个人简介
Education
Studies in Biology, University of Zurich, Switzerland, 1983-1988
M.Sc. in Molecular Biology, University of Zurich, 1987-1988
Ph.D. in Molecular Biology/Neuroscience, University of Zurich, 1989-1992
Positions and academic appointments
Postdoc - Institute of Molecular Life Sciences (formerly Molecular Biology), University of Zurich, Switzerland, 1992-1993
Postdoctoral Fellow - Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, 1993-1996
Assistant Professor (START Fellow) - Institute of Molecular Life Sciences, University of Zurich, Switzerland, 1996-2006
Associate Professor - Department of Anatomy and Neurobiology, University of Kentucky, Lexington, 2006-2013
Professor - School of Life Sciences and Technology, Harbin Institute of Technology, Harbin, China, since October 2013
研究领域
Molecular genetics and cellular mechanisms of neurodegeneration in Parkinson’s disease and related neurodegenerative disorders
Development of cell-based assays to screen small molecules, drugs and natural compounds with the potential to block neuronal loss
Importance of PINK1-regulated mitochondrial quality control and mitochondrial dynamics in neurodegeneration, neurogenesis and tumorigenesis
Viral gene transfer (AAV, retroviruses, lentiviruses) and CRISPR/Cas9 gene editing for direct in vivo modeling and gene therapy of neurodegenerative disorders (Parkinson’s, Huntington’s, amyotrophic lateral sclerosis)
近期论文
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S. K. Agnihotri, L. Sun, B. K. Yee, R. Shen, R. S. Akundi, L. Zhi, M. J. Duncan, W. A. Cass, H. Bueler. PINK1 deficiency is associated with increased deficits of adult hippocampal neurogenesis and lowers the threshold for stress-induced depression in mice. Behavioural Brain Research 363 (2019), 161-172.
Free download before April 1, 2019 at the following link: https://authors.elsevier.com/a/1YY7X_3oCGviM1
L. Sun, R. Shen, S.K. Agnihotri, Y. Chen, Z. Huang, H. Bueler. Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death, Scientific reports 8(1) (2018) 383.
S.K. Agnihotri, R. Shen, J. Li, X. Gao, H. Bueler. Loss of PINK1 leads to metabolic deficits in adult neural stem cells and impedes differentiation of newborn neurons in the mouse hippocampus, FASEB journal 31(7) (2017) 2839-2853.
J.C. Triplett, Z. Zhang, R. Sultana, J. Cai, J.B. Klein, H. Bueler, D.A. Butterfield. Quantitative expression proteomics and phosphoproteomics profile of brain from PINK1 knockout mice: insights into mechanisms of familial Parkinson's disease, Journal of neurochemistry 133(5) (2015) 750-65.
G.I. Ellis, L. Zhi, R. Akundi, H. Bueler, F. Marti. Mitochondrial and cytosolic roles of PINK1 shape induced regulatory T-cell development and function, European journal of immunology 43(12) (2013) 3355-60.
R. Wang, J.J. Li, S. Diao, Y.D. Kwak, L. Liu, L. Zhi, H. Bueler, N.R. Bhat, R.W. Williams, E.A. Park, F.F. Liao. Metabolic stress modulates Alzheimer's beta-secretase gene transcription via SIRT1-PPARgamma-PGC-1 in neurons, Cell metabolism 17(5) (2013) 685-94.
R.S. Akundi, L. Zhi, P.G. Sullivan, H. Bueler. Shared and cell type-specific mitochondrial defects and metabolic adaptations in primary cells from PINK1-deficient mice, Neuro-degenerative diseases 12(3) (2013) 136-49.
R.S. Akundi, L. Zhi, H. Bueler. PINK1 enhances insulin-like growth factor-1-dependent Akt signaling and protection against apoptosis, Neurobiology of disease 45(1) (2012) 469-78.
R.S. Akundi, Z. Huang, J. Eason, J.D. Pandya, L. Zhi, W.A. Cass, P.G. Sullivan, H. Bueler. Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice, PloS one 6(1) (2011) e16038.
N. Saini, S. Oelhafen, H. Hua, O. Georgiev, W. Schaffner, H. Bueler. Extended lifespan of Drosophila parkin mutants through sequestration of redox-active metals and enhancement of anti-oxidative pathways, Neurobiology of disease 40(1) (2010) 82-92.
H. Bueler. Impaired mitochondrial dynamics and function in the pathogenesis of Parkinson's disease, Experimental neurology 218(2) (2009) 235-46.
J.C. Paterna, A. Leng, E. Weber, J. Feldon, H. Bueler. DJ-1 and Parkin modulate dopamine-dependent behavior and inhibit MPTP-induced nigral dopamine neuron loss in mice, Molecular therapy 15(4) (2007) 698-704.
Z. Dong, D.P. Wolfer, H.P. Lipp, H. Bueler. Hsp70 gene transfer by adeno-associated virus inhibits MPTP-induced nigrostriatal degeneration in the mouse model of Parkinson disease, Molecular therapy 11(1) (2005) 80-8.
J.C. Paterna, J. Feldon, H. Bueler. Transduction profiles of recombinant adeno-associated virus vectors derived from serotypes 2 and 5 in the nigrostriatal system of rats, Journal of virology 78(13) (2004) 6808-17.
Z. Dong, B. Ferger, J.C. Paterna, D. Vogel, S. Furler, M. Osinde, J. Feldon, H. Bueler. Dopamine-dependent neurodegeneration in rats induced by viral vector-mediated overexpression of the parkin target protein, CDCrel-1, Proceedings of the National Academy of Sciences of the United States of America 100(21) (2003) 12438-43.
K. Pajusola, M. Gruchala, H. Joch, T.F. Luscher, S. Yla-Herttuala, H. Bueler. Cell-type-specific characteristics modulate the transduction efficiency of adeno-associated virus type 2 and restrain infection of endothelial cells, Journal of virology 76(22) (2002) 11530-40.
S. Furler, J.C. Paterna, M. Weibel, H. Bueler. Recombinant AAV vectors containing the foot and mouth disease virus 2A sequence confer efficient bicistronic gene expression in cultured cells and rat substantia nigra neurons, Gene therapy 8(11) (2001) 864-73.
J.C. Paterna, T. Moccetti, A. Mura, J. Feldon, H. Bueler. Influence of promoter and WHV post-transcriptional regulatory element on AAV-mediated transgene expression in the rat brain, Gene therapy 7(15) (2000) 1304-11.
C.Klein, H. Bueler, R.C. Mulligan. Comparative analysis of genetically modified dendritic cells and tumor cells as therapeutic cancer vaccines, The Journal of experimental medicine 191(10) (2000) 1699-708.
M. Azzouz, A. Hottinger, J.C. Paterna, A.D. Zurn, P. Aebischer, H. Bueler. Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding Bcl-2, Human molecular genetics 9(5) (2000) 803-11.
M. Glatzel, E. Flechsig, B. Navarro, M.A. Klein, J.C. Paterna, H. Bueler, A. Aguzzi. Adenoviral and adeno-associated viral transfer of genes to the peripheral nervous system, Proceedings of the National Academy of Sciences of the United States of America 97(1) (2000) 442-7.
H. Bueler, A. Aguzzi, A. Sailer, R.A. Greiner, P. Autenried, M. Aguet, C. Weissmann. Mice devoid of PrP are resistant to scrapie, Cell 73(7) (1993) 1339-47.
H. Bueler, M. Fischer, Y. Lang, H. Bluethmann, H.P. Lipp, S.J. DeArmond, S.B. Prusiner, M. Aguet, C. Weissmann. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein, Nature 356(6370) (1992) 577-82.
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