王广福 - 哈尔滨工业大学

个人简介

王广福，博士，生命中心PI，求学期间从事光镊技术和冷原子光频标的研究，博士后以来主要从事神经环路和突触可塑性的研究。迄今，已在国际著名学术期刊发表论文21篇，图书章节1篇，其中第一作者或通信作者论文8篇、共同第一作者论文4篇。部分成果被Nature Protocols选为封面文章，被Nature Neuroscience、Current Opinion in Neurobiology等期刊作为亮点进行报导，或被Neuron，Epilepsy Currents期刊评论。工作经历 2008.11-2014.12 弗吉尼亚大学（University of Virginia）研究助理（Research Associate） 2014.12-2017.12 弗吉尼亚大学（University of Virginia）研究科学家（Research Scientist） 2017.12至今哈尔滨工业大学研究员教育经历 1999.09-2003.07 北京大学电子学本科 2003.09-2008.07 北京大学无线电物理博士

研究领域

目前实验室的研究集中在内侧内嗅皮层（medial entorhinal cortex，MEC）。MEC作为海马体和新皮层间的接合部分在空间导航、学习和记忆中起到了举足轻重的作用。MEC中含有多种空间细胞，包括网格细胞（grid cells），头向细胞（head direction cells），边界细胞（border cells），和速度细胞（speed cells）。其中，网格细胞具有呈六边形网格排列的多个空间放电野，是最重要的空间细胞。自从最先在大鼠中发现以来,网格细胞也被发现存在于小鼠、蝙蝠、猴子和人类中。网格细胞与海马体中的位置细胞（place cells）一起构成了大脑中的综合定位系统，即一个内部的GPS。而其他空间细胞，尤其是头向细胞和速度细胞，则被认为是向网格细胞提供信息以进行路径整合（path integration）。在过去的十多年中，网格和其他空间细胞的在体记录加深了人们对它们的认识，但是网格状放电野的形成仍是一个未解之谜。要回答这个问题，不仅需要更深入的行为学研究，也需要有对MEC中细胞特性和神经回路的全面了解。因此，本实验室旨在揭示MEC中空间细胞的单细胞和回路基础

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Laminar and dorsoventral organization of layer 1 interneuronal microcircuitry in superficial layers of the medial entorhinal cortex Yuying Shi, Hui Cui, Xiaoyue Li, Ligu Chen, Chen Zhang, Xinran Zhao, Xiaowan Li, Qiming Shao, Qiang Sun, Kaiyue Yan and Guangfu Wang* 2023 期刊名称 Cell Reports 期卷 42: 112782 (22 pages) Structural basis of adhesion GPCR GPR110 activation by stalk peptide and G-proteins coupling Xinyan Zhu, Yu Qian, Xiaowan Li, Zhenmei Xu, Ruixue Xia, Na Wang, Jiale Liang, Han Yin, Anqi Zhang, Changyou Guo, Guangfu Wang and Yuanzheng He* 2022 期刊名称 Nature Communications 期卷 13: 5513 (11 pages) Revaluation of magnetic properties of Magneto Guangfu Wang#, Peng Zhang#, Suresh K. Mendu#, Yali Wang, Yajun Zhang, Xi Kang, Bimal N. Desai* and J. Julius Zhu* 2020 期刊名称 Nature Neuroscience 期卷 23: 1047–1050 Crystal structure of heliorhodopsin 48C12 Yang Lu#, X. Edward Zhou#, Xiang Gao, Na Wang, Ruixue Xia, Zhenmei Xu, Yu Leng, Yuying Shi, Guangfu Wang, Karsten Melcher, H. Eric Xu and Yuanzheng He* 2020 期刊名称 Cell Research 期卷 30: 88-90 A Genetically Encoded Fluorescent Acetylcholine Indicator for in vitro and in vivo Studies Miao Jing#, Peng Zhang#, Guangfu Wang, Jiesi Feng, Lukas Mesik, Jianzhi Zeng, Huoqing Jiang, Shaohua Wang, Jess C Looby, Nick A Guagliardo, Linda W Langma, Ju Lu, Yi Zuo, David A Talmage, ..., Li I Zhang, Minmin Luo, Yan Song, J Julius Zhu* and Yulong Li* 2018 期刊名称 Nature Biotechnology 期卷 36: 726–737 Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains Lei Zhang#, Peng Zhang#, Guangfu Wang#, Huaye Zhang#, Yajun Zhang, Yilin Yu, Mingxu Zhang, Jian Xiao, Piero Crespo, Johannes W. Hell, Li Lin*, Richard L. Huganir, and J. Julius Zhu 2018 期刊名称 Neuron 期卷 98: 783-800 Piconewton-Scale Analysis of Ras-BRaf Signal Transduction with Single-Molecule Force Spectroscopy Chae-Seok Lim, Cheng Wen, Yanghui Sheng, Guangfu Wang, Zhuan Zhou, Shiqiang Wang, Huaye Zhang, Anpei Ye* and J. Julius Zhu* 2017 期刊名称 Small 期卷 13: 1701972 (11 pages) General Anesthesia Causes Epigenetic Histone Modulation of c-Fos and Brain-Derived Neurotrophic Factor, Target Genes Important for Neuronal Development in the Immature Rat Hippocampus Lorenza D. Massara#, Hari P. Osuru#, Azra Oklopcic, Desanka Milanovic, Srdjan M. Joksimovic, Valentina Caputo, Michael R. DiGruccio, Carlo Ori, Guangfu Wang, Slobodan M. Todorovic and Vesna Jevtovic-Todorovic* 2016 期刊名称 Anesthesiology 期卷 124: 1311-1327 CaV3.2 Calcium Channels Control NMDA Receptor-Mediated Transmission: a New Mechanism for Absence Epilepsy; Guangfu Wang, Genrieta Bochorishvili, Yucai Chen, Kathryn A. Salvati, Peng Zhang, Steve J. Dubel, Edward Perez-Reyes, ..., Karl Deisseroth, Alev Erisir, Slobodan M. Todorovic, Jian-Hong Luo, Jaideep Kapur, Mark P. Beenhakker and J. Julius Zhu* 2015 期刊名称 Genes & Development 期卷 29: 1535-1551 An Optogenetics- and Imaging-Assisted Simultaneous Multiple Patch-Clamp Recording System for Decoding Complex Neural Circuits Guangfu Wang#, Daniel R. Wyskiel#, Weiguo Yang, Yiqing Wang, Lana C. Milbern, Txomin Lalanne, Xiaolong Jiang, Ying Shen, Qian-Quan Sun and J. Julius Zhu* 2015 期刊名称 Nature Protocols 期卷 10: 397-412 Canonical Organization of Layer 1 Neuron-Led Cortical Inhibitory and Disinhibitory Interneuronal Circuits Alice J. Lee#,, Guangfu Wang#, Xiaolong Jiang#, Seraphina M. Johnson, Elizabeth T. Hoang, Fabien Lanté, Ruth L. Stornetta, Mark P. Beenhakker, Ying Shen and J. Julius Zhu* 2015 期刊名称 Cerebral Cortex 期卷 25: 2114-2126 Fragile X Proteins FMRP and FXR2P Control Synaptic GluA1 Expression and Neuronal Maturation via Distinct Mechanisms Weixiang Guo, Eric D. Polich, Juan Su, Yu Gao, Devin M. Christopher, Andrea M. Allan, Min Wang, Feifei Wang, Guangfu Wang and Xinyu Zhao* 2015 期刊名称 Cell Reports 期卷 11: 1651-1666 DISC1 Dynamically Regulates Synaptic N-Methyl-D-Aspartate Responses in Excitatory Neurons Guangfu Wang and J. Julius Zhu* 2014 期刊名称 Biological Psychiatry 期卷 75: 348-350 The Organization of Two New Cortical Interneuronal Circuits Xiaolong Jiang#, Guangfu Wang#, Alic e J. Lee, Ruth L. Stornetta and J. Julius Zhu* 2013 期刊名称 Nature Neuroscience 期卷 16: 210-218; Arf6-GEF BRAG1 Regulates JNK-Mediated Synaptic Removal of GluA1-Containing AMPA Receptors: A New Mechanism for Nonsyndromic X-Linked Mental Disorder Kenne th R. Myers#, Guangfu Wang#, Yanghui Sheng, Kathryn K. Conger, Ja mes E. Casanova* and J. Julius Zhu 2012 期刊名称 Journal of Neuroscience 期卷 32: 11716-11726 Dipole polarizabilities and magic wavelengths for a Sr and Yb atomic optical lattice clock Kai Guo, Guangfu Wang and Anpei Ye* 2010 期刊名称 Journal of Physics B 期卷 43: 135004 (7 pages) Dipole polarizabilities of ns2 1S0 and nsnp 3P0 states and relevant magic wavelengths of group-IIB atoms Anpei Ye and Guagnfu Wang* 2008 期刊名称 Physical Review A 期卷 78: 014502 (4 pages) Calibration of optical tweezers based on acousto-optic deflector and FPGA Qingbao Song, Cheng Wen, Yong Zhang, Guangfu Wang and Anpei Ye* 2008 期刊名称 Chinese Optics Letters 期卷 6: 600-602 Possibility of using Zn as the quantum absorber for a laser-cooled neutral atomic optical frequency standard Guangfu Wang and Anpei Ye* 2007 期刊名称 Physical Review A 期卷 76: 043409 (12 pages) Multi-configuration Dirac-Fock calculations of the hyperfine structure constants A and B of neutral Cu, Ag and Au Shuqiang Song, Guangfu Wang, Anpei Ye, and Gang Jiang* 2007 期刊名称 Journal of Physics B 期卷 40: 475-484 Dynamic holographic optical tweezers using twisted-nematic liquid crystal display Guangfu Wang, Cheng Wen and Anpei Ye* 2006 期刊名称 Journal of Optics A 期卷 8: 703-708