Maker, Garth - Murdoch University - School of Veterinary and Life Sciences，Molecular and Biomedical Sciences

研究领域

My research focuses on the application of metabolomics and mass spectrometry to the study of biochemistry. Using these advanced techniques, we can study hundreds of metabolites and entire biochemical pathways in a single analysis. Applied to biomedical science, we can look for biomarkers which will allow us to detect disease earlier; we can study how the body changes as a disease progresses; and we can identify new targets for treating disease. For example, we are currently leading projects to characterise markers of damage from the use of illicit drugs; following the progression of polycystic kidney disease to understand how it could be treated; and identifying new therapies that could be used to limit the brain damage caused by a stroke. We can also apply these techniques to other areas of science, including conservation biology. We are currently involved in studies as diverse as understanding the response of frogs to infection by fungi, and trying to predict the success of captive breeding of numbats. I also have substantial expertise in the analysis of other small molecules, such as pharmaceuticals and other drugs. Through the application of the latest mass spectrometry techniques, I can develop quick and efficient methods for pre-clinical and clinical studies.

近期论文

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Lopresti, A., Maes, M., Meddens, M., Maker, G., Arnoldussen, E., Drummond, P., (2015), Curcumin and major depression: A randomised, double-blind, placebo-controlled trial investigating the potential of peripheral biomarkers to predict treatment response and antidepressant mechanisms of change, European Neuropsychopharmacology, 25, 1, pages 38 - 50. Hyndman, T., Musk, G., Murdoch, F., Maker, G., Whittem, T., (2015), The bioavailability of medetomidine in eight sheep following oesophageal administration, Research in Veterinary Science, 103, , pages 137 - 142. Coghlan, M., Maker, G., Crighton, E., Haile, J., Murray, D., White, N., Byard, R., Bellgard, M., Mullaney, I., Trengove, R., Allcock, R., Nash, E., Hoban, C., Jarrett, K., Edwards, R., Musgrave, I., Bunce, M., (2015), Combined DNA, toxicological and heavy metal analyses provides an auditing toolkit to improve pharmacovigilance of traditional Chinese medicine (TCM), Scientific Reports, 5, , pages 17475 -. Wong, H., Maker, G., Trengove, R., O'Handley, R., (2015), Gas Chromatography-Mass Spectrometry-Based Metabolite Profiling of Salmonella enterica Serovar Typhimurium Differentiates between Biofilm and Planktonic Phenotypes, Applied and Environmental Microbiology, 81, 8, pages 2660 - 2666. Abbiss, H., Rawlinson, C., Maker, G., Trengove, R., (2015), Assessment of automated trimethylsilyl derivatization protocols for GC-MS-based untargeted metabolomic analysis of urine, Metabolomics, 11, 6, pages 1908 - 1921. King, G., Damas, J., Cake, M., Berryman, D., Maker, G., (2014), Influence of glucocorticoids, neuregulin-1, and sex on surfactant phospholipid secretion from type II cells, American Journal of Physiology: Lung Cellular and Molecular Physiology (Print), 306, 3, pages 292 - 298. Lopresti, A., Maker, G., Hood, S., Drummond, P., (2014), A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers, Progress in Neuro-Psychopharmacology & Biological Psychiatry, 48, , pages 102 - 111. King, G., Maker, G., Berryman, D., Trengove, R., Cake, M., (2014), Role of neuregulin-1beta in dexamethasone-enhanced surfactant synthesis in fetal type II cells., FEBS letters, 588, 6, pages 975 - 980. Lopresti, A., Maes, M., Maker, G., Hood, S., Drummond, P., (2014), Curcumin for the treatment of major depression: A randomised, double-blind, placebo controlled study, Journal of Affective Disorders, 167, , pages 368 - 375. Ng, J., Ryan, U., Trengove, R., Maker, G., (2013), Metabolomic Profiling of Faecal Extracts fromCryptosporidium parvum Infection in Experimental MouseModels, PLoS One, 8, 10, pages 1 - 7. Maker, G., Siva, B., Batty, K., Trengove, R., Ferrari, P., Olynyk, J., (2013), Pharmacokinetics and safety of deferasirox in subjects with chronic kidney disease undergoing haemodialysis, Nephrology, 18, 3, pages 188 - 193. Murdoch, F., Maker, G., Nitsos, I., Polglase, G., Musk, G., (2013), Intraperitoneal medetomidine: a novel analgesic strategy for postoperative pain management in pregnant sheep, Laboratory Animals: the international journal of laboratory animal science and welfare, 47, 1, pages 66 - 70. De Meyer, S., Cnockaert, M., Ardley, J., Maker, G., Yates, R., Howieson, J., Vandamme, P., (2013), Burkholderia sprentiae sp. nov., isolated from Lebeckia ambigua root nodules, International Journal of Systematic and Evolutionary Microbiology, 63, 11, pages 3950 - 3957. Musk, G., Netto, J., Maker, G., Trengove, R., (2012), Transplacental transfer of medetomidine and ketamine in pregnant ewes, Laboratory Animals: the international journal of laboratory animal science and welfare, 46, 1, pages 46 - 50. Abbiss, H., Maker, G., Gummer, J., Sharman, M., Phillips, J., Boyce, M., Trengove, R., (2012), Development of a non-targeted metabolomics method to investigate a new rat model of autosomal recessive polycystic kidney disease, Nephrology, 17, 2, pages 104 - 110. Ng, J., Ryan, U., Trengove, R., Maker, G., (2012), Development of an untargeted metabolomics method for the analysis of human faecal samples using Cryptosporidium-infected samples, Molecular and Biochemical Parasitology, 185, 2, pages 145 - 150. Netto, J., Musk, G., Maker, G., Trengove, R., (2011), Liquid chromatography tandem mass spectrometry for the simultaneous quantitative analysis of ketamine and medetomidine in ovine plasma, Biomedical Chromatography, 25, 12, pages 1374 - 1380. Wong, H., Townsend, K., Fenwick, S., Maker, G., Trengove, R., O'Handley, R., (2010), Comparative susceptibility of Salmonella Typhimurium biofilms of different ages to disinfectants., Biofouling, 26, 7, pages 859 - 864. Clode, P., Saunders, M., Maker, G., Ludwig, M., Atkins, C., (2009), Uric acid deposits in symbiotic marine algae, Plant, Cell and Environment, 32, 2, pages 170 - 177. Tan, K., Trengove, R., Maker, G., Oliver, R., Solomon, P., (2009), Metabolite profiling identifies the mycotoxin alternariol in the pathogen Stagonospora nodorum, Metabolomics, 5, 3, pages 330 - 335.