Stumbles, Phil - Murdoch University - School of Veterinary and Life Sciences，Molecular and Biomedical Sciences

研究领域

My research areas focus on the regulation of the immune system in health and disease, especially in allergic and inflammatory diseases of the lungs. Research areas include: The role of dendritic cells in controlling immune responses to inhaled allergens The interactions between lung dendritic cells and regulatory cells of the immune system The impact of respiratory viral infections on regulation of the respiratory immune system Interactions between cells of the immune and nervous systems in inflammatory disorders of the lungs and skin

近期论文

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Capozzalo, M., Kim, J., Htoo, J., de Lange, C., Mullan, B., Hansen, C., Resink, J., Stumbles, P., Hampson, D., Pluske, J., (2015), Archives of Animal Nutrition, Archives of Animal Nutrition, 69, 1, pages 17 - 29. Capozzalo, M., Kim, J., Htoo, J., de Lange, C., Mullan, B., Hansen, C., Resink, J., Stumbles, P., Hampson, D., Pluske, J., (2015), Effect of increasing dietary tryptophan to lysine on plasma levels of tryptophan, kynurenine and urea on production traits in weaner pigs experimentally infected with an enterotoxigenic strain of Escherichia coli., Archives of Animal Nutrition, 69, 1, pages 17 - 29. Strickland, D., Fear, V., Shenton, S., Wikstrom, M., Zosky, G., Larcombe, A., Holt, P., Berry, C., von Garnier, C., Stumbles, P., (2014), Persistent and Compartmentalised Disruption of Dendritic Cell Subpopulations in the Lung following Influenza A Virus Infection, PLoS One, 9, 11, pages -. Rinaldi, C., Penhale, W., Stumbles, P., Tay, G., Berry, C., (2014), Modulation of Innate Immune Responses by Influenza- Specific Ovine Polyclonal Antibodies Used for Prophylaxis, PLoS One, 9, 2, pages e89674 -. Seydoux, E., Rothen-Rutishauser, B., Nita, I., Balog, S., Gazdhar, A., Stumbles, P., Petri-Fink, A., Blank, F., von Garnier, C., (2014), Size-dependent accumulation of particles in lysosomes modulates dendritic cell function through impaired antigen-processing, International Journal of Nanomedicine (Online), 9, , pages 3885 - 3902. Blank, F., Stumbles, P., Seydoux, E., Rothen, B., Holt, P., Strickland, D., von Garnier, C., (2013), Size-Dependent Uptake of Particles by Pulmonary Antigen-Presenting Cell Populations and Trafficking to Regional Lymph Nodes, American Journal of Respiratory Cell and Molecular Biology (Print), 49, 1, pages 67 - 77. Prakash, N., Stumbles, P., Mansfield, C., (2013), Initial Validation of Cytokine Measurement by ELISA in Canine Feces, Open Journal of Veterinary Medicine, 3, , pages 282 - 288. Tenaya, I., Heel, K., Stumbles, P., Wilcox, G., (2012), Flow cytometric analysis of lymphocyte subset kinetics in Bali cattle experimentally infected with Jembrana disease virus, Veterinary Immunology and Immunopathology, 149, 3-4, pages 167 - 176. Capozzalo, M., Kim, J., Htoo, J., de Lange, C., Mullan, B., Hansen, C., Stumbles, P., Hampson, D., Pluske, J., (2012), An increased ratio of dietary tryptophan to lysine improves feed efficiency and elevates plasma tryptophan and kynurenine in the absence of antimicrobials and regardless of infection with enterotoxigenic Escherichia coli in weaned pigs., Journal of Animal Science: leading source of new knowledge and perspectives in animal science, 90, SUPPL4, pages 191 - 193. Blank, F., Stumbles, P., von Garnier, C., (2011), Opportunities and challenges of the pulmonary route for vaccination, Expert Opinion on Drug Delivery, 8, 5, pages 547 - 563. Fear, V., Burchell, J., Lai, S., Wikstrom, M., Blank, F., von Garnier, C., Turner, D., Sly, P., Holt, P., Strickland, D., Stumbles, P., (2011), Restricted aeroallergen access to airway mucosal dendritic cells in vivo limits allergen-specific CD4+ T cell proliferation during the induction of inhalation tolerance, Journal of Immunology, 187, 9, pages 4561 - 4570. Stumbles, P., Strickland, D., Wikstrom, M., Thomas, J., von Garnier, C., Holt, P., (2010), Identification and isolation of rodent respiratory tract dendritic cells., Methods in Molecular Biology, 595, , pages 249 - 263. Burchell, J., Strickland, D., Stumbles, P., (2010), The role of dendritic cells and regulatory T cells in the regulation of allergic asthma, Pharmacology & Therapeutics, 125, 1, pages 1 - 10. Wikstrom, M., Batanero, E., Judd, S., Wiqvist, K., Holt, P., Stumbles, P., (2010), Lung homing T-cell generation is dependent on strength and timing of antigen delivery to lymph nodes, Immunology and Cell Biology, 88, 6, pages 658 - 666. Burchell, J., Wikstrom, M., Stumbles, P., Sly, P., Turner, D., (2009), Attenuation of allergen-induced Airway Hyperresponsiveness is mediated by airway regulatory T cells, American Journal of Physiology: Lung Cellular and Molecular Physiology (Print), 296, 3, pages L307 - L319. Zosky, G., Larcombe, A., White, O., Burchell, J., von Garnier, C., Holt, P., Turner, D., Wikstrom, M., Sly, P., Stumbles, P., (2009), Airway hyperresponsiveness is associated with activated CD4+ T cells in the airways, American Journal of Physiology: Lung Cellular and Molecular Physiology (Print), 297, 2, pages L373 - L379. von Garnier, C., Wikstrom, M., Zosky, G., Turner, D., Sly, P., Smith, M., Thomas, J., Judd, S., Strickland, D., Holt, P., Stumbles, P., (2008), Enhanced allergen-specific uptake and processing by dendritic cells and other antigen-presenting cells precedes the development of allergic airways disease, Swiss Medical Weekly, 138, , pages 19S - 19S. von Garnier, C., Wikstrom, M., Zosky, G., Turner, D., Sly, P., Smith, M., Thomas, J., Judd, S., Strickland, D., Holt, P., Stumbles, P., (2007), Allergic airways disease develops after an increase in allergen capture and processing in the airway mucosa, Journal of Immunology, 179, , pages 5748 - 5759. Wikstrom, M., Stumbles, P., (2007), Mouse respiratory tract dendritic cell subsets and the immunological fate of inhaled antigens., Immunology and Cell Biology, 85, 3, pages 182 - 188. Berry, C., Abdad, M., Mansfield, J., Jacobsen, H., Rezazedeh Vind, A., Stumbles, P., Bartlett, E., (2007), Differential activities of alpha/beta IFN subtypes against influenza virus in vivo and enhancement of specific immune responses in DNA vaccinated mice expressing haemagglutinin and nucleoprotein, Vaccine, 25, 10, pages 1856 - 1867.