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Xinyu Ma*, Yuwei Zhu*, De Dong*, Yan Chen*, Shubo Wang, Dehui Yang, Zhuo Ma, Anqi Zhang, Fan Zhang, Changyou Guo and Zhiwei Huang# (2022). Cryo-EM structures of two human B cell receptor isotypes. Science. 377, 880-885. (This paper is featured with Perspective, Science. 377, 819-820 (2022))
Yan Chen*, Yuwei Zhu*, Xiang Li*, Wenbo Gao*, Ziqi Zhen, De Dong, Buliao Huang, Zhuo Ma, Anqi Zhang, Xiaocui Song, Yan Ma, Changyou Guo, Fan Zhang, Zhiwei Huang# (2022). Cholesterol inhibits TCR signaling by directly restricting TCR-CD3 core tunnel motility. Molecular Cell. 7;82(7):1278-1287.
Fengxia Zhou*, Rui Gan*, Fan Zhang*, Chunyan Ren, Ling Yu and Zhiwei Huang#(2022) PHISDetector: A tool to detect diverse in silico phage-host interaction signals for virome studies. Genomics, Proteomics & Bioinformatics. doi: 10.1016/j.gpb.2022.02.003
Fan Zhang and Zhiwei Huang#(2021) CRISPR and anti-CRISPR: from mechanism to CRISPR toolboxes discovery. Trends in Biochemical Sciences.
Hongnan Liu*, Yuwei Zhu*, Zebin Lu, Zhiwei Huang# (2021). Structural basis of Staphylococcus aureus Cas9 inhibition by AcrIIA14. Nucleic Acids Res. 21;49(11):6587-6595.
Xianwen Ren*, Wen Wen*, Xiaoying Fan*, Wenhong Hou*, Bin Su*, Pengfei Cai*, Jiesheng Li*, Yang Liu*, Fei Tang*, Fan Zhang*, Yu Yang*……Zhiwei Huang#, Jin-Xin Bei#, Lai Wei#, Xiu-Wu Bian#, Xindong Liu#, Tao Cheng#, Xiangpan Li#, Pingsen Zhao#, Fu-Sheng Wang#, Hongyang Wang#, Bing Su#, Zheng Zhang#, Kun Qu#, Xiaoqun Wang#, Jiekai Chen#, Ronghua Jin#, Zemin Zhang# (2021). COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas. Cell. 184(7):1895-1913.
Shengli Ma*#, Fan Zhang*, Fengxia Zhou*, Hui Li*, Wenyu Ge, Rui Gan, Huan Nie, Biao Li, Yindong Wang, Meng Wu, Duo Li, Dongmei Wang, Zheng Wang, and Yuhong You, Zhiwei Huang# (2021). Metagenomic analysis reveals throat microbiota alterations in patients with COVID-19. Signal Transduction Targeted Therapy. 6, 191.
Fan Zhang*, Rui Gan*, Ziqi Zhen*, Xiaoli Hu*, Xiang Li, Fengxia Zhou, Ying Liu, Chuangeng Chen, Shuangyu Xie, Bailing Zhang, Xiaoke Wu, Zhiwei Huang# (2020). Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals. Signal Transduction Targeted Therapy. 5(1):156.
Kaiming Zhang*, Shuo Wang*, Sahnshan Li*, Yuwei Zhu*, Grigore D. Pintilie, Tung-Chung Mou, Michael F. Schmid, Zhiwei Huang# & Wah Chiu# (2020). Inhibition mechanisms of AcrF9, AcrF8, and AcrF6 against type I-F CRISPR-Cas. PNAS. 117(13):7176-7182.
De Dong*, Lvqin Zheng*, Jianquan Lin*, Bailing Zhang, Yuwei Zhu, Ningning Li, Shuangyu Xie, Yuhang Wang, Ning Gao#, Zhiwei Huang# (2019). Structural basis of assembly of the human T cell receptor-CD3 complex. Nature. 573(7775):546-552. (This paper is featured with News & Views, Nature. 573, 502-504 (2019))
Liyong Dong*, Xiaoyu Guan*, Ningning Li*, Fan Zhang, Yuwei Zhu, Kuan Ren, Ling Yu, Fengxia Zhou, Zhifu Han, Ning Gao & Zhiwei Huang# (2019). An anti-CRISPR protein disables type V Cas12a by acetylation. Nature Structural & Molecular Biology. 26(4):308-314. (This paper is featured with News & Views, Nature Structural & Molecular Biology. 26(4):250-251 (2019))
Minghui Guo*, Kaiming Zhang*, Yuwei Zhu, Grigore D. Pintilie, Xiaoyu Guan, Shanshan Li, Michael F. Schmid, Zhuo Ma, Wah Chiu# & Zhiwei Huang# (2019). Coupling of ssRNA Cleavage with DNase Activity in Type III-A CRISPR-Csm Revealed by Cryo-EM and Biochemistry. Cell Research. 29(4):305-312.
Minghui Guo*, Kuan Ren*, Yuwei Zhu*, Ziyun Tang, Yuhang Wang, Bailing Zhang & Zhiwei Huang# (2019). Structural insights into a high fidelity variant of SpCas9. Cell Research. 29,183-192.
Yuwei Zhu, Zhiwei Huang# (2018). Recent advances in structural studies of the CRISPR-Cas-mediated genome editing tools. National Science Review. doi: 10.1093/nsr/nwy150
Fan Zhang#, Shijia Zhao, Chunyan Ren, Yuwei Zhu, Haibin Zhou, Yongkui Lai, Fengxia Zhou, Yuqiang Jia, Kangjie Zheng & Zhiwei Huang# (2018). CRISPRminer is a knowledge base for exploring CRISPR-Cas systems in microbe and phage interactions. Communications Biology. 31;1:180.
De Dong*, Minghui Guo*, Sihan Wang*, Yuwei Zhu, Shuo Wang,Zhi Xiong, Jianzheng Yang, Zengliang Xu and Zhiwei Huang# (2017). Structural basis of CRISPR-SpyCas9 inhibition by an anti-CRISPR protein. Nature. 546(7658):436-439.
Dan Wu*, Xiaoyu Guan*, Yuwei Zhu*, Kuan Ren, Zhiwei Huang# (2017). Structural basis of stringent PAM recognition by CRISPR-C2c1 in complex with sgRNA. Cell Research. 27(5):705-708.
Pu Gao, Hui Yang, Kanagalaghatta R Rajashankar, Zhiwei Huang and Dinshaw J Patel (2016). Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition. Cell Research. 26(8):901-13.
De Dong*, Kuan Ren*, Xiaolin Qiu*, Jianlin Zheng, Minghui Guo, Xiaoyu Guan, Hongnan Liu, Ningning Li, Bailing Zhang, Daijun Yang, Chuang Ma, Shuo Wang, Dan Wu, Yunfeng Ma, Shilong Fan, Jiawei Wang, Ning Gao and Zhiwei Huang# (2016). Crystal structure of CRISPR-Cpf1 in complex with CRISPR RNA (crRNA). Nature. 532(7600):522-6.
Yingying Guo*, Liyong Dong*, Xiaolin Qiu*, Yishu Wang, Bailing Zhang, Hongnan Liu, You Yu, Yi Zang, Maojun Yang and Zhiwei Huang# (2014). Structural basis for hijacking CBF-β and CUL5 E3 ligase complex by HIV-1 Vif. Nature. 505(7482):229-33. (This paper is featured with News & Views, Nature. 505, 167-168, highlighted in Nature Structural & Molecular Biology, 21, 117 (2014))
Jae-Hyuck Shim, Matthew B. Greenblatt, Weiguo Zou, Zhiwei Huang, Marc N. Wein, Nicholas Brady, Dorothy Hu, Jean Charron, Heather R. Brodkin, Gregory A. Petsko, Dennis Zaller, Bo Zhai, Steven Gygi, Laurie H. Glimcher and Dallas C. Jones (2013). Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts. J Clin Invest. 123(9):4010-22.
Zehan Hu, Chuangye Yan, Peiyuan Liu, Zhiwei Huang, Rui Ma, Chenlu Zhang, Ruiyong Wang, Yueteng Zhang, Fabio Martinon, Di Miao, Haiteng Deng, Jiawei Wang, Junbiao Chang, Jijie Chai (2013). Crystal structure of NLRC4 reveals its autoinhibition mechanism. Science. 341(6142):172-5.
Weiguo Zou, Xi Chen, Jae Shim, Zhiwei Huang, Nicholas Brady, Dorothy Hu, Rebecca Drapp, Kirsten Sigrist, Laurie H. Glimcher, Dallas Jones (2011). The E3 ubiquitin ligase Wwp2 regulates craniofacial development through monoubiquitination of Goosecoid. Nature Cell Biology. 13(1):59-65.
Zhiwei Huang*, Sarah E. Sutton*, Adam J. Wallenfang, Robert C. Orchard, Xiaojing Wu, Yingcai Feng, Jijie Chai and Neal M. Alto (2009). Structural insights into host GTPase isoform selection by a family of bacterial GEF mimics. Nature Structural & Molecular Biology. 16(8):853-60. (This publication was selected as cover story, and high-lighted by Nature China）
Zhiwei Huang, Yingcai Feng, Ding Chen, Xiaojing Wu, Xiaojun Wang, Xingguo Xiao, Wenhui Li, Niu Huang, Lichuan Gu, Guangming Zhong and Jijie Chai (2008). Structural basis for activation and inhibition of the secreted chlamydia protease CPAF. Cell Host & Microbe. 4(6):529-42. (This publication was selected as a research “highlight” by Nature China）
Maikke B. Ohlson, Zhiwei Huang, Neal M. Alto, Jack E. Dixon, Jijie Chai and Samuel I. Miller (2008). Structure and Function of Salmonella SifA Indicate that Its Interactions with SKIP, SseJ, and RhoA Family GTPases Induce Endosomal Tubulation. Cell Host & Microbe. 4(5):434-46.
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