个人简介
王长林，1981年生，籍贯辽宁大连，博士学位，生命科学与技术学院教授，博士生导师。主要从事内吗啡肽及类似物的阿片生物活性，神经多肽的构效关系研究。主持在研国家自然科学基金面上项目2项，主持国家自然科学基金青年基金，省自然科学基金联合引导项目，国家重点实验室开放课题等，任现职以来以第一或通讯作者发表SCI论文14篇，总影响因子65，获授权国家发明专利5项。
工作经历
2021/12－至今，哈尔滨工业大学，生命科学与技术学院，教授（博士生导师）
2012/12－2021/12，哈尔滨工业大学，生命科学与技术学院，副教授
2009/7－2012/12，哈尔滨工业大学，生命科学与技术学院，讲师
教育经历
2004/9－2009/6，兰州大学，生命科学学院，硕博连读，理学博士（导师王锐院士）
2000/9－2004/6，兰州大学，生命科学学院，国家生物学基地班，学士
教学成果
获得2015年黑龙江省高等教育学会第二十一次优秀高等教育研究成果一等奖
荣获2020年度哈尔滨工业大学“卓越杯”青年教师教学竞赛理科组优秀奖
近期论文
查看导师最新文章
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Yu-zhe Zhang, Meng-meng Wang, Si-yu Wang, Xiao-fang Wang, Wen-jiao Yang, Ya-nan Zhao, Feng-tong Han, Yao Zhang, Ning Gu*, Chang-lin Wang* Novel cyclic endomorphin analogs with multiple modifications and oligoarginine-vector exhibit potent antinociception with reduced opioid-like side effects. Journal of Medicinal Chemistry, 64: 16801-16819, 2021.
Zhang YZ, Yang WJ, Wang XF, Wang MM, Zhang Y, Gu N*, Wang CL*, The spinal anti-allodynic effects of endomorphin analogs with C-terminal hydrazide modification in neuropathic pain model. Peptides 2020;134:170407.
Wang CL*, Yang DJ, Yuan BY, Wang Y.C-terminal hydrazide modification changes the spinal antinociceptive profiles of endomorphins in mice. Peptides 2018;99:128-133.
Yuan BY, Liu WZ, Wang XF, Zhang YZ, Yang DJ,Wang CL*. Endomorphin-1 analogs with oligoarginine-conjugation at C-terminus produce potent antinociception with reduced opioid tolerance in paw withdrawal test. Peptides 2018;106:96-101.
Liu W, Han F, Qu S, Yao Y, Zhao J, Akhtar ML, Ci Y, Zhang H, Li H, Zhao Y, Yue L, Zhang Y, Wang CL*, Li Y*. MARVELD1 depletion leads to dysfunction of motor and cognition via regulating gliadependent neuronal migration during brain development. Cell Death and Disease 2018;9:999.
Wang CL*, Qiu TT, Yang DJ, Yuan BY, Han FT, Li L, Gu N. Endomorphin-2 analogs with C-terminal esterification produce potent systemic antinociception with reduced tolerance and gastrointestinal side effects. Neuropharmacology 2017;116:98-109.
Wang CL*, Yang DJ, Yuan BY, Qiu TT. Antiallodynic Effects of Endomorphin-1 and Endomorphin-2 in the Spared Nerve Injury Model of Neuropathic Pain in Mice. Anesth. Analg., 2017;125:2123-2133.
Wang CL*, Qiu TT, Diao YX, Zhang Y, Gu N. Novel endomorphin-1 analogs with C-terminal oligoarginine-conjugation display systemic antinociceptive activity with less gastrointestinal side effects. Biochimie 2015 ;116:24-33.
Wang CL*, Xiang Q, Diao YX, Ren YK, Gu N. Differential antinociceptive effects of intrathecal administration of C-terminal esterified endomorphin-2 analogs in mice. Eur. J. Pain 2014;18:1157-1164.
Wang CL*, Diao YX, Xiang Q, Ren YK, Gu N.Diabetes attenuates the inhibitory effects of endomorphin-2, but not endomorphin-1 on gastrointestinal transit in mice Eur. J. Pharmacol.2014;738:1-7.
Wang CL*, Ren YK, Xiang Q, Wang Y, Gu N, Lu C, Wang R*. Characterization of opioid activities of endomorphin analogs with C-terminal amide to hydrazide conversion. Neuropeptides 2013;47:297-304.
Wang CL*, Zhou Y, Guo C, Zhang Y, Wang R*. In vivo characterization of intestinal effects of endomorphin-1 and endomorphin-2 in type 1 diabetic mice. Eur. J. Pharmacol. 2013;698:499-504.
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