个人简介
1980-1985年：佳木斯医学院，医学学士
1987-1990年：哈尔滨医科大学，医学硕士
1994-1997年：哈尔滨医科大学，遗传学博士
1985-1987年：佳木斯医学院，微生物与免疫教研室，助教
1990-1994年：哈尔滨医科大学，生物学教研室，讲师
1997-1999年：哈尔滨医科大学，预防医学博士后流动站，博士后
1999-2004年：哈尔滨医科大学，遗传学研究室，教授
2001-2003年：哈佛大学医学院，分子病理学实验室，访问学者
2004年-至今：哈尔滨工业大学，生命科学与技术学院，教授
近期论文
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Xiaoqing Zhang, Peng Dou, Muhammad Luqman Akhtar, Fei Liu, Xibo Hu, Lijun Yang, Depeng Yang, Xiaohan Zhang, Yiqun Li, Shupei Qiao, Kai Li, Ran Tang, Chao Zhan, Yue Ma , Qixiang Cheng, Yan Bai, Fang Han, Huan Nie*, Yu Li*.NEU4 inhibits motility of HCC cells by cleaving sialic acids on CD44.Oncogene, doi: 10.1038/s41388-021-01955-7. 2021.
Depeng Yang, Lijun Yang, Jialing Cai, XiboHu, Huaxin Li, Xiaoqing Zhang, Xiaohan Zhang, Xinghe Chen, Haiyang Dong, Huan Nie*, Yu Li*. A sweet spot for macrophages: Focusing on polarization. Pharmacol Res. 167:105576. doi: 10.1016/j.phrs.2021.105576. 2021.
Chunbo Wang, Depeng Yang, Xiaoqing Zhang, Xiaohan Zhang, Lijun Yang, Pingping Wang, Wenyang Zhou, Huaxin Li, Yiqun Li, Huan Nie, Yu Li*. Association of PTEN Gene SNPs rs2299939 With PFS in Patients With Small Cell Lung Cancer Treated With Early Radiotherapy.Front Genet. 23; 11:298. doi: 10.3389/fgene.00298. eCollection 2020.
Xiaohan Zhang, Xiuyun Shi, Xin Lu, Yiqun Li, Chao Zhan, Muhammad Luqman Akhtar, Lijun Yang, Yunfan Bai, Jianxiang Zhao, Yu Wang, Yuanfei Yao, Yu Li*, and Huan Nie. Novel Metabolomics Serum Biomarkers for Pancreatic Ductal Adenocarcinoma by the Comparison of Pre-, Postoperative and Normal Samples. J Cancer. 11(16): 4641- 4651, 2020.
Zongjun Liu#, Tuo Li, Fang Han, You Wang,* Yang Gan,* Junhui Shi, Tianran Wang, Muhammad Luqman Akhtar, and Yu Li*.A Cascade-Reaction Enabled Synergistic Cancer Starvation/ROS-mediated /chemotherapy with Enzyme Modified Fe-based MOF. Biomater Sci,7(9): 3683-3692, 2019.
Chunbin Zhang, Fang Han, Ming Shi, Haoxiu Sun, Yiqun Li, Yanpeng Ci, Yuanfei Yao, Peng Dou, Muhammad luqman Akhtar, Huan Nie, Jie He, Li Y*. MARVELD1 interacting with catalase regulates reactive oxygen species metabolism and mediates the sensitivity to chemotherapeutic drugs in epithelial tumors of the reproductive system. Mol Carcinog, 08;58(8):1410-1426, 2019.
Xin Lu, Xiaohan Zhang, Yongjian Zhang, Kun Zhang, Chao Zhan, Xiuyun Shi, Yiqun Li, Jianxiang Zhao, Yunfan Bai, Yu Wang, Huan Nie*, Yu Li*. Metabolic profiling analysis upon acylcarnitines in tissues of hepatocellular carcinoma revealed the inhibited carnitine shuttle system caused by the downregulated carnitine palmitoyltransferase 2. Mol Carcinog, 58(5):749-759. doi: 10.1002/mc.22967.2019.
Yanpeng Ci, Xiaoning Li, Maorong Chen, Jiateng Zhong, Brian J. North, Hiroyuki Inuzuka, Xi He, Yu Li* & Jianping Guo* & Xiangpeng Dai*. SCF E3 ubiquitin ligase targets the tumor suppressor ZNRF3 for ubiquitination and degradation. Protein Cell,9(10):879-889, 2018.
Weizhe Liu, Fang Han, Shuai Qu, Yuanfei Yao, Jianxiang Zhao, Muhammad Luqman Akhtar, Yanpeng Ci, Hao Zhang, Hongfei Li, Yufang Zhao, Lei Yue, Yao Zhang, Changlin Wang*&Yu Li*. MARVELD1 depletion leads to dysfunction of motor and cognition via regulating glia-dependent neuronal migration during brain development. Cell Death & Disease, 9: 999, 2018.
Chen Y, Zhang H, Han F, Yue L, Qiao C, Zhang Y, Dou P, Liu W, Li Y*. The depletion of MARVELD1 leads to murine placenta accreta via integrin β4-dependent trophoblast cell invasion. J Cell Physiol, 233(3): 2257-2269, 2018.
Yao Y, Shi M, Liu S, Li Y, Guo K, Ci Y, Liu W, Li Y*. MARVELD1 modulates cell surface morphology and suppresses epithelial-mesenchymal transition in non-small cell lung cancer. Mol Carcinog.55(11):1714-1727. doi: 10.1002/mc.22421. 2016.
Synergistic Effects of Incubation in Rotating Bioreactors and Cumulative Low Dose 60Co γ-ray Irradiation on Human Immortal Lymphoblastoid Cells. Microgravity Science and Technology: 2012, 24 (5):335-344
Recent advances in sialic acid-focused glycomics. Journal of Proteomics. 2012.5
Identification and characterization of a novel gene, c1orf109, encoding a CK2 substrate that is involved in cancer cell proliferation. Journal of Biomedical Science 2012.5
MARVELD1 inhibited cell proliferation and enhance chemosensitivity via increasing expression of p53 and p16 in hepatocellular carcinoma. Cancer science. 2012.3
Recent Advances in the Synthesis and Biomedical Applications of Chain-End Functionalized Glycopolymers. Journal of Carbohydrate Chemistry. 2012.2
A three-dimensional in vitro culture model for primary neonatal rat ventricular myocytes. Current applied physics. 2012.5
Rotary culture promotes the proliferation of MCF-7 cells encapsulated in three- dimensional collagen-alginate hydrogels via activation of ERK1/2-MAPK pathway. 2012.2
Fabrication of engineered heart tissue grafts from alginate/collagen barium composite microbeads. Biomedical materials. 2011.5
Knockdown of Rab5a expression decrease cancer cell motility and invasion by integrin-mediated pathway. J Biomed Sci. 2011,17;18:58
Identification of mouse MARVELD1 as a candidate microtubule-associated protein that inhibites cell-cycle progression and migration. Molecules and Cells. 2011;31(3)：267-274.
Human Serum N-Glycan Profiles Are Age and Sex Dependent. age aging. 2011;40(5):568-75
Simulated weightlessness leads to structural aberrant spindle apparatus and cell cycle arrest in NIH3T3 fibroblast cells. Space Medicine & Medical Engineering. 2010;23(6)416-418
Identification and characterization of MARVELD1, a novel nuclear protein that is downregulated in multiple cancers and silenced by DNA methylation. Cancer Letters. 2009;282:77-86.
Identification of Interaction between MARVELD1 and Importinβ1. Chin J. Biochem. & Mol. Bio. 2009;25:735-739.
Silencing LRP1B with huge transcript by RNAi method. HEREDITAS. 2009;31:36-42.
The study of damage of rat terminal differentiation PC12 cell under γ-radiation and simulated microgravity. Progress in Modern Biomedicine. 2008;8(12):2204-2207
Cloning of Novel Tumor Metastasis-Related Genes from the Highly Metastatic Human Lung Adenocarcinoma Cell Line Anip973. Journal of Genetics and Genomics. 2007;34: 189-195
Insulin Receptor Activation in Solitary Fibrous Tumors. J. of Pathology. 2007;211:550-554.
Genomic and functional evidence for an ARID1A tumor suppressor role. Genes Chromosomes Cancer. 2007;46:745-750.
UTRN on chromosome 6q24 is mutated in multiple tumors. Oncogene 2007;26: 6220-6228.
学术兼职
中国细胞生物学会常务理事
黑龙江省细胞生物学学会理事长
黑龙江省遗传学会常务理事
黑龙江省生物医学工程学会常务理事
国家自然科学基金委员会评审专家
国家科技部科技进步奖函评专家
美国得克萨斯A&M大学健康医学中心，IBT Adjunct faculty member
遗传杂志编委
航天医学与工程杂志编委
中华医学遗传学杂志编委
国际遗传学杂志编委
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