J., Chen, I., Mavromatis, K., Markowitz, V., Ivanova, N., Ovchinnikova, G., Pagani, I., Pati, A., Goodwin, L., Pitluck, S., Woyke, T., Kyrpides, N., (2013), Genome sequence of the clover-nodulating Rhizobium leguminosarum bv. trifolii strain TA1, Standards in Genomic Sciences, 9, , pages 243 - 253. Terpolilli, J., Garau, G., Hill, Y., Tian, T., Howieson, J., Brau, L., Goodwin, L., Han, J., Liolios, K., Huntemann, M., Pati, A., Woyke, T., Mavromatis, K., Markowitz, V., Ivanova, N., Kyrpides, N., Reeve, W., (2013), Genome sequence of Ensifer medicae strain WSM1369; an effective microsymbiont of the annual legume Medicago sphaerocarpos, Standards in Genomic Sciences, 9, 2, pages 420 - 430. Terpolilli, J., Hill, Y., Tian, T., Howieson, J., Brau, L., Goodwin, L., Han, J., Liolios, K., Huntemann, M., Pati, A., Woyke, T., Mavromatis, K., Markowitz, V., Ivanova, N., Kyrpides, N., Reeve, W., (2013), Genome sequence of Ensifer meliloti strain WSM1022; a highly effective microsymbiont of the model legume Medicago truncatula A17, Standards in Genomic Sciences, 9, 2, pages 315 - 324. Reeve, W., De Meyer, S., Terpolilli, J., Melino, V., Ardley, J., Tian, T., Tiwari, R., Howieson, J., Yates, R., O'Hara, G., Lu, M., Bruce, D., Detter, C., Tapia, R., Han, C., Wei, C., Huntemann, M., Han, J., Chen, I., Mavromatis, K., Markowitz, V., Szeto, E., Ivanova, N., Mikhailova, N., Ovchinnikova, G., Pagani, I., Pati, A., Goodwin, L., Peters, L., Pitluck, S., Woyke, T., Kyrpides, N., (2013), Genome sequence of the Lebeckia ambigua-nodulating Burkholderia sprentiae strain WSM5005T, Standards in Genomic Sciences, 9, 2, pages 385 - 394. Reeve, W., Terpolilli, J., Melino, V., Ardley, J., Tian, T., De Meyer, S., Tiwari, R., Yates, R., O'Hara, G., Howieson, J., Ninawi, M., Teshima, H., Bruce, D., Detter, C., Tapia, R., Han, C., Wei, C., Huntemann, M., Han, J., Chen, I., Mavrommatis, K., Markowitz, V., Ivanova, N., Ovchinnikova, G., Pagani, I., Pati, A., Goodwin, L., Peters, L., Woyke, T., Kyrpides, N., (2013), Genome sequence of the lupin-nodulating Bradyrhizobium sp. strain WSM1417, Standards in Genomic Sciences, 9, 2, pages 273 - 282. Terpolilli, J. J., Hood, G. A. & Poole, P. S. (2012). What determines the efficiency of N2-fixing Rhizobium-Legume symbioses? Advances in Microbial Physiology 60, 325-389. Mulley, G., Lopez-Gomez, M., Zhang, Y., Terpolilli, J., Prell, J., Finan, T. & Poole, P. (2010). Pyruvate is synthesized by two pathways in pea bacteroids with different efficiencies for nitrogen fixation. Journal of Bacteriology 192, 4944-4953. Terpolilli, J. J., O’Hara, G. W., Tiwari, R. P., Dilworth, M. J. & Howieson, J. G. (2008). The model legume Medicago truncatula A17 is poorly matched for N2-fixation with the sequenced microsymbiont Sinorhizobium meliloti 1021. New Phytologist. 179: 62-66. Terpolilli, J. J., O’Hara, G. W., Tiwari, R. P., Dilworth, M. J. & Howieson, J. G. (2008) Investigating N2 fixation in the Medicago-Sinorhizobium symbiosis. In Dakora, F., Chimphango, S., Valentine, A., Elmerich, C., Newton, W. Proceedings of the 15th International N2 fixation Congress. Springer, Netherlands. Pp 145-146. Moeller, A., Horak, F., Lane, C., Knight, D., Kicic, A., Brennan, S., Franklin, P., Terpolilli, J., Wildhaber, J. Stick, S. (2006) Inducible NO synthase is low in airway epithelium from young children with cystic fibrosis. Thorax. 61: 514-520.