研究领域

My principal research area is developmental biochemistry. In particular, I am interested in the factors that contribute to the perinatal development of key biochemical functions of the liver and lung. This requires an understanding of the role of hormones, peptides and growth factors in stimulating the acquisition of biochemical processes such as hepatic gluconeogenesis and lung surfactant synthesis and secretion, all of which are critical for postnatal survival. I also have an interest in birth-related defects in metabolism and mammalian tissue culture.

My research focuses on the role of hormones and growth factors in initiating the development of the lung during the perinatal period. It involves culturing mammalian lung cells and measuring the effect of these agents on the synthesis and secretion of surfactant phospholipids.

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King, G., Maker, G., Berryman, D., Trengove, R., Cake, M., (2014), Role of neuregulin-1beta in dexamethasone-enhanced surfactant synthesis in fetal type II cells., FEBS letters, 588, 6, pages 975 - 980. King, G., Damas, J., Cake, M., Berryman, D., Maker, G., (2014), Influence of glucocorticoids, neuregulin-1, and sex on surfactant phospholipid secretion from type II cells, American Journal of Physiology: Lung Cellular and Molecular Physiology (Print), 306, 3, pages 292 - 298. Paton, K., Cake, M., Potter, I., (2011), Metabolic responses to exhaustive exercise change markedly during the protracted non-trophic spawning migration of the lamprey Geotria Australis, Journal of Comparative Physiology B: biochemical, systemic, and environmental physiology, 181, 6, pages 751 - 763. Damas, J., Cake, M., (2011), An albumin-associated PLA 2-like activity inactivates surfactant phosphatidylcholine secreted from fetal type II pneumocytes, American Journal of Physiology: Lung Cellular and Molecular Physiology (Print), 301, 6, pages L966 - L974. Abo-Hashema, K., Cake, M., Lukas, M., Knudsen, J., (2001), The interaction of acyl-CoA with acyl-CoA binding protein and carnitine palmitoyltransferase I, International Journal of Biochemistry & Cell Biology, 33, , pages 807 - 815. Paton, K., Cake, M., Potter, I., (2001), Muscle glycogen, lactate and glycerol-3-phosphate concentrations of larval and young adult lampreys in response to exercise, Comparative Biochemistry and Physiology. Part B: Biochemistry & Molecular Biology, 129, , pages 759 - 766. Abo-Hashema, K., Cake, M., Power, G., Clarke, D., (1999), Evidence for Triacylglycerol Synthesis in the Lumen of Microsomes via a Lipolysis-Esterification Pathway Involving Carnitine Acyltransferases, Journal of Biological Chemistry, 274, Dec-10, pages 35577 - 35582. Abo-Hashema, K., Cake, M., Lukas, M., Knudsen, J., (1999), Evaluation of the Affinity and Turnover Number of Both Hepatic Mitochondrial and Microsomal Carnitine Acyltransferases: Relevance to Intracellular Partitioning of Acyl-CoAs, Biochemistry, 38, 48, pages 15840 - 15847. Abo-Hashema, K., Cake, M., Potter, I., (1999), Liver Mitochondria, Confirmed as Intact by Complete Suppression of Succinate Uptake and Oxidation, Possess a Carnitine Palmitoyltransferase 1 That Is Totally Inhibited by Malonyl CoA, Biochemical and Biophysical Research Communications, 258, , pages 778 - 783. Cake, M., Power, G., Stonell, L., Potter, I., (1998), Kinetic behaviour of muscle carnitine palmitoyltransferase I in the lamprey Geotria australis, before and after the marine trophic phase, Journal of Experimental Zoology, 281, , pages 6 - 11. Power, G., Cake, M., Newsholme, E., (1997), Influence of diet on the kinetic behavior of hepatic carnitine palmitoyltransferase I toward different acyl CoA esters., Lipids, 32, , pages 31 - 37. Stonell, L., Cake, M., Power, G., Potter, I., (1997), Comparisons between the kinetic behaviour of the muscle carnitine palmitoyltransferase I of a higher and lower vertebrate, Comparative Biochemistry and Physiology. Part B: Biochemistry & Molecular Biology, 118B, , pages 845 - 850.