杨帆 - 哈尔滨工业大学 - 生命科学与技术学院

个人简介

杨帆博士于2009年毕业于北京大学化学与分子工程学院物理化学专业，之后在美国西雅图华盛顿大学化学系做博士后，研究助理，代理讲师，2017年底加入哈尔滨工业大学生命科学与技术学院。在北京大学期间，师从北京大学核磁中心金长文教授，运用核磁共振（NMR）的方法研究细菌中重要蛋白质的结构和功能，之后在华盛顿大学与Gabriele Varani 教授合作，将研究领域扩展到RNA与蛋白质/小肽的相互作用，主要包括miRNA，mRNA前体，HIV-TAR，以及paRNA等。杨帆博士在哈尔滨工业大学的实验室将继续开展对重要RNA与蛋白质相互作用的研究，真诚欢迎对生物大分子结构或NMR有兴趣的同学加入！工作经历 2017.12 - 今哈尔滨工业大学副研究员 2015.10 - 2017.6 华盛顿大学（University of Washington）化学学院代理讲师 2013.10 - 2015.10 华盛顿大学（University of Washington）化学学院研究助理 2009.11 - 2013.10 华盛顿大学（University of Washington）化学学院博士后教育经历 2004.9 - 2009.7 北京大学物理化学理学博士 2000.9 - 2004.7 南开大学化学理学学士

研究领域

液体核磁共振研究生物大分子相互作用的分子机制研究内容 1. 不同RNA结合蛋白对microRNA生成过程调控的结构基础 2. RRM和zinc finger等RNA结合结构域的理性设计 3. mRNA前体3’末端加工过程相关蛋白因子与PAS RNA的相互作用关系

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Two distinct binding modes provide the RNA-binding protein RbFox with extraordinary specificity Xuan Ye#, Wen Yang#, Soon Yi, Yanan Zhao, Gabriele Varani*, Eckhard Jankowsky*, Fan Yang* 发表时间 2023 期刊名称 Nature Communications 期卷 14:701 A redox switch regulates the assembly and anti-CRISPR activity of AcrIIC1 Yanan Zhao#, Jiaojiao Hu#, Shan-Shan Yang#, Jing Zhong, Jianping Liu, Shuo Wang, Yuzhuo Jiao, Fang Jiang, Ruiyang Zhai, Bingnan Ren, Hua Cong, Yuwei Zhu, Fengtong Han, Jixian Zhang, Yue Xu, Zhiwei Huang, Shengnan Zhang, Fan Yang* 发表时间 2022 期刊名称 Nature Communications 期卷 13:7071 lncRNA HITT inhibits metastasis by attenuating Rab5-mediated endocytosis in lung adenocarcinoma 作者 Xingwen Wang#, Shanliang Zheng#, Fan Yang, Wenxin Zhang, Dong Zhao, Xuting Xue, Qingyu Lin, Yunfei He, Guohong Hu, Ying Hu* 发表时间 2022 期刊名称 Molecular Therapy 期卷 30(3):1071-1088 Fan Yang, Peter Hsu, Susan Lee, Wen Yang, Derick Hoskinson, Weihao Xu, Claire Moore, Gabriele Varani*. The C-terminus of Pcf11 forms a novel zinc-finger structure that plays an essential role in mRNA 3’-end processing. RNA 23 (1), 98-107, 2017. Yu Chen?, Lorena Zubovic?, Fan Yang?, Katherine Godin, Tom Pavelitz, Javier Castellanos, Paolo Macchi*, Gabriele Varani*. Rbfox proteins regulate microRNA biogenesis by sequence specific binding to their precursors and target downstream Dicer. Nucleic Acids Research 44 (9), 4381-4395, 2016.? co-first authors. Yu Chen, Fan Yang, Lorena Zubovic, Tom Pavelitz, Wen Yang, Katherine Godin, Suxin Zheng, Paolo Macchi, Gabriele Varani*. Targeted inhibition of oncogenic miR-21 maturation with designed RNA-binding proteins. Nature Chemical Biology 12 (9), 717-723, 2016. Wen Yang?, Peter L. Hsu?, Fan Yang, Jae-Eun Song, Gabriele Varani*. Reconstitution of the CstF complex unveils a regulatory role for CstF-50 in its recognition of 3’-end processing signals. Nucleic Acids Research 46 (2), 493-503, 2018.*NAR Breakthrough Article Maria L. Romero Romero, Fan Yang, Yu-Ru Lin, Agnes Toth-Petroczy, Igor N. Berezovsky, Alexander Goncearenco, Wen Yang, Alon Wellner, Fanindra Kumar-Deshmukh, Michal Sharon, David Baker, Gabriele Varani, and Dan S. Tawfik*. Simple yet functional phosphate-loop proteins. Proceedings of the National Academy of Sciences 115 (51), E11943-E11950, 2018. Corey M Nemec, Fan Yang, Joshua M. Gilmore, Corinna Hintermair, Yi-Hsuan Ho, Sandra C. Tseng, Martin Heidemann, Ying Zhang, Laurence Florens, Audrey P. Gasch, Dirk Eick, Michael P. Washburn, Gabriele Varani, and Aseem Z. Ansaria*. Different phospho-isoforms of RNA polymerase II engage the Rtt103 termination factor in a structurally analogous manner. Proceedings of the National Academy of Sciences 114 (20), E3944-E3953, 2017. Ravi P. Barnwal, Fan Yang, and Gabriele Varani*. Applications of NMR to structure determination of RNAs large and small. Archives of Biochemistry and Biophysics 628, 42-56, 2017. Anna Bochicchio, Miroslav Krepl*, Fan Yang, Gabriele Varani, Jiri Sponer, Paolo Carloni*. Molecular basis for the increased affinity of an RNA recognition motif with re-engineered specificity: A molecular dynamics and enhanced sampling simulations study. PLOS Computational Biology 14 (12), e1006642, 2018.